Naldemedine and Vomiting: What Users Say

• Pam...
• February 16, 2020

For Opioid-Induced Constipation "I started taking this three days ago. I tried Movantik a while back, and every time it made me nauseous, and ultimately I would vomit. I did poop, however. The first couple of days I took Symproic, it worked like a charm. On the third day, I did get some cramping and diarrhea, but since I’d barely gone in two weeks, I figured I needed a good cleansing! So, keeping in mind it’s only been three days, I highly recommend. I’ll post again after I’ve used it a while. Good luck!"

• Dia...
• April 10, 2018

For Opioid-Induced Constipation "Background: 6 ft tall male, 37 yo, 210 lbs, type 2 diabetic, father of 3, IT tech, MBA. Review: This stuff is awesome. Had to go to the ER 3 times in the last 12 months for dehydration, abdominal pain, vomiting, migraines, and an overall very sick feeling, only to be told I was constipated. I am not sure about the other review because my experience is completely different from their description. It's like it's COMPLETELY NATURAL, but it works, EVERY TIME LIKE CLOCKWORK! Where before, when using OTC meds and eating pudding, it would take days and hours of excruciating pain on the pot trying to desperately force out a dinosaur-sized egg and feeling terrible like my body was poisoning itself. Get rid of that cheese and meat, baby, TODAY!"

• Not...
• January 18, 2018

For Opioid-Induced Constipation "I had eaten a high-fat small meal prior to taking for the first time - within an hour of taking the SYMPROIC 0.2 mg tablet, I began to feel nauseated, which was escalating - I was on the verge of vomiting for another 20-30 minutes & had begun having quite intense abdominal cramping & pain with sudden intense frequent diarrhea & sweating & significant dizziness & fatigue - I continued to have intense nausea & abdominal pain & dizziness & I could barely keep my eyes open & then sweats & chills. I then vomited intensely 2 times & had 2 more episodes of watery diarrhea & was still dizzy & very fatigued. I have had a headache & experienced some episodes of a heaviness in my chest & vomiting & diarrhea have ceased. I had a significant BAD reaction."

• Pam...
• Taken for 1 to 6 months
• April 22, 2020

For Opioid-Induced Constipation "So, when I first started taking this Symproic, I thought I’d found a miracle drug. Then, the night before last, I got stomach cramps and vomited. Yet, I still didn’t go. Went back to bed, got up like three times, and finally I went. I plan on taking this only if I haven’t gone in several days. These side effects are just awful. I’m envious that some of the people on here have had no side effects!"

• Evy...
• Taken for 1 to 2 years
• June 1, 2025

For Opioid-Induced Constipation "I was a heroin addict, who has now been on Sublocade/Suboxone for almost 10 years. I already suffer from idiopathic constipation (cause unknown). So, the opioid-induced constipation has been hell for me. I mean hell. Taking every over-the-counter drug that exists to relieve myself. Not going for up to 2 weeks at a time. Linzess helped, but made me very bloated. Amitiza didn't do anything. As soon as my doctor gave me samples of Symproic, it worked like a miracle drug. No cramping or vomiting, no withdrawal symptoms, just bowel movement within 1-3 hours. I have taken Relistor, Movantik, and Symproic. I'd say that Symproic works the best, followed by Movantik. It seems from the reviews that I've read that this drug works best for people on Suboxone, not Oxy/Percs or other opioids. If you're struggling with OIC, Movantik and Symproic can be miracle drugs. It's unfortunate that it seems up to 20% of people have a bad reaction to this drug."