Compazine User Reviews & Ratings (Page 2)
Compazine has an average rating of 2.2 out of 10 from a total of 298 reviews on Drugs.com. 11% of reviewers reported a positive experience, while 85% reported a negative experience.
Reviews for Compazine
- Ang...
- February 14, 2021
For Nausea/Vomiting "I have migraines, vomiting, gallbladder issues. I was asked if I wanted Zofran or Compazine. I asked a little bit about side effects, and the nurse said it's for migraines, vomiting, put in my IV. Fifteen minutes later, like the room got dark, and I couldn't stay still. Thirty minutes later, I called my mom crying, telling her I'm dying, there is no way I'm coming back from the hospital. Many times I was about to rip the IV out, pacing the hospital bed with the IV cord on me. I felt the oncoming sense of doom, somewhat dismembered my IV on my arm. At one point, I was about to rip the IV out, had no ride home an hour away from home. I was going to run out of the room into the streets, zero below. I got a nurse and she said, 'Yeah, the medicine can do that to people, have reactions.' Benadryl, reverse it, it took thirty more minutes for them to bring Benadryl in. About ten minutes, I finally dozed off. But I still couldn't stop moving, walking around and nervous panic. I had gotten released, I had to get Benadryl from the store to keep it reversed for 24 hours. Worst, dangerous drug. I will never take an unknown medication again."
- Fio...
- March 17, 2019
For Nausea/Vomiting "I was prescribed this med in pill form for nausea from my chemotherapy as a backup in case Zofran did not work. Because Zofran caused me constipation, I asked my care team if I could use the Compazine as the first defense. They said go ahead and try it. While taking this med, I didn't want to sleep, didn't want to be awake, couldn't sit, couldn't stand, or wait in line, had to pace back and forth to stop myself from doing something drastic. I snapped at loved ones because I was so desperate. I felt fear, dread, and paranoia. At first, I thought it was the chemotherapy I was on that was causing all these things, but I finally figured out it was the Compazine. You snap out of the horrible side effects about 12 to 24 hours after taking your last dose. It feels like you are breaking a fever and finally feel more relaxed and relieved. I stopped taking it. Hoping this review will be helpful for those on chemo. Sometimes with all the drugs we take, it's hard to pinpoint which one is the culprit."
Frequently asked questions
- Nev...
- Taken for less than 1 month
- November 13, 2016
For Nausea/Vomiting "They gave me this medication via IV in the ER for a very intense migraine and extreme nausea. I would never recommend this medication to anyone, ever. The second it was pushed through, I started having an extreme panic attack, something like I have never felt before, like a huge wave of doom rushed over me. I started freaking out so badly I almost ripped my IV out and ran away. It was so traumatizing to me that they pushed a big dose of Ativan through my IV just to knock me out. I truly thought I was dying... And after all that, it felt like my skin was crawling for a good 32 hours. No, thank you. Never again will I allow this in my body."
- Ikn...
- October 23, 2019
For Anxiety "Everyone on here. I know exactly what you experienced, it's a gruesome condition called akathisia. And the doctors know about it. But they will not tell you! It is a serious side effect. Because people can't stand the way they feel with akathisia. Please join the akathisia group on Facebook. There is help and support if you're still suffering."
Are you taking this medicine?
Your review helps others make informed decisions.- Car...
- May 11, 2013
For Nausea/Vomiting "Compazine is chemically similar to Thorazine, both of which can cause extreme and sometimes dangerous reactions in people who have a risk of serotonin syndrome or sensitivities. I personally experienced rage reactions to Compazine when it was used to treat nausea from migraines."
- AJO...
- Taken for less than 1 month
- December 10, 2019
For Nausea/Vomiting "Y'all, my experience was exactly like so many others. I was having dizzy spells for over a week and then suddenly had the world's worst headache, so I went in. They gave me Toradol and Compazine through an IV, and within ten minutes, I thought I was going insane. I asked to go to the bathroom just to get out of the room. I couldn't sit still and felt so panicked. On my way back from the bathroom, I seriously considered ripping out my IV. When the nurse came in, I stopped my fluids and went home. Had to sign a paper that I was refusing treatment, but I couldn't be in that room any longer."
- Gab...
- July 16, 2017
For Anxiety "Given this medication for a headache 3 weeks ago, still feeling side effects! Very restless, insomnia, irrational thoughts, I feel like I've lost touch with reality! It's horrible! I wish they would've told me before they put it in me through IV! If anyone please knows what to do to fall back into reality, please share."
- Dkb...
- Taken for less than 1 month
- April 27, 2019
For Anxiety "Went to the ER with a headache and was given an IV with Benadryl and Compazine. IMMEDIATELY I began to have a panic attack. The only way I can describe it is like being buried alive. I was so tired but coming out of my skin. Worst feeling of my life and now going to the hospital and regular routine appointments give me anxiety. I’m afraid of getting shots and taking medicines. My life has not been the same since getting that IV. I don’t understand how this drug could be used to treat anxiety."
- Anonymous
- August 27, 2018
For Nausea/Vomiting "I went to the ER with a migraine and nausea/vomiting. I saw the doctor, and then the nurse brought a medication into my room, Compazine. Then they wheeled me over to get a CT scan. That’s when things went all bad. Sitting there in the hallway on the gurney, I began having this overwhelming feeling of anxiety/panic! The problem was my body felt like I couldn’t move, like there was a disconnect from my mind and my body. After the CT scan, I was back in the room. All I could think about was when I could get out of that ED and when those feelings of anxiety would stop! It was literally the worst feeling in the world, so hard to describe, but I have never felt so uncomfortable and anxious, yet unable to do anything about it. I wanted to rip out my IV and run out of there ASAP! It took an entire 3 DAYS before I started to feel “normal” again! It was torture. Worst experience. Never, ever take Compazine if you can avoid it. I now have Compazine listed as an allergy."
- PA...
- Taken for less than 1 month
- May 31, 2014
For Anxiety "This medication gave me the worst experience of my life. It made me sleepy, yes. But at the same time, it sped up my mental discomfort, and it made my muscles jump. Similar to restless leg syndrome, but throughout my entire body. It was so bad they had to reverse it with Benadryl to alleviate the symptoms, and finally they gave me a mixture of Valium and Demerol to put me in a twilight state until it passed. If you have any medication allergies, even mild, I would strongly advise against this medication."
- She...
- Taken for less than 1 month
- April 2, 2019
For Anxiety "This medication gave me the worst thoughts of suicide, fear, and anxiety. My mother had to sleep with me for a week after so I wouldn’t cry due to being alone in my thoughts. This medication should be avoided at all cost. Refuse this medication."
- sky...
- Taken for less than 1 month
- July 16, 2019
For Nausea/Vomiting "I know all drugs come with side effects, but please listen to me and other people on here. I was given Compazine one time in February of 2019 for vomiting. I experienced graphic, really dark thoughts, hallucinations, akathisia, tinnitus, panic attacks, brain zaps, a feeling of bugs crawling under my skin, paranoia, and at one point a complete inability to feel joy. I am still not myself, and it is now July. There is nothing any doctor can do for you once this medication messes you up. I was a normal wife, mother, and employee, and some days now I can’t take care of myself, let alone my family. This drug has ruined my life, and it was one dose for something as simple as nausea. There are much safer alternatives for nausea and vomiting."
- Sco...
- Taken for less than 1 month
- October 26, 2018
For Anxiety "I went in to ER for a migraine and was given this. Immediately, a rash developed on my arm, and I felt like I was going crazy! I felt as if someone was trying to kill me, and I had to get out of that room! I NEVER had anxiety in my life. I didn’t realize that is what caused it until my 2nd ER visit, months later, the same thing happened. Did some research and spoke to my doctor and was told it was the Compazine! It is now listed as an allergy in my chart. I felt like I was full-blown psychotic! Lasted for a couple of days until I felt normal again. This med should be recalled!"
- Red...
- Taken for less than 1 month
- December 26, 2018
For Anxiety "So I was given this in an ER to treat status migrainosus, and it made me go insane. I couldn’t sit still, I wanted to leave. More than wanted, I NEEDED to leave. I couldn’t stand it. I wanted to rip out my IV, but I didn’t. I bit as hard as I could into my arm until I broke the skin, that’s how crazy I went. I had to tell the nurse that it was a 'love bite' so they didn’t lock me up for self-harm. They subsequently gave me some Ativan and Benadryl to calm me down, and that fixed the problem. Well, after a few doses anyway. I will NEVER touch Compazine ever again."
- Kla...
- Taken for less than 1 month
- May 28, 2019
For Nausea/Vomiting "Went to ER for a migraine I could not control. Was given Compazine by IV. Instantly felt like I was crawling out of my skin, couldn't sit still. Went home, and a few hours later ended back at the ER due to uncontrollable body movements. When I got there, the doctor told me it was dystonia, which is a side effect reaction from the medication Compazine, which is irreversible. It has been almost 7 months since this day, and I still have uncontrollable muscle movements and severe anxiety. Please do not take this drug, my life has been hell ever since."
- Lac...
- October 8, 2019
For Nausea/Vomiting "I went into the ER for a really bad migraine and vomiting. They gave me Benadryl and Compazine. Within three minutes, I had the worst panic attack of my life. My anxiety was through the roof. I unhooked myself from everything that I could and tried to get my IV out and demanded that I be let go, thinking I would feel better when I got home. I have not slept in over 24 hours. I'm now on day 2, and I still want to crawl out of my skin. I can't stop shaking and crying. I want to crawl out of my skin or run away to get away from this feeling. I'm also shaky, and anytime I think I'm about to fall asleep, I get weird sadistic images that wake me up right away before I'm even all the way asleep. I don't know why this drug is legal. I hope people read these reviews and please don't let any doctor give you this medication-the worst feeling of my life."
- Rit...
- February 29, 2020
For Nausea/Vomiting "I was given Compazine IV in the ER (which I work at the hospital) for a severe migraine. Not much later after I started getting horrible sensations in my head. And creepy crawly all over. Couldn't communicate. Couldn't walk straight. And no one noticed this! I was too sick to even realize it was the Compazine at the time. I had no idea it is in the Thorazine family! Now I'm marked as having an allergy to Compazine. Nightmare!"
- Kle...
- October 19, 2015
For Nausea/Vomiting "I was prescribed Compazine in 1989 for severe morning sickness during the fourth month of my second pregnancy. By the third day, I was rushed to the hospital because my chin locked over my left shoulder, my tongue hung out of my mouth, impeding my speech, the muscles in my eyes froze, keeping me from blinking. My five-year-old got home from school and found me drooling on myself, grunting because I could not speak. Good thing I'd taught her how to call 911. Shortly, an ambulance drove up and rushed me to the emergency room. They thought I'd had a stroke. Luckily, I had the vial of Compazine in my purse. Needless to say, my son was born with neurological issues, which have lasted a lifetime."
- PBa...
- Taken for 1 to 6 months
- December 13, 2019
"I went to the ER twice for a migraine and received Compazine, Toradol, and Benadryl via IV. Both times I felt like my body was not my own. I instantly felt jittery and couldn’t sit still. I wanted to jump out of my skin. All I wanted was to go home. The cocktail worked, but when I was finally released, I could barely drive home because I couldn’t sit still for more than a few seconds. I had to pull over multiple times. I called the ER when I got home because I couldn’t sleep at all. The nurse told me to take another dose of Benadryl and it should subside. It took 2 days to get back to normal. I thought it was the combination of Compazine, Toradol, and Benadryl that caused this side effect until I was admitted to Johns Hopkins for DHE treatment. They gave me Compazine before the start of the treatment, and I immediately felt crazy. All the symptoms I felt in the ER happened again. The worst medication I have ever received. Count yourself lucky if you didn’t experience this."
- bla...
- Taken for 2 to 5 years
- April 30, 2015
For Nausea/Vomiting "I have been on Compazine for over 2 years, and it has been an absolute overall relief of nausea, anxiety, and nerves/nervous tension. Finding a doctor who will prescribe it without a struggle and/or reservation is a whole other issue. I've been told it carries too many side effects and isn't considered safe or for long-term use. I've been told to switch to Zofran. The upside is Zofran seems to have a fairly good rating. I never suffered side effects from the Compazine."
- JMG...
- March 23, 2017
For Nausea/Vomiting "My wife was administered Compazine after receiving chemo to relieve nausea symptoms. Within 12 hours, she became restless, irritable, felt like her muscles were being ripped out of her body, it caused her to have a 103 fever and diarrhea, coupled with the chemo almost killed her. She ended up in the ICU unconscious and almost died. Our team of doctors told us this was a rare occurrence. From reading the other reviews and witnessing this firsthand, I would advise anyone, if offered this drug, to decline. It was truly the biggest nightmare of my wife's life. On the scale of 1-10 above, this survey asked to select how effective this medicine was. Therefore, we would give it a 0=ZERO."
- cru...
- April 22, 2019
For Anxiety "I was given Compazine in the hospital along with Toradol. I have been to the ER many, many times for migraines, and they wouldn't listen to me. I usually get Toradol and just a tiny bit of morphine. The doctor said no and gave me this combo. That was two years ago, and ever since, I have had to be on multiple medications from the severe side effects I had. I ran out of the hospital, complete panic-stricken, horrible thoughts, dread, doom, you name it. I am now taking several pills a day all because of one single dose of Compazine. I cannot get any lawyers that will handle my case because it's against the drug company. Awful, awful drug."
- Taa...
- March 2, 2019
For Nausea/Vomiting "Went to the ER and was given this drug without any details. Not one time did the nurses tell me what was about to happen. I thought I was going crazy!!! I could not sit still, it was the worst experience ever!!!! Do NOT allow the medical sheep to give this to you. Matter of fact, when you go to the ER, take someone with you and ask questions, and don’t let them put anything in your IV without Googling it!!!!! This is the next day, and still not 100%."
- Nel...
- Taken for less than 1 month
- March 25, 2017
For Nausea/Vomiting "I was in and out of the ER due to migraines, and on the last day, they gave me a prescription of Compazine. The next day when I took it, I laid down to take a nap and woke up struggling to breathe. My throat was closing, and I could barely talk. I went into a full-blown panic attack and called the ambulance. They gave me three different shots of something I can't remember and rushed me to the hospital. My jaw felt locked, like I was clenching my teeth hard together by the time I got to the hospital. I was shaking uncontrollably and crying hysterically. After I was discharged, I came home and chugged some children's Benadryl and took some Xanax and felt the side effects slowly go away. I have never in my life felt so scared."
Are you taking this medicine?
Your review helps others make informed decisions.More about Compazine (prochlorperazine)
- Check interactions
- Compare alternatives
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Support group
- Drug class: phenothiazine antiemetics
- Breastfeeding
Patient resources
- Compazine (Prochlorperazine Oral) advanced reading
- Compazine (Prochlorperazine Rectal) (Advanced Reading)
Other brands
Professional resources
- Compazine prescribing information
- Prochlorperazine, Prochlorperazine Edisylate, Prochlorperazine Maleate (Systemic) (Antiemetic) (AHFS Monograph)
For Anxiety "Went to the ER for a headache along with depression and was given Compazine through an IV and has been feeling detached from reality ever since last year in November. Anybody else feels this way after taking this medicine, and what do I need to do to get back to normal? All I do is cry and wonder why the doctors didn't warn me before taking this."