Pazopanib and Weight Loss: What Users Say

• eki...
• Taken for 2 to 5 years
• November 20, 2013

Pazopanib for Renal Cell Carcinoma "Have been on Votrient now for over three years and am in remission. Side effects have included hand and foot pain (very slight now) and have experienced weight loss (from 180 lbs to around 130 lbs) over the last three years. As of this year, there have been no signs of liver problems but have had minor digestion issues. It appears that Votrient has been successful - unlike my experience with Sutent, Avastin, Xeloda and Affinitor. I had been diagnosed with stage IV renal cell carcinoma-sarcomatoid in 2008, and had the left kidney removed (and spleen due to a fall in the hospital). I have been on Votrient now for the better of three years, am still employed and fully functional."

• eki...
• Taken for 2 to 5 years
• August 22, 2013

Pazopanib for Renal Cell Carcinoma "On Votrient since 2010 after Sutent. Results were good. After six months - no sign of metastasis and have been in remission since 2012. Votrient had the effect of high blood pressure which was mitigated by Procardia. As of late, have lost weight and am having some digestive issues."

• ano...
• Taken for 6 months to 1 year
• March 9, 2015

Pazopanib for Renal Cell Carcinoma "Began 800mg in May 2014, 10 months into treatment. No new mets at this time. High blood pressure began three weeks into treatment, a good sign in that it demonstrates the drug is working well. Hand-foot syndrome, initially intense pain, but now under control. Weight loss due to loss of taste and appetite, a nutritionist can help. White hair. This is considered the least toxic targeted therapy drug for mRCC, do all you can to stay with it. If it is working for the first year, you may continue to get excellent results for years to come. This is currently considered the first-line therapy for mRCC. Take at night to reduce the stomach discomfort."

• PAp...
• Taken for 1 to 6 months
• January 7, 2015

Pazopanib for Renal Cell Carcinoma "Unfortunately, side effects for me have been horrific! I was on 800mg for 6 weeks. I wound up with nausea, extreme hoarseness, high blood pressure, fatigue with sleeping 18 to 22 hours a day. Took a turn for the worse and liver enzymes were high. Could not eat or drink water for 5 days and lost 30 pounds. I was off the Votrient for a month and just started back on half the dose, 400mg. So far so good, one evening of slight nausea. Other than a little more tired, it appears to be better."

• Cle...
• April 25, 2020

Pazopanib "I started on Votrient in mid-January for neuroendocrine tumor and have been on it for a little over 3 months at 600 mg a day. It was rough at first. Felt bad, upset stomach, diarrhea, mouth sore, food tasted bad, and all my hair turned white. Lost weight as well. My blood counts were not affected and only slightly raised my blood pressure. I have toyed with when I take the medicine to try to mitigate symptoms. A couple of times I've stopped for 4-5 days due to horrible diarrhea. It would clear up after 24-48 hours of stopping the medicine. My taste would return as well. After 3 months, I now take the medicine around 3 AM or when I wake up to use the restroom in the night, when my stomach is most empty. This made a huge improvement. I always take 2 Imodium before breakfast, 1 before lunch, and 1 before dinner. This leveled out the diarrhea. Other than my white hair, all other symptoms have mostly subsided and I am able to carry on as normal. CT scan coming up next month."

• Des...
• Taken for 1 to 6 months
• December 5, 2016

For Renal Cell Carcinoma "Had radical nephrectomy August 2014, and I was clear until January 2016 when spots were found on both lungs. Had operations to remove the cancer on the lungs (big mistake). Cancer returned within 6-8 weeks. Started pazopanib 5 months ago. It's working! Lung spots have shrunk. Side effects seem to come in waves for me. I'll have a few weeks of normal bowel, then I'll have a week or so when it's bad. Hair has turned white (I'm 47). Bad taste in my mouth, I've lost weight (10 lbs), appetite comes and goes, but it's mainly not there. Ulcers in my mouth have gone, but I can't get rid of the ones in my throat. Blood pressure is normal. I feel tired at the end of the day (earlier than usual), but no real fatigue. Overall, I'm feeling good and still working. Keep fighting all, God bless."

• rcb...
• January 30, 2011

Pazopanib for Renal Cell Carcinoma "Very effective. Have lost a lot of weight, but side effects not as extreme as Sutent for me. Started taking 9/20/10 still on it 2/11."

• lll...
• Taken for 1 to 6 months
• May 21, 2018

Pazopanib for Renal Cell Carcinoma "With Votrient, I had no major side effects, only loss of appetite and weight loss so far. Slowed progression of cancer down significantly."