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Methylphenidate and Nausea: What Users Say

Brand names: Concerta, Ritalin, Jornay PM, Ritalin LA, Daytrana, Quillivant XR, Metadate CD, QuilliChew ER, Cotempla XR-ODT, Aptensio XR, Relexxii, Methylin Methylin ER …show all brand names

Nausea: mentioned by 41 users (3.8%)

Based on user experiences from 1,082 Methylphenidate reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

loss of appetite 14.3%
anxiety 14.0%
depression 9.7%
insomnia 9.2%
headaches 6.7%
irritability 5.3%
mood swings 4.3%
weight loss 4.3%
anger 3.8%
nausea 3.8%

Reviews for Methylphenidate

Commonly mentioned side effects
  • mey...
  • Taken for less than 1 month
  • October 21, 2013

Methylphenidate for Depression "I've been diagnosed with ADD at the age of 42 and have struggled with major depression since adolescence. I currently take 10mg Methylin ER and 150mg bupropion XL in the morning. In the evenings, I take 50mg of trazodone for sleep. Three weeks now and I have never felt better. The adjustment period was pretty mild. Just a bit 'jazzed' in the morning and very mild nausea in the evening. This gradually faded over a week. My appetite is returning, my diet is improving and I am reconnecting socially. My sleep is good, and I awaken fully alert with the sunrise. I can't believe how dramatic this change is. I am optimistic that I will be able to dig myself out of the hole I've been in and re-build a life."

9 / 10
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148 Report
  • Can...
  • September 14, 2019

Methylphenidate for ADHD "Concerta is by far better than other ADHD meds, such as Adderall, in my experience. It is milder and much better at helping where it needs to and doesn't make me feel sick like Adderall did. I recommend this for all of you who have anxiety. Adderall made my anxiety worse on it. Concerta helped me feel less anxious because I have ADD and anxiety, this helped so much."

10 / 10
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52 Report
  • mis...
  • Taken for 2 to 5 years
  • June 5, 2014

For Depression "I was diagnosed with ADD (later amended to anxiety/depression) at university and went through the gamut of drugs (Ritalin, Dexedrine, Effexor, Paxil, Zoloft, Prozac) alone and combined. I hated the wait time for the meds to work and hated the wait time for the horrible side effects to wear off. I had nausea, insomnia, extreme weight loss, extreme sweating, and blurry vision to name a few. Later, a psychotherapist suggested Ritalin and clonazepam used together, and it changed my life. I could concentrate during the day and sleep at night. In Canada, I could only get a psychiatrist to prescribe this for me. Doctors wouldn't do it, warning of the possibilities of abuse, etc. Doctors here push the newer drugs, but I found these worked great!!"

9 / 10
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Frequently asked questions

  • Anonymous
  • Taken for 1 to 2 years
  • November 23, 2022

Methylphenidate for ADHD "Concerta may work for some people, but it actually screws up. (I’m a minor and can’t make myself talk to my parents - partially because of the drug). Although it has proven to “work” for me, this stupid drug makes me feel like a walking corpse. I feel usually numb throughout the day and have an emotional crash at home. I can never think of anything to say, I trail off in the middle of answering things. I have no appetite to the point at which the thought of food makes me feel nauseous. I randomly get extremely nervous, my insomnia has gotten worse, I have really shaky muscles, I have tics, I have increased symptoms of severe depression and social anxiety. When it wears off, I feel awful and mean, and if I skip a single day, then I feel really sick. I don’t recommend this drug."

1 / 10
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19 Report
  • pas...
  • Taken for 1 to 2 years
  • May 19, 2015

Methylphenidate for ADHD "I was diagnosed with ADHD when I was 7. And started taking Focalin soon after. I was very impulsive and couldn't focus. When I was 11, I started Adderall, which would keep me up at night. And I was dependent on it. Last year (13 years old), I was on 31 mg of Concerta. The first day I took it, I was lightheaded and nauseous. I am almost 14, and I take 27 mg of Concerta. It has helped immensely with social situations. I am now a 'cool' kid. I still struggle with school and am not very hungry. But overall, I think Concerta is a good fit for me. On an average day, I eat a small breakfast of toast and a fruit or vegetable, skip lunch (not ever hungry), and eat a light dinner. On the weekends, I don't take it, and I have the munchies all day."

8 / 10
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  • Hom...
  • Taken for 1 to 2 years
  • October 9, 2015

Methylphenidate for ADHD "At the age of 10, my son's ADHD was needing medical help. He was put on Concerta 18 mg and was a little unwell for two weeks, with a sick stomach, lack of appetite, and slightly listless. Made sure he ate breakfast before taking his tablet. He did look a little thin after about 1 year. We persevered with Concerta and life quickly improved until almost all ADHD problems had disappeared. Did not increase the initial drug dose. But after 18 months, he was becoming quiet and withdrawn. Decided to stop Concerta. Mild withdrawal symptoms for a week or so. We have never looked back. He is now 14, not on any medications and is a tall, healthy teenager. Wow, recommend this tablet. He may need it again someday."

10 / 10
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45 Report
  • Squ...
  • Taken for less than 1 month
  • December 17, 2014

Methylphenidate for ADHD "This is a great medicine. The first 2 days, I felt ill on it, nausea mainly, and I find sleeping incredibly difficult, but don't mind so much as I don't feel bad for it the next day. It's also making me dream a lot, but overall I feel great and have much more of a willpower to do everything. I started on 18 mg, and on Friday I go up to 36 mg to see how they go."

9 / 10
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37 Report

More FAQ

  • Mom...
  • January 23, 2010

Methylphenidate for ADHD "Oldest son (now 11 1/2) known to us (and teachers) to have ADHD by 5 years of age. Did not want him on medicines, but by 2nd grade, he was not able to work to his potential. Tried Focalin. Made my sweet, funny child nauseous and zombie-like. We both cried every morning while he took it. Tried for 2 months, said, 'forget it, not worth it.' Next 4 years - no medicines at all, just great teachers and a LOT of work to keep his grades/other issues with ADD on track as best we could. EXTREMELY difficult, especially for him to maintain/not stay stressed out at school/doing homework/projects/sports. Middle school began this year. Too much to handle without something. Began DAYTRANA-10 mg at Christmas. Works wonders for him! No side effects except less appetite!"

9 / 10
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  • Dwa...
  • October 11, 2016

Methylphenidate for ADHD "Was on Concerta XL for 7 days and had to come off it due to the unbearable side effects of the drug. I was diagnosed with ADHD (inattentive subtype), generalized anxiety, and depression. This drug made me feel very nauseous, gave me a headache, made me shake, gave me twitches throughout my body, messed my brain up in terms of cognition, etc., made me very aware of my heartbeat, made me extremely anxious to the point of not being able to leave my room or communicate with anyone and just generally messed me up. At one point, I was doing some stretching on a yoga mat to try and calm myself down, and I felt so confused that I didn't know what to do with my legs. This drug wasn't for me and caused an unpleasant experience."

1 / 10
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31 Report
  • Bru...
  • Taken for 5 to 10 years
  • March 17, 2015

Methylphenidate for ADHD "I was diagnosed in my late 40s with ADD. Dr. put me on Strattera, which was fine except for the severe nausea in the morning, even taking it with breakfast. Just could not deal with that, so was switched to Concerta. Loved it. No side effects. Could be off of it on the weekends and go back on it on Mondays with no issues. Dosage was 36 mg. About 5 years of taking it and perfectly happy. Switched insurance company and continued with my medication, then as of the first of the year will no longer cover Concerta. They want me to try all the cheaper formularies. Now I am struggling with all the other options they have provided and no success. Doesn't make sense!"

10 / 10
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30 Report
  • Sky...
  • Taken for less than 1 month
  • January 19, 2022

Methylphenidate for ADHD "Just got diagnosed with ADHD and prescribed Ritalin (10 mg 3 times a day, starting with 1 and increasing it every few days). It’s my 6th day taking it, and it feels like it’s doing the complete opposite of what it should be doing. It’s worsened my anxiety and depression, I feel robotic and numb, my moods fluctuate more than usual, I can’t focus, I feel tired and lethargic, irritable, nauseous, dizzy, racing heart, and none of my usual coping mechanisms that I had before I started meds are helping at all. It’s helped so little and made me feel so much worse. I've started dreading having to take them. I called my doctor today and am waiting for him to call back so I can speak to him about it."

1 / 10
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  • ap0...
  • Taken for less than 1 month
  • July 18, 2016

Methylphenidate for ADHD "I'm 17 and have been taking 18 mg Concerta every day for a week and a half. This is the second medication I've tried after being diagnosed with ADHD (I was also diagnosed with major depression). First, I tried Adderall, and while it made me feel very alert and productive, I could not handle the severe depressed feelings from the comedown. So far, Concerta has made me feel productive and positive for about 3 hours, and then depression slowly creeps in and gets progressively worse for about 8 more hours. It's not as intense as the depression from Adderall (which even led to suicidal thoughts), but it lasts longer. I also become irritable, anxious, and tired. I've also lost weight because trying to eat makes me feel queasy."

2 / 10
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24 Report
  • Anonymous
  • November 21, 2015

Methylphenidate for ADHD "Doctor started me on 27, took that for 3 weeks for severe ADHD, and it lost its effect, so I was put up to 54 mg and amazing changes. I get work done fast, and I am motivated. Only problem is the crash is pretty awful for me, I get really sick to the stomach and drowsy. For the sick stomach, I just use ginger, but drowsiness can't do anything."

8 / 10
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20 Report
  • Anonymous
  • April 7, 2008

Methylphenidate for ADHD "My doctor originally put me on Ritalin, and I stayed on it for 2 months. It made me very sick to my stomach, although it did improve my concentration. I have since switched to another medication and am doing much better."

4 / 10
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51 Report
  • zza...
  • December 20, 2017

Methylphenidate for ADHD "I'm 18 years old and just got prescribed Ritalin for ADD. The first day I was studying for 5 hours and then felt completely drained mentally. In general, I can do a lot more than before, but I feel like it's losing effect very quickly, as I can't feel it anymore, so I don't take it when I don't have to study (so I don't get too high of a tolerance). I started on 10 mg once a day, and after a week, I upped to 10 mg 3 times a day. I drink a lot of coffee, guarana, and stuff, so the effects are better. If I finish high school, it will be because of Ritalin."

8 / 10
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15 Report
  • Hon...
  • July 9, 2014

Methylphenidate for ADHD "Took 18 mg Concerta for 5 days. On day two, I woke up and cleaned and tidied the whole house, my partner thought something was wrong with me! Then the side effects came... nausea, depression, anxiety. By the time I was coming down at around 3 pm, I had to stay at home, I was unable to drive my car or even just go out. My doc wanted to try me on 5 mg Ritalin 3x a day quick release, but I refused. After reading the reviews on here about dexamphetamine, I started them this morning. 5 mg 3x a day. Hopefully, this will be the one for me."

4 / 10
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33 Report
  • Top...
  • Taken for 2 to 5 years
  • June 28, 2018

Methylphenidate for ADHD "Concerta works very well in the first years. Gradually, I started showing many signs they have here, headache, flu-like symptoms, I cannot sleep, outburst of excitement, changes in personality, nausea, and skin rash and skin splitting. I am going to change to another product that does not have all these symptoms."

8 / 10
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13 Report
  • Anonymous
  • Taken for 1 to 6 months
  • December 11, 2020

For Depression "Please note that the reviews here will mostly be from people that have had good results from this alternative treatment. It doesn't work for most, which is why it isn't FDA approved for depression. Buuuut, methylphenidate has made a difference for my depression. I do have suspected ADHD, but it hasn't been diagnosed. I've been depressed for ages, and I tried this. I have tried tons of antidepressants. I'm still on Prozac and Lamictal. Methylphenidate has made as big an impact as those two. It allows me to feel more connected, interested, calm, and stable. I take 5 mg three times a day, but I may increase. It sometimes gives me nausea, headaches, and fatigue, but the pros outweigh the cons (I do take the cheapest generic). If you've tried the more conventional treatments, give this a go. And who knows, if it works for you, maybe you should get tested for ADHD."

9 / 10
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13 Report
  • ali...
  • Taken for 1 to 6 months
  • December 19, 2017

Methylphenidate for ADHD "I started taking Ritalin recently, and it has already dramatically changed my life. I was diagnosed with nervous depression last year and prescribed Zoloft, which significantly drew me out of my depression. But Ritalin made me understand what it is like to be highly functioning. I cried after the first day I took it out of pure elation. I was able to stay awake at school the whole day (a huge personal rarity for me), and I stayed on topic and could hold conversations way easier after the first week. I stopped being so scatterbrained. My only complaint would be slight nausea and insomnia. I just wish it helped with my hyperspaces, as I am still jittery, but I am on a low dose."

9 / 10
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14 Report
  • Lau...
  • August 21, 2015

Methylphenidate for ADHD "I first started with 27 mg of Concerta. When it was giving me no effect, my doctor increased it to 54 mg. At first, I loved it. So great... motivation, energy, concentration, etc. But then I realized how bad my anxiety was getting and that my Prozac was no longer controlling my anxiety and depression. Concerta caused me to have very severe migraines, which caused nausea and dizziness. I would have a migraine in the morning, and the only thing that would take it away was the Concerta, and as soon as it wore off around 5-6 pm, there came the migraine again! I obviously couldn't take the Concerta or I'd be up all night. I am now switched to Vyvanse but haven't tried it yet. If Concerta did not cause migraines and anxiety, then I would really recommend it."

7 / 10
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19 Report
  • jus...
  • February 4, 2010

Methylphenidate for ADHD "For me, who is about to be 40 years old, I found that I had a shorter fuse than normal, couldn't finish anything, no energy, no focus. Went in to talk with a doctor, and he tested me and found that I too was ADHD. I cannot tell you that I was shocked. He said it was bad enough to warrant 36 mg starting point. I started it on a Thursday, and by Sunday I had lost 6 lbs already. Not that I didn't like losing that much, but not the way it happened. I have been so nauseated. Now, days are not too bad, but I feel like I am crashing at night and also very nauseated at night still. I cannot take this anymore. I will actually go back to the way I was before I will keep up with this. For my son at 81 mg a day. It is absolutely FANTASTIC for him."

7 / 10
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  • mom...
  • February 14, 2015

Methylphenidate for ADHD "My 11 yo has been on Concerta for 2 months. The first few days, he did experience some nausea, although it went away. After the first week, I could tell a huge difference in his attitude. He suddenly had a sense of humor, engaged in conversation without being distracted, and was bringing home/completing homework with no trouble! His grades have immensely improved! I can tell a difference (not huge) on the weekend days he doesn't take it. Or if he didn't sleep well the night before, and when it begins to wear off in the evening, he tends to be a little grouchy. The only other downside I've noticed so far is that he has lost approximately 4 lbs/month, which is concerning if it continues. So far, happy with the results!"

9 / 10
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  • tru...
  • Taken for 1 to 6 months
  • October 20, 2021

Methylphenidate for ADHD "18F. Mild side effects at the start (heart palpitations, nausea, reduced appetite), but slowly subsided. 18 mg felt like nothing, 27 mg boosted my physical alertness but did nothing for executive dysfunction, and 36 mg had really unpleasant side effects (anxiety, dizziness, jitters). Going to try an amphetamine-class drug next (probably Vyvanse), hopefully it'll be more effective."

1 / 10
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  • Nob...
  • Taken for less than 1 month
  • July 5, 2017

For Depression "I have bipolar disorder but mainly suffer with depressive episodes, which can last up to 7 months. I had high hopes for this drug as I am drug resistant now and have tried every antidepressant and mood stabilizer. I expected it to be a stimulant! I've only been on it 2 weeks, and my shrink says it needs 6 weeks to get into my system, but all my research points to a stimulant working within hours. I'm on 10 mg 3 x a day, and all it does is make me sleep! Not very stimulating! This dose seems to work for most people, maybe I need a bigger dose, but overall, so far I feel worse because I hardly have the energy to get out of bed, and I feel more stimulated by caffeine. Side effects for me were intense headaches and nausea, lack of appetite."

1 / 10
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  • Ali...
  • Taken for less than 1 month
  • December 18, 2021

Methylphenidate for ADHD "I am a 22-year-old female. I was recently diagnosed with ADHD after discussing my struggles with a counselor and was recommended to speak to my physician about getting a diagnosis. I have been on 18 mg for almost 2 weeks. I noticed a change right from the start. It feels like there is more time in the day, I am more productive, less procrastination, don't feel like staying in bed all day anymore due to being overwhelmed. I also feel more level-headed and haven't snapped at my family. However! I am getting side effects that make me wonder if it is worth it. Some of the side effects I have are nausea, headache, and overall just not feeling great. Kind of like something is 'off' with me. I also notice becoming more emotional in the evening as the medication leaves my system, but not unbearable. The weird thing is, I mostly feel side effects on slow days, and no side effects on days that I have a lot on my mind/lot's to do."

7 / 10
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