Skip to main content

Misoprostol and Nausea: What Users Say

Brand names: Cytotec

Nausea: mentioned by 204 users (28.2%)

Based on user experiences from 723 Misoprostol reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

cramps 70.8%
bleeding 35.0%
nausea 28.2%
pain 22.5%
diarrhea 20.6%
vomiting 12.7%
chills 7.5%
blood clots 5.9%
sweating 3.9%
severe pain 3.7%

Reviews for Misoprostol

Commonly mentioned side effects
  • Anonymous
  • Taken for less than 1 month
  • July 19, 2021

For Abortion "I’m 22 years old and it’s my first time getting pregnant. I was so scared about taking the pills. I was 6 weeks pregnant when I took the first pill at 9:00 am. A few hours later, I started bleeding. I was nauseous, passing gas, and had palpitations. Still, I waited for 36 hours and then inserted the second pill vaginally. I was given a pain relief injection (diclofenac). Four hours after inserting the misoprostol, I had cramps, not even half as intense as my normal period cramps. I went to the toilet, saw the first blood clot, and a few minutes later, I passed something like a sac, then another blood clot the size of a walnut, and then the cramping stopped. I had moderate bleeding. It’s been 2 days now, and I'm just having very light bleeding. My experience was smooth, but everyone is different. Do not think about it too much. You can do it, girl."

5 / 10
Was this helpful?YesNo
896 Report
  • Mea...
  • July 17, 2021

For Abortion "I'm 39 with 3 kids. Got pregnant. By 6 weeks, I was miserable with fatigue and feeling so sick. At 6 wks 5 days, I decided I can't do it anymore. I went to a clinic while on vacation in Florida. Got the first pill on Thurs at noon. On Fri, I felt very nauseous, had a few cramps. By Friday at 3:30pm, I had light bleeding and bloody watery fluids. Soon after, I had two ping pong ball-sized clots. About 8pm, another one passed out. No pain, just slid out. The morning sickness calmed down a lot. I was certain I passed it. Took misoprostol at midnight in cheeks. Right before, I took a piece of Phenergan for nausea and half of a 7.5mg Vicodin. Went to sleep. Passed a small clot with bloody fluid at 2am. No pain. On Saturday morning, I was bleeding like a heavy period. Being in a toxic relationship and feeling so terribly sick, and being very content with the children I have, helped me come to my decision. I don't feel any regret at this time. Hugs to all reading this. Hope it helps."

10 / 10
Was this helpful?YesNo
643 Report
  • nru...
  • March 7, 2021

For Abortion "I hope this helps other women looking into this route for medical abortion. I was 2-3 weeks pregnant when I was given the prescription. I took the first pill in the clinic on a Friday afternoon at 2 pm. I had no reaction at all. On Saturday, I took four pills in my mouth and let them dissolve. I also took Gravol/Advil beforehand. I experienced mild cramps and mild nausea. I had no bleeding. I was worried the meds weren’t working because I wasn’t bleeding and had no clots. My abdomen was distended, but the bleeding and cramping did not begin for 48 hours. Very little bleeding, some small clots, and little tissues passed. My belly was rock hard, and I had a lot of bloating. I kept googling why I wasn’t having a lot of bleeding and felt scared I would need to repeat this. A week later, I went to get my blood work, and the clinic confirmed the meds worked. I’m still fatigued with very little bleeding. Stay calm, treat yourself well, have comforts with you and all will be ok. Xox"

10 / 10
Was this helpful?YesNo
467 Report

Frequently asked questions

  • Cat...
  • Taken for less than 1 month
  • August 27, 2021

For Abortion "I was so scared to take this from the bad reviews. I cried so much, but I want to let others know of my experience because I wish I had read this. I took my first pill orally at 5:30 pm on a Fri, and I didn’t feel any pain or bleeding, just some bloating and dizziness but that only lasted a couple of minutes. I took my second pills all orally at 5:50 am on a Sunday with pain relief 20 minutes beforehand. I then slept until 9 am. When I woke up, I felt cramps, went to the toilet, passed 2 clots, and felt a bit nauseous. My cramps worsened for the next 30 minutes but were still bearable, then I went to the toilet, passed 2 more clots, and felt almost instant relief. I think that’s when I passed the pregnancy. I still bled quite heavily after that and passed clots throughout the day, but the cramps lessened, and I just chilled and watched some movies. I was so happy with how smoothly and bearable it all went. You are so strong, girl, you can do this! Please don’t be scared, sending you my love x"

10 / 10
Was this helpful?YesNo
176 Report
  • Li_...
  • June 7, 2021

For Abortion "I was 8 weeks pregnant. I took the first pill at the doctor's office at 2 pm on a Friday. I didn't feel anything at all for that one. I took the other four in my cheeks the next day at 9 pm and by 9:30, they were mostly dissolved, but I washed it down with water. The only pain medication I took was ibuprofen 30 minutes before. As soon as it dissolved, I noticed a little bit of cramping for like 20 minutes and I also threw up my meal. But that was the only time I threw up, I didn't feel any nausea. My cramping started to get worse for the next three hours. I was sitting on the toilet for like 40 minutes with diarrhea and cramping with only a bit of blood. By 12:00 am, I was bleeding more and passed four clots. After that, my cramping had stopped, and then I was just bleeding like a normal period. Just have some water, relax, and a heating pad, and you'll be fine! Don't let these bad stories scare you away."

10 / 10
Was this helpful?YesNo
149 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Anonymous
  • August 27, 2020

For Abortion "I thought I would share my experience! I took my first 4 tablets vaginally yesterday at 12pm, had some light cramping and a little nausea but nothing else. Took another 2 at 4pm vaginally.. again, apart from cramping, nothing major! Started getting chills and fever that lasted about 3 hours but was bearable. Today I have woken up, still no bleeding! Ended up in A&E as I felt it was not working and am now being sent for an emergency scan tomorrow morning with potential of an operation :( I was only 5 weeks I’m so scared and confused. I feel a little dizzy today and lethargic but more anxious over the fact it’s been 29 hours and I still have not bled! Hope you guys have a better experience xo"

1 / 10
Was this helpful?YesNo
175 Report
  • Sus...
  • Taken for less than 1 month
  • February 6, 2022

For Abortion "I put 2 pills under my tongue and inserted 2 vaginally. I did not see any blood, not even any spotting for more than 24 hours, so I had to use 4 more tablets of misoprostol (Misoclear). It's been more than 4 hours and I have not yet felt any pain, not even cramps or nausea. I am only 3 weeks pregnant. I'm scared the tablets aren't working."

1 / 10
Was this helpful?YesNo
84 Report
  • May...
  • February 4, 2021

For Abortion "I was 8 weeks pregnant. In the medical center, they gave me the first pill and told me that I could expect nausea and bleeding, however, I didn't have any symptoms. I came back 48 hours later, and they inserted 2 pills into my vagina and 1 in my anus for pain relief, instructing me to lie in bed for 2 hours. After 4 hours with no changes, they gave me 1 more pill to dissolve under my tongue. Around an hour later, I went to the bathroom and something gushed out of me with a little blood. I went for an ultrasound, and they confirmed the abortion was successful. I experienced bleeding for about a week afterward, similar to a normal period. I didn't have any pain or cramping, which was surprising to me, as my periods are usually more painful. It seems that everyone's experience can vary. Wishing you good luck."

10 / 10
Was this helpful?YesNo
74 Report
  • Nat...
  • Taken for less than 1 month
  • August 19, 2020

For Abortion "I was 6 weeks 2 days pregnant, and this was my first abortion. I took mifepristone first, which only caused some nausea and tiredness. The next day, I inserted vaginally 800mg of misoprostol. I started feeling light cramping and bleeding 40 minutes after inserting the pills vaginally, the cramping did increase a bit but nothing crazy! About 1 hour and 30 minutes later, I passed the sac and a gush of blood just came out. It took me by surprise because I was expecting some intense cramping before the sac would come out, but this wasn’t the case. I freaked out when I saw all the blood and the sac. It took me about an hour to calm down, but my whole experience wasn’t horrible. I experienced menstrual-like cramps/bleeding throughout the day and lower back pain, also lots of little blood clots. I’ve learned my lesson and will not allow this to happen to me again."

10 / 10
Was this helpful?YesNo
80 Report
  • 142...
  • Taken for less than 1 month
  • August 8, 2020

For Abortion "I’m 20 years old with a very strong stomach. I took the first pill at the clinic around 11:30. I was tired and slightly nauseous but I was prescribed promethazine, which helped with the nausea. By 9 am the next morning, I was bleeding a small amount. I decided to eat a meal, take 800 mg of ibuprofen that I was prescribed, and another promethazine for nausea. 45 minutes after taking the pain medicine and nausea medicine, I placed 2 cytotec in each cheek, which dissolved in 15 minutes. I felt the most intense cramping and pain and was honestly screaming in agony. The pain was so severe I threw up everything in my stomach and had diarrhea. This all lasted about 30 minutes and then I began to do breathing exercises that helped calm the pain and made me fall asleep. After that, I had very moderate cramping that was very manageable. Drink lots of water, sleep a lot, and stay calm. You can do it."

7 / 10
Was this helpful?YesNo
83 Report
  • Anonymous
  • August 29, 2020

For Abortion "I was 7 weeks 6 days and this was my first abortion. Took the first pill at the clinic and the next day took nausea and pain meds before putting the 4 pills in my cheeks to absorb. After taking all the pills, I threw everything up right away. I started having mild cramps about an hour later. Went to the bathroom when they got more severe and threw up again, the cramps were extreme for about 30 minutes, and I threw up 2 more times until bile was coming out. It was very painful for me, but it didn’t last too long. I passed 3 large blood clots before the baby sac came out, and then the cramps immediately subsided. I had heavy bleeding for the rest of the day, and by the next day, I felt back to normal. It’s been 2 weeks, and I’m still bleeding, but it’s a very light amount now. If you can keep down the pain meds, then I’m sure it won’t be nearly as painful. I felt so relieved after, but still a little sad and depressed about the reality of the situation. Good luck, you will be okay :)"

10 / 10
Was this helpful?YesNo
70 Report
  • Nic...
  • October 4, 2020

For Abortion "The baby's heart stopped beating around 9 weeks (measured 6 weeks 2 days). I decided to go for medication versus D&C. I woke up at 5:30am and took nausea medicine, 5 mg oxycodone, and 800 mg ibuprofen. I had a light breakfast, and 30 minutes later, I inserted the medication vaginally. I was able to fall back to sleep. Cramps started first, and 30 minutes later, the bleeding began. From 10:30 to 11:30am, I’d say my pain was a 6/10. It wasn’t fun, but it was manageable. I took the next dose of pain relievers and was able to fall back asleep until 1pm. I used the restroom and passed the sac. The cramping reduced down immediately after. I’m in little to no pain now, just bleeding a lot. I’ve been taking it easy all day. So, I definitely recommend taking it in the morning on a day you can spend just laying around. I had no nausea, no diarrhea, no chills, no fever. It honestly wasn’t half as bad as I hyped myself up to believe it would be! You’ve got this, ladies!"

10 / 10
Was this helpful?YesNo
60 Report
  • Jes...
  • June 21, 2020

For Abortion "Every woman is different, but I hope this helps. I was 6 weeks pregnant, nervous, and very upset. I took the mifepristone and felt slightly nauseous but fine. I took 4 tablets of misoprostol 24 hours later. I took them vaginally; the leaflet says that dissolving them by mouth increases the chance of sickness and diarrhea. I only had slight cramping and light bleeding. I kept hydrated and relaxed on the sofa. I took 30 mg of codeine before taking the misoprostol. I took the next 2 tablets vaginally, 4 hours later with 30 mg of codeine. I had stronger cramping, like having moderate period pain for a prolonged amount of time. I used a hot water bottle. The bleeding was now heavier but not horrendously so. I didn’t feel nauseous, but I felt just slightly feverish and shaky. From taking the tablets at 3:30 pm, I was having cramps at midnight; for me, they were completely bearable. They began to subside. I went to bed at midnight and woke up the next day feeling fine. Hope you are all okay."

10 / 10
Was this helpful?YesNo
61 Report
  • Tin...
  • September 18, 2020

For Abortion "Was 7 weeks in when taking mifepristone, felt slightly nauseous. 24 hours after, took misoprostol vaginally and codeine (30 mg) for pain management. Got to bed and just waited. Light cramping after an hour, with stronger cramping and abdominal pain after 3 hours, pain 5/10. Did feel lightheaded when getting out of bed to go to the toilet (my boyfriend helped me navigate from the bedroom to the toilet). When I did get to the toilet, that’s when I saw blood clots and the actual pregnancy. Got rid of it, showered, changed the pad, and got back to bed. Cramping stopped, felt so much better. Took another 2 misoprostol pills vaginally. Light cramping an hour later. Fell asleep shortly after, and the next morning woke up feeling great. Would recommend getting a heating pad and having an abortion in the evening, that way you can relax in bed and sleep after it’s all over. It’s not that scary nor painful. Of course, everyone is different, I’m used to painful periods, and this felt just like that."

10 / 10
Was this helpful?YesNo
46 Report
  • Met...
  • October 18, 2020

For Abortion "The next day I was told to insert the 4 misoprostol pills in my vagina any time after 2:30 pm. I was very nervous for the oncoming pain I had read about, so I took 1 oxy 10/325 at 2 pm just to be safe, as I have a very low pain tolerance, so I couldn't bear having the pain. I also took 1 ibuprofen 800 at 1:30 pm, as well as the nausea pill promethazine. After I inserted the pills, I laid down for 30 minutes and didn’t feel anything until 5 pm. I started feeling some cramping. I fell asleep because of all those drugs, I’m assuming, they made me really sleepy. I woke up at 7 pm exactly with excruciating pain. I took another oxy and a nausea pill. Fell asleep about 15 minutes later with that pain still going. I woke up around 8:30, and I had no pain whatsoever. I got up to use the restroom, and boom, everything came out. I did pass the sac then, I could see it. After that, there was no pain at all. It’s the next day now, and I feel completely fine. Still some blood coming out, but none like the day before."

10 / 10
Was this helpful?YesNo
44 Report
  • Man...
  • October 3, 2020

For Abortion "I was 5 weeks and 3 days. I read the reviews on here and almost talked myself out of it, but I had to do what was best for me. I spoke with 4 friends who also took this route, and they all said it was awful. I was terrified. I took the first pill to stop the pregnancy from growing on Friday at 10 a.m. There was some light cramping. I threw up my dinner that night and had slight nausea. I then took the other 4 pills on Saturday around 12:18 p.m. and swallowed the remaining at 12:48 p.m. Soon after I felt super mild cramping and just relaxed. I went to the restroom around 1:30, no blood, I went back around 2:15 and there was bleeding. Still no severe cramping. Around 3:55 p.m. I went to the restroom and felt clots and a couple plops in the toilet, I had passed the pregnancy. It is now 7 p.m. and I am just relaxing, slight cramping right now. Bleeding is heavy. Before taking the 4 pills today, I ate applesauce and took 4 ibuprofen. I drank lots of water and just took it easy."

10 / 10
Was this helpful?YesNo
40 Report
  • Sam...
  • June 6, 2020

For Abortion "I took the first pill around 3:30 pm. Most people on here would say they felt nothing with the first one, but it was the absolute worst part for me. I was extremely nauseous, thinking it was just the hot weather/pregnancy. But when I got home to the A/C, I still felt horrible. I went to bed feeling horrible and woke up the next morning feeling worse. It made me scared to take the next four pills. After forcing myself to throw up, I still felt awful. After using a heating pad later in the afternoon, it helped a lot along with a warm shower down my back. At 7:45 pm (approx. 28 hours later), I put the four pills in my cheeks for 30 minutes, then washed them down with water. Prior to that, I took Naproxen and Tylenol 3s 30 minutes before. I kept the heating pad on all evening. One hour after washing the pills down, I started bleeding. I passed a few clots in the toilet the size of a lime. It wasn’t as painful as I anticipated. It felt just like a period. Painkillers and the heating pad were essential! Good luck, ladies."

9 / 10
Was this helpful?YesNo
44 Report
  • tha...
  • July 29, 2019

For Abortion "I’m sharing my experience because I was really nervous after reading reviews. I'm glad I did it though. My experience overall was good. I took the 4 pills orally (inside cheek). The cramps hit an hour after taking the medication. Then I got bad diarrhea for about 4 hours. I had visited the bathroom at least 5 times within those 4 hours. I started bleeding until 2 hours after taking the pills. Honestly, the bleeding was exactly like a heavy period. My cramps just felt like bad period cramps. I didn’t take any pain medication, and I didn’t use a heating pad. I was exactly 5 weeks when I took the pills. My doctor said that’s why my cramps weren’t as bad. The heavy bleeding stopped 24 hours later. I had normal period bleeding for a week and then light bleeding for another week. I bled for exactly 2 weeks and then it stopped. I was relieved. The pregnancy symptoms: nausea, breast tenderness, and bloating took a week to go away."

10 / 10
Was this helpful?YesNo
45 Report
  • Aly...
  • Taken for less than 1 month
  • July 27, 2019

For Abortion "So just like everyone else was TERRIFIED to take the pill after reading reviews. Everyone is obviously different, but it was so much better than I anticipated. I took the pills and got cramping while I kept them in for 25-30 minutes. However, as soon as I swallowed them, I got the worst cramps ever, I did throw up once. I did take the ibuprofen, nausea medicine, and the Tylenol 30 minutes before I took the 4 pills. My cramping lasted about 10-15 minutes, and then I fell asleep for 2 hours. When I woke up, I didn’t have even blood on my pad, so I was nervous it did not take, but as soon as I stood up, that’s when it started happening. It’s been about 5 hours since I took the pills, and I’m completely fine. No cramping, nausea, or pain at all. Just like a SUPER heavy period. I would recommend a heating pad and maybe just someone to be with you for support. But seriously, don’t freak yourself out like I did by reading the bad reviews. Side note: I was 7 weeks and 5 days."

10 / 10
Was this helpful?YesNo
45 Report
  • San...
  • January 24, 2020

For Abortion "I had to leave a review because I can't believe how bad some of these are. Some sound so scary, and I don't want people to read these and get scared off. First, pain medication does NOT interfere with this. I was 5 weeks. I was given the first dose in the office and prescribed nausea meds, 800 mg Ibuprofen, and Tramadol. 24 hours later, I took the nausea meds and Ibuprofen an hour before I put the 4 pills in between my gums and cheek. I had started light spotting. 30 minutes later, I swallowed what was left of the pills. Within 15 minutes, I passed a lemon-sized clot. Cramping was like a bad period. I did take 1 Tramadol, and it made me sleepy. I used a heating pad and had one bout of diarrhea, no nausea. I passed small clots and have been bleeding, but no other large clots. I have a follow-up ultrasound to confirm it worked. This wasn't as bad as some of the other reviewers experienced, and I want people to know that everyone will have a different experience."

10 / 10
Was this helpful?YesNo
41 Report
  • Cja...
  • Taken for less than 1 month
  • February 29, 2020

For Abortion "Don't let any of these reviews scare you!!! I was terrified to take this medicine after reading all the reviews, and I mean terrified. I took the first pill before leaving the doctor's office at 2 pm. The next day at 11, I took 800 mg ibuprofen and promethazine for nausea. At 11:30, I stuck the 4 pills in my mouth, 2 on each side and let them dissolve for 30 minutes, then swallowed with water. As soon as I swallowed, I started cramping as if it was the first day of my period, I started bleeding at the same time. After about an hour, the cramping had stopped. I had no nausea, possibly due to taking anti-nausea before. I did experience a little stomach cramping as if I was going to have diarrhea, but never did. Only experienced heavy cramping for about an hour, and then the rest of the cramping was like a second-day period, and that was it. I almost opted for the surgical method, but I'm glad I chose medication and could be in my own home."

10 / 10
Was this helpful?YesNo
41 Report
  • lil...
  • June 21, 2020

For Abortion "Took the first pill in the office, didn’t experience any side effects other than some nausea. Twenty-four hours later, I took the last four pills at home. Immediately started bleeding and experienced intense and extremely painful cramping. No position could alleviate the pain. I was sweating profusely and threw up. I then got into the shower, and the hot water helped the cramps so much! That was my lifesaver. When I got out, I thought the pain was subsiding, but it came back, not as hard as the first hour and a half, but like your WORST period cramps you’ll ever have. They lasted another three hours, but the ibuprofen helped so much. I also used a back massager on my lower back. If you can suffer through an hour and a half of intense pain and then several hours of some cramping, you will get through it. You got this!!!"

10 / 10
Was this helpful?YesNo
37 Report
  • Man...
  • Taken for less than 1 month
  • March 1, 2020

For Abortion "Checking back in after the 2 doses of pills. My ultrasound following the 1 dose was not clear: “clots still remained but I passed pregnancy.” Ibuprofen and nausea meds 45 min before abortion pills. First-time experience was totally fine, except for the runs, and it wasn’t extreme painful runs neither. Relax, girls! Didn’t bleed right away as the first time! I was panicking, accepting I would need the procedure! But 24 hours later, bleeding started, lasted 2 days, normal period type. No pain! No vomiting! No runs this time! Just feeling drained. Clear ultrasound! Doctor approved me, and it’s all over now. Be strong!! I know this is a very traumatic experience, but don’t let them talk you into the procedure without doing a 2 doses first! Medical covered everything. I did mine at Planned Parenthood."

10 / 10
Was this helpful?YesNo
40 Report
  • Mac...
  • March 5, 2021

For Abortion "On 2/19, I was 6 weeks, 6 days. Swallowed pill 1 at 11 a.m. I opted to insert the next 4 pills vaginally. I took the nausea pills and ibuprofen once I ate and waited till 4:30 p.m. to insert the rest. Then went to sleep. I woke up at about 8:30-9 p.m., nothing. I was worried it wasn’t working. I went to the bathroom, wiped, and saw blood. At around 11 p.m., I began cramping. From 11 p.m. to 12:30 a.m., the cramping was at its worst but eased up a little when I sat on the toilet. Very few clots. I felt a strong cramp and then a release. I checked the toilet, and I saw 'it' pass. Next, the bleeding increased a bit, and I had a bowel movement. This all ended around 1 a.m. I immediately felt less bloated and gained some energy, it was weird. Now, 2 weeks later, bleeding was like a period for a week. Then spotting, mostly brown but sometimes dark red, cramping slightly at night, which is worrying me a little. Follow-up in a few days, process wasn’t bad. Honestly, just ready for my body to get back to its normal state. Good luck, ladies."

8 / 10
Was this helpful?YesNo
31 Report
  • Ab1...
  • Taken for less than 1 month
  • August 29, 2019

For Abortion "I'm sharing my experience to encourage those who are about to try the abortion pill. I was 6 weeks pregnant and wanted to do a non-invasive procedure, but reading the reviews here made me so hesitant and anxious. I did it anyway. I took the first pill in the doctor's office, this one was the worst pill, because it made me throw up all day, but nothing an anti-nausea pill couldn't solve. Make sure your doctor prescribes this to you. I then swallowed an anti-nausea tablet, 2 Nurofens along with the misoprostol. The trick to it was, as soon as I felt light cramping, I swallowed paracetamol and codeine that was prescribed by the doctor for pain relief. I'm glad to say my pain overall was like 2.5/10, slept through the bleeding, and about 4 hours later passed some clots, changed pads twice, passed more clots, and slept like a baby. It also helps to have someone there next to you for support, a hot water pack, hot chocolate, and some entertainment!! You've got this!"

10 / 10
Was this helpful?YesNo
40 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.