Xyzal and Fatigue: What Users Say

• Let...
• Taken for 1 to 6 months
• February 16, 2020

For Allergies "I started taking Xyzal about 2 months ago. For the first week all was well. It helped with my allergies and stuffy nose. After that, I noticed my urine turned orange. I thought it was the effect of an antibiotic I was taking, so the doctor told me to stop taking the antibiotic. Urine still remained dark after that. Then a cough began that I have had for at least 3 weeks. The final straw was when my face started breaking out with a rash and then my leg. I never thought the medication was the cause of all this until I read reviews from others. I have experienced the depression, the cough, the rash, the dark urine, the fatigue, so now I'm going to stop taking it and hope I can clear up all of these issues. I would say don't take this drug. It's just not worth the risk of all of the side effects."

• Tmi...
• Taken for less than 1 month
• December 13, 2019

For Allergies "My allergies were bad, so I took this medication - Xyzal - for 2 weeks and started to feel depressed. I thought it could be due to the fatigue I was experiencing, however, after reading a few other reviews, I see that depression is very possibly a result of the use of this medication."

• Mel...
• Taken for 1 to 6 months
• July 1, 2019

For Allergies "For the last few months, I have been experiencing horrible GI issues. Pain and pressure in the top center of my abdomen, bloating, fullness, no appetite, nausea, even joint pain and fatigue. I was thinking the worst, that I had developed some chronic condition and was going to be miserable forever. I had tried taking probiotics, acid reducers, gas relief, etc., and nothing was working. Then I remembered I had started taking Xyzal about the time this started. I was taking half a pill at night, every night since February. I have stopped, and all my symptoms went away. I can finally eat food and not want to die afterward. Super effective for my allergies, but I would rather have a runny nose than go through what I have been."

• Cmg...
• Taken for less than 1 month
• June 16, 2019

For Allergies "Bought the Xyzal yesterday morning as I had run out of my other allergy medication. Took ONE pill at 8 a.m. and was out cold and on the couch for the rest of the day. I am experiencing a loss of balance and can manage to stand up for a minute before I get really hot and nauseous. It's now been a little over 24 hours, I'm still on the couch, no balance, and feeling really fatigued. Will NOT take this again."

• Mel...
• Taken for 1 to 6 months
• September 9, 2018

For Allergies "I am so careful about meds and always I am cautious about side effects. I am feeling really stupid right now. I gave this a try as nothing else really has helped me with my severe allergies. It was amazing from the start, and I have had almost total relief. I take it daily, every morning, to stop the inevitable from starting. I wish I had looked into the side effects long ago. After 6 months of completely debilitating exhaustion, fatigue, mood swings, and daily diarrhea, I now realize my problem. I have been checked out head to toe by a doctor, blood work done, and we were left with no answers until now. I guess miserable allergies, sneezing, and coughing are my trade-off. Is there nothing put out by big pharma that won't cause more problems and anal leakage? I'm serious, this sucks."

• utg...
• Taken for less than 1 month
• October 28, 2017

For Allergies "The reviews are true!!! I normally take 12-hour Allegra-D (as needed). When I took this, I immediately felt worse, my nose wouldn't stop running, I got very hot (red), and I was coughing almost like it made it worse. I felt it kick in and got extremely heavy. My nose felt like I was at the bottom of a pool, swollen, my eyes were puffy, my vision was impaired, I had horrible nightmares, and I barely woke up when my alarm went off. I felt worse than when I went to bed!!! Fatigued all day, bloated, headaches, swollen nose, and massive sinus pressure when I looked down at work. It felt like my senses were numb and I wasn't human. Everything everyone listed negative is true. I will NEVER take it again, and I'm shocked it's still available OTC. Do NOT waste your money, it's total fraud."

• Anonymous
• Taken for less than 1 month
• June 26, 2017

For Allergies "I feel absolutely horrible. I ran out of Zyrtec, my son takes this, so I figured I'd try it. On day two, I feel a combination of having a concussion and a hangover all at one time. I'm fatigued, dizzy, and have a headache. This does not include the pressure I feel in my sinuses. I feel absolutely horrible. I'm done, I won't take this again. I'm honestly not even sure the FDA should have approved this drug."

• Mon...
• Taken for less than 1 month
• July 24, 2021

For Allergic Rhinitis "This drug made me completely crazy. I started having bad anxiety, then anger and depression. Very bad depression. Horrible headache and fatigue. I lashed out at a coworker and got in trouble. What a disaster. Never again. Going back to Zyrtec."

• Anonymous
• July 17, 2017

For Allergic Rhinitis "Took this at night while waiting on an Allegra order. It was not terribly effective on my indoor/outdoor allergies. I felt marginally less wheezy at night, but my nose was stuffed and eyes itchy the next morning. On top of that, it makes me sluggish and stupid for a solid 24 hours. Forget drinking on this pill; the alcohol will go straight to your head. Granted, the label says all of this, but these itty-bitty pills aren't effective enough to be worth it."

• Ker...
• December 30, 2008

For Allergic Rhinitis "Incredible results. I have recently developed horrible fall allergies with the whole - sneezing, runny/stuffy nose, watery/itchy eyes, cough, fatigue, and everything else. I would need a new tissue every 5 minutes. I took one Xyzal at 5 PM on Tuesday, and it cleared every single thing up. It didn't begin to fade until 12 AM on Wednesday. I absolutely love this little pill."

• QMC...
• Taken for less than 1 month
• July 13, 2017

For Allergies "My doctor suggested this medication for allergies a few days ago. I was taking it for two days, and I was completely exhausted and wiped out both days (which never happens to me). So I decided to research it and saw that many people had a similar reaction. This was a significant reaction, so be careful before you take it. I have now stopped."

• Tra...
• Taken for less than 1 month
• May 31, 2017

For Allergies "Bad experience for me. First side effect was tired. Turned into totally wiped out. Lack of energy, feeling sore, then the sore throat! This drug kicked my butt. It's not for me, I want to be outside active. This drug will keep you on your sofa. I'm going back to my old faithful. I tried this because of the coupons."

• Con...
• Taken for less than 1 month
• August 14, 2019

For Allergies "Xyzal was prescribed for my daughter by her allergist for abdominal pain and bloating, with hives and an itchy mouth after certain foods. Symptoms getting worse over 5 years. Started whole tablet for 3 nights before cutting it in half due to severe drowsiness and slow response time. Ugh. She weighs 105 lb and is 22 years old. She currently complains of being horribly fatigued all day after 12 hours of sleep. Senior year in college begins next week. Bloating is still occurring, as is abdominal pain."

• Mel...
• September 28, 2017

For Allergies "Will not take again! Up all night, frequent urination. Finally fell asleep and woke with awful migraine, dizziness, nausea, fatigue, and muscle pain! I've been feeling awful all day! Can't wait to get this out of my system! Will go back to Claritin, which I tolerate. Ughhhh..."

• Anonymous
• March 25, 2022

For Allergies "Have been taking it for 2 weeks for seasonal allergies, and I have had no itchy or watery eyes like I typically do this time of year, but…the side effects! Extreme fatigue, almost to a depressed state, already gained 3 pounds in 2 weeks, and have random acne all of a sudden. Definitely stopping this medication."

• New...
• January 24, 2023

For Allergic Rhinitis "I have been taking Xyzal in combination with Singulair, and I have been feeling very fatigued and sleeping for hours. I have had to miss work because I couldn't drag myself out of bed and was hesitant to drive. I tried taking it earlier in the day, but no better results. This doesn't work for me, and the side effects are worse than the illness, but it may work for others."

• Pra...
• Taken for 1 to 6 months
• May 30, 2022

For Allergies "I took Xyzal for a couple of months, stopped and restarted this spring. Since restarting, I was getting more fatigued and achy, little by little, with almost a drugged/hungover feeling most every morning. It would take me until late afternoon to feel somewhat functional. I chalked this up to other issues (hormonal, life changes, work stress), but then stumbled upon something that discussed such side effects with allergy medicines. After doing extensive research, I've found these effects are not as uncommon, or random, as they first appeared. After stopping about two weeks ago, I don't have the exhaustion, body/joint pain, and drugged feeling every morning. It has been a marked, and remarkable, difference. Granted, I still have allergies...but I'll gladly take those over feeling like I was 137 years old. I was getting afraid that something else was happening or that if this was just 'aging,' I wasn't going to make it much longer! I'm feeling much better now this medicine is out of my system."

• DBa...
• Taken for 1 to 6 months
• March 12, 2018

For Allergies "I started taking this medication less than a month ago for seasonal allergies since my daily Zyrtec was not effective. I took the first dose before bed, and it was great at helping me sleep better, and I felt great the next day; symptoms weren't 100% gone but much better. Then, after a few weeks, the effect wasn't as great as Zyrtec (when it worked), and then came the side effects. Despite giving relief and improvement to already good sleep in the beginning, a month in, my allergies have gotten worse. I have possible side effects (grogginess all day, lack of appetite, malaise, scratchy throat, and fatigue). Heading to the second doctor visit today and not continuing this medication considering this is the only medication I am on, and despite having allergies, I felt far better before being on it."

• DBa...
• Taken for 1 to 6 months
• March 12, 2018

For Allergies "I started taking this medication less than a month ago for seasonal allergies since my daily Zyrtec was not effective. I took the first dose before bed, and it was great at helping me sleep better, and I felt great the next day; symptoms weren't 100% gone but much better. Then, after a few weeks, the effect wasn't as great as Zyrtec (when it worked), and then came the side effects. Despite giving relief and improvement to already good sleep in the beginning, a month in, my allergies have gotten worse. I have possible side effects (grogginess all day, lack of appetite, malaise, scratchy throat, and fatigue). Heading to the second doctor visit today and not continuing this medication considering this is the only medication I am on, and despite having allergies, I felt far better before being on it."