Risankizumab and Headaches: What Users Say
Brand names: Skyrizi
Reviews for Risankizumab
- Pet...
- Taken for 1 to 6 months
- July 21, 2025
Risankizumab for Psoriasis "Within 2 weeks of the first dose, my psoriasis cleared up nearly 100%, which is incredible. For about 2 weeks after every injection, I get a low-grade headache (not fever). Just a persistent, mildly annoying headache. After my 4th dose, within 4 days I developed severe inflammation around my sciatic nerve. Going on three weeks now of discomfort. I cannot say it is exactly in correlation, but I did nothing to bring it on. I have had issues not nearly as severe in the past few years with sciatica, but NOTHING close to this level of pain and discomfort. All in all, I am extremely happy with the medication's effects on my skin and general quality of life."
- Kri...
- Taken for less than 1 month
- March 10, 2023
For Crohn's Disease "I've had one loading dose and experienced flu-like symptoms (tiredness, headache, body aches, nausea) for 2 days and then moderate to severe knee and back pain with fatigue."
Frequently asked questions
- Who is the actress in the Skyrizi commercial?
- What are IL-23 Inhibitors and how do they work?
- Does Skyrizi cause cancer?
- Who makes Skyrizi and where is it made?
See also:
More about risankizumab
- risankizumab consumer information
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- Reviews (71)
- Side effects
- Dosage information
- During pregnancy
- Drug class: interleukin inhibitors
- Breastfeeding
Risankizumab for Psoriatic Arthritis "I have PsA and psoriasis, HLA-B27+ with elevated monocytes 900+. The 1st week after taking your first dose, you’ll feel like crap since your immune system gets all scrambled, but after that, you will find significant joint improvement and experience less fatigue. Also got a headache, felt mildly nauseous, and had slight constipation. Your intestines have to adjust, almost all PsA patients have some hidden intestinal inflammation as this disease is systemic (impacts the entire body). It feels like a disease flare-up + sinus infection at the same time, lol. The headaches were tension/sinus type. Your joints will hurt more the 1st week. It’s normal, stick with it. I was able to shower and wash my entire body standing up for the first time in 10 years tonight. Usually, I can only wash 50% before my back gets too stiff, my feet begin to burn/throb, and my muscles in my upper body give out due to muscle and systemic fatigue. I’m 36F, btw."