Generic Name: metoprolol succinate tablet, extended release
Brand Names: Toprol-XL
Medically reviewed on September 13, 2018
What is Toprol-XL?
Toprol-XL (metoprolol succinate) is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins).
Toprol-XL is also used to lower your risk of death or needing to be hospitalized for heart failure.
You should not use Toprol-XL if you have a serious heart problem (heart block, sick sinus syndrome, slow heart rate), severe circulation problems, severe heart failure, or a history of slow heart beats that caused fainting.
Before taking this medicine
a serious heart problem such as heart block, sick sinus syndrome, or slow heart rate;
severe circulation problems;
severe heart failure (that required you to be in the hospital); or
a history of slow heart beats that have caused you to faint.
To make sure Toprol-XL is safe for you, tell your doctor if you have:
diabetes (taking Toprol-XL may make it harder for you to tell when you have low blood sugar);
congestive heart failure;
problems with circulation (such as Raynaud's syndrome);
a thyroid disorder; or
pheochromocytoma (tumor of the adrenal gland).
Do not give Toprol-XL to a child without medical advice.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether metoprolol succinate will harm an unborn baby. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating hypertension may outweigh any risks to the baby.
Ask a doctor before using Toprol-XL if you are breast-feeding. Metoprolol succinate can pass into breast milk and may cause dry skin, dry mouth, diarrhea, constipation, or slow heartbeats in your baby.
How should I take Toprol-XL?
Take Toprol-XL exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Toprol-XL should be taken with a meal or just after a meal.
Take the medicine at the same time each day.
Swallow the extended release tablet whole and do not crush or chew the tablet.
A Toprol XL tablet can be divided in half if your doctor has told you to do so. Swallow the half-tablet whole, without chewing or crushing.
You will need frequent medical tests, and your blood pressure will need to be checked often.
If you need surgery, tell the surgeon ahead of time that you are using metoprolol.
You should not stop using Toprol-XL suddenly. Stopping suddenly may make your condition worse.
If you have high blood pressure, keep using Toprol-XL even if you feel well. High blood pressure often has no symptoms. You may need to use metoprolol for the rest of your life.
Store at room temperature away from moisture and heat.
Toprol-XL dosing information
Usual Adult Dose for Hypertension:Metoprolol succinate extended release tablets:
Initial dose: 25 to 100 mg orally once a day
Maintenance dose: 100 to 400 mg orally once a day
-May increase dose at weekly, or longer, intervals.
-Doses above 400 mg per day have not been studied.
Usual Adult Dose for Angina Pectoris:
-Metoprolol succinate extended release tablets: 100 mg orally once a day
Maintenance dose: 100 to 400 mg per day.
Metoprolol succinate extended release tablets:
25 mg orally once a day (12.5 mg orally once a day in patients with more severe heart failure); double dose every 2 weeks to highest tolerated dose or up to 200 mg orally once a day
Usual Pediatric Dose for Hypertension:
Metoprolol succinate extended release tablets:
6 Years or Older:
Initial dose: 1 mg/kg orally once a day (not to exceed 50 mg orally once a day)
Maximum dose: 2 mg/kg (or 200 mg) orally once a day
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Toprol-XL?
Avoid driving or hazardous activity until you know how metoprolol succinate will affect you. Your reactions could be impaired.
Drinking alcohol can increase certain side effects of metoprolol succinate.
Toprol-XL side effects
Get emergency medical help if you have signs of an allergic reaction to Toprol-XL: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
very slow heartbeats;
a light-headed feeling, like you might pass out;
shortness of breath (even with mild exertion), swelling, rapid weight gain; or
cold feeling in your hands and feet.
Common Toprol-XL side effects may include:
dizziness, tired feeling;
depression, confusion, memory problems;
nightmares, trouble sleeping;
mild itching or rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Toprol-XL?
Tell your doctor about all your current medicines. Many drugs can interact with metoprolol succinate, especially:
any other heart or blood pressure medications;
This list is not complete and many other drugs may interact with metoprolol succinate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Toprol-XL only for the indication prescribed.
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More about Toprol-XL (metoprolol)
- Toprol-XL Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
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- Drug class: cardioselective beta blockers