Pazopanib and Nausea: What Users Say

• Mrs...
• Taken for 6 months to 1 year
• June 24, 2013

Pazopanib for Soft Tissue Sarcoma "I am currently battling mesenchymal chondrosarcoma. It originated in my right thigh in 2008, had the tumor removed, was cancer-free for 3 years, then was diagnosed last year with it again, with 5 tumors this time which had spread in my pelvic area, right lung, and right armpit (July 2012). I've tried a few chemotherapy treatments and during that time frame, the tumors grew plus one new one appeared. In August 2012, I was placed on Votrient (800 mg), the tumors stopped growing and have been stable ever since. My last scan was June 11, 2013, and all 6 tumors are still holding stable and have shown some shrinkage. The side effects come and go, I am experiencing more muscle pain throughout my body and still some nausea, but that's easily controlled."

• PAp...
• Taken for 1 to 6 months
• January 7, 2015

Pazopanib for Renal Cell Carcinoma "Unfortunately, side effects for me have been horrific! I was on 800mg for 6 weeks. I wound up with nausea, extreme hoarseness, high blood pressure, fatigue with sleeping 18 to 22 hours a day. Took a turn for the worse and liver enzymes were high. Could not eat or drink water for 5 days and lost 30 pounds. I was off the Votrient for a month and just started back on half the dose, 400mg. So far so good, one evening of slight nausea. Other than a little more tired, it appears to be better."

• Deb...
• June 17, 2016

Pazopanib for Renal Cell Carcinoma "I had my right kidney removed in December 2014. They thought all the cancer was gone, but a few months later they found cancer in my lymph nodes. I started on Votrient in July 2015 at 800 mg but had my doctor reduce the amount because of stomach issues. I'm still nauseated daily and throw up almost every day. My hands are bright red, my hair is white, and I have sores on certain parts of my body that act like blisters then go away after a few weeks. All in all, the cancer is shrinking, and I have another CAT scan this month."

• Bel...
• Taken for less than 1 month
• March 17, 2013

Pazopanib for Soft Tissue Sarcoma "I have started taking Votrient about three weeks ago. One tablet in the morning, one tablet in the afternoon, and one tablet before bedtime. I would be sick during the day (nausea, extreme fatigue, and no appetite.) I told my doctor about my experience and she suggested to take the tablets all at once before going to bed. I have been doing this for a week, and it is not too bad except waking up in the morning feel exhausted. But in the afternoon I would feel fine. I think the medication is working because I always have tumor pain and I will be going to the doctor this week for signs of some shrinkage."

• elw...
• November 17, 2014

Pazopanib for Soft Tissue Sarcoma "Wife is on this now for her 4th week (800 mg), she has soft tissue in the right lung after mets from the uterus. Leiomyosarcoma (sp). A month ago, she was coughing every 2 minutes, now, not so much, but she is tired, has nausea, and headaches. No appetite, and when she ate solid food, it would always come back up. Now her food consists of 4-6 smoothies a day. Got a Vitamix after many recommended it on other websites on the internet. You fellow patients who have gone before her and have reported your experiences are the 'only' thing that have kept her pressing forward. She has a large tumor in her chest, and it is hoped that this will hollow it out or something. Her first chemo, GEMS/Taxol, only worked for 3 months. Then it started regrowing."

• Kat...
• Taken for 5 to 10 years
• December 15, 2020

Pazopanib for Soft Tissue Sarcoma "I'm taking Votrient for over 5 years, it stopped the spread of mets. Just before I started the trial, every scan like MR, CT, PET was showing new mets. I had clinical chemo like doxorubicin, ifosfamide, and it stopped only for a while. My oncologist was always suggesting Votrient, but it’s the 4th line treatment and expensive for the government (complicated to explain when health care is for “free” in my country). Anyway, for me, it was the last option. The regional CEO oncologist refused me the treatment. But my oncologist is a researcher and sent me to a capital hospital. So that since 18.9.2015, I’m on Votrient. First of all, I had no side effects, then, after half a year, I started having nausea, diarrhea, fatigue. And of course, my skin is as pale and cannot find the lightest foundation tone, and color my hair and henna brows and lashes..."

• G-G...
• Taken for 6 months to 1 year
• July 1, 2017

Pazopanib for Renal Cell Carcinoma "Had a partial nephrectomy of the right kidney in 2005. The tumor was papillary renal cell. In Jan. 2016, the cancer reoccurred in several locations in the omentum. Surgery in June 2016 removed a portion of the frontal omentum including papillary renal cell tumors. Multiple nodules still remain in the omentum on both sides of my body. Have been taking 600 mg of Votrient since Nov. 2016, now 8 months. Shrinkage by as much as 50% has occurred in some tumors. None have increased in size during the period. Some initial side effects, hypertension, nausea, and weakness, have improved during the period; others, diarrhea, taste, and poor appetite, remain. At the age of 87, I am trying to stay active. Praying for improvements for all of us."

• Kid...
• Taken for 6 months to 1 year
• November 28, 2016

Pazopanib for Renal Cell Carcinoma "My husband was diagnosed with right renal cell cancer in May 2014. A brain tumor was found on an MRI that same month, along with small spots on the lungs. Gamma Knife procedure done in May 2014. Right nephrectomy in June 2014. Brain tumor removed in September 2014. He didn't start Votrient 800 mg until December 2015 due to a small spot they found on the left kidney during a routine CT scan. Since taking the medication, his hair has turned from red to white. Other side effects include high blood pressure, nausea, diarrhea, and being tired. He was on blood pressure medication prior to taking Votrient. Now he is on three blood pressure meds, and now the blood pressures are within a normal range. Spots may or may not be cancer. So far, tolerating the med well."

• Anonymous
• July 24, 2016

For Renal Cell Carcinoma "My husband started 800 mg Votrient 12 months ago, 3 months post-right renal nephrectomy with grade 4 renal cell carcinoma nodules in both lungs. CT scans 3 months later showed all nodules had shrunk, the last 3 CT scans have revealed no change, and he is stable. BUT he is suffering from massive bouts of diarrhea, as in some days/nights 10 or more times. He finds drinking the required amount of water makes him nauseous, but he looks dehydrated, pale, and is lethargic. Because of the urgent diarrhea, he is always worried about going places unless he knows where he can rush to the toilet, so he tends not to go far, so this really impacts his life. He also has vomiting at times. His specialist only says to take anti-diarrhea tablets and prescribed Maxalon."

• Anonymous
• December 27, 2021

Pazopanib for Renal Cell Carcinoma "My husband had a nephrectomy of his left kidney, it had spread to his left testicle, and he had the testicle removed as well. Before the operation, the surgeon said that the mass had been slow-growing for roughly ten years. He is 67 and in mostly good health outside of the cancer. It has been a year and a half on Votrient. The first dosage was too high and caused him a few hospital visits to stabilize his liver function. Now he is on half that dose, the only prominent side effect is the occasional nausea, fatigue, and vomiting/fainting spells. Of course, his hair has also gone completely white. He is very thin and struggles to put on weight but has a healthy appetite. It seems that this dosage is working, his cancer cells have shrunk. He goes for a PET scan twice a year and has been clear so far. In 4 months, it will be 2 years since diagnosis. So far, the medication is working. The diet seems to be the trickiest part, and I would recommend that you see an expert dietician. A specific diet is NB."

• For...
• Taken for 1 to 6 months
• November 24, 2021

Pazopanib for Renal Cell Carcinoma "Daddy has clear cell renal cell carcinoma. He was first put on Opdivo and Yervoy-an immunotherapy. This worked great! It was shrinking my dad's tumors that he had in his stomach, liver, lungs, and right atrium (heart). It even got rid of all the cancer in his stomach. The cancer spread to his brain, and he had to be put on chemotherapy. Votrient had a lot of side effects: nausea, super high blood pressure, major fatigue, and chemo brain fog. He lost 80 pounds on Votrient from not eating. Became frail and fragile, and we were afraid he would die from malnutrition. We begged the doctor to take him off it because she even said he wouldn't live much longer on it, but the issue was the Votrient was SHRINKING the tumors in his liver. This was a sign it was working. His doctor put him on dexamethasone 2 mg, which helped his energy levels and his appetite tremendously. He gained 40 pounds! He was on Votrient 6 months, but BP and brain fog got worse, though, so she then put him on Avastin."