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Toprol-XL and Depression: What Users Say

Depression: mentioned by 4 users (6.5%)

Based on user experiences from 62 Toprol-XL reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 14.5%
tiredness 14.5%
fatigue 11.3%
heart palpitations 11.3%
insomnia 11.3%
shortness of breath 11.3%
depression 6.5%
dizziness 6.5%
drowsiness 6.5%
headaches 4.8%

Reviews for Toprol-XL

  • Sca...
  • Taken for 1 to 6 months
  • April 7, 2022

For High Blood Pressure "This is an update to a post I made in October 2021. I discontinued Toprol due to nasty side effects after only 2 months of use (severe anxiety, panic attacks, severe depression, insomnia, swelling of extremities, bloat/gassy, blurred vision, icy hands/feet, arrhythmia, shortness of breath, chest vibrations). It's been 1 year and 3 months since discontinuation. I am STILL experiencing off and on arrhythmia. I've had a thorough exam and testing with 30-day monitoring from 2 different cardiologists. My heart is very healthy, no blockages, no disease. Neither cardiologist can find any reason for the persistent arrhythmia, nor will they believe me when I tell them I think the Toprol caused this long-term persistent arrhythmia. I've also had extensive endocrinology testing and nothing is coming up as a reason for this arrhythmia. NOTE: I've never in my entire life had any heart arrhythmia or palpitations UNTIL I took Toprol, and now it's a regular occurrence. This cannot be a coincidence."

1 / 10
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  • Sca...
  • Taken for 1 to 6 months
  • October 30, 2021

For High Blood Pressure "DON'T TAKE THIS POISON!!! I was on it only 2 months. Weaned off as directed after experiencing horrible side effects (fatigue, shortness of breath, bloating/gassy, weight gain, joint pain, limb swelling, facial swelling) and went through an absolute nightmare getting off of this drug. I had severe panic attacks, anxiety attacks, depression, insomnia, arrhythmia, vagus nerve dysfunction, and chest vibrations. It has been 8 months since I discontinued this awful drug, and the arrhythmia continues on a regular basis. I never had any palpitations or arrhythmias ever in my life until I took Toprol, and now it's a daily problem. I fully regret ever taking Toprol. It was nothing but bad from the very first pill....."

1 / 10
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21 Report
  • POm...
  • February 8, 2009

"It's hard for a patient to 'rate' a medication. I have an excellent cardiologist whose job that is. However, I know that Toprol comes with a tendency toward depression for many people, and for me, pre-existing depression has been mildly exacerbated. I also take amlodipine since May of last year, and this is a drug also known to cause/increase depression. I take several other antihypertensive drugs, therefore, it is not easy to tell which is causing what. Welcome to life post-cardiac bypass surgery-a life diminished, trust me, but at least-LIFE."

7 / 10
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17 Report

Frequently asked questions

  • Pam...
  • Taken for 1 to 6 months
  • September 24, 2021

For High Blood Pressure "I'm on 400 mg a day. I have vision problems. There's a black half-moon shape in one eye, sometimes bright colors. I have nausea and fatigue every day, and depression. I can't stop, as it's for a previous aortic aneurysm. Just feel miserable and like I've got the flu every day."

3 / 10
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1 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.