Leuprolide for Prostate Cancer User Reviews (Page 5)

• Ano...
• Taken for 5 to 10 years
• May 24, 2025

Leuprolide "I have been treated with Lupron Depot for seven years now for my prostate cancer, along with radiation, Taxotere infusions, and apalutamide. After reading the list of side effects, I now understand that my problems with memory loss, irritability, lack of energy, and trouble sleeping were due to this medication. My cancer remains but is not progressing, and my oncologist is happy with my progress and blood work."

• Mr ...
• January 23, 2016

"I had prostate cancer that had metastasized and was given the 3-month leuprolide shot along with Casodex; within 24-48 hours, I had horrible side effects: memory loss, couldn't walk or even stand up, dizziness, weakness. Three days later, I was taken to the ER and had blood clots in my lung. I do not recommend the leuprolide and Casodex combination. Not sure which one is worse, but I would give it a -1 rating if available."

• Ano...
• Taken for 1 to 2 years
• May 19, 2025

Leuprolide "I've been taking it for over a year and noticed a pronounced sadness and depression that wasn't there before. I am an adult male. I also have weight gain even though I exercise. I have to force myself to do things. My PSA and testosterone have come down to almost zero."

• Mar...
• Taken for 6 months to 1 year
• March 1, 2025

Leuprolide "Have been getting 3-month injections of this for 4 cycles. Also had Docetaxel and Nubeqa. Apart from low energy, I have had no side effects from any of these drugs. I mean nothing. Low and lowering testosterone and PSA. I do not expect prostate cancer treatment to leave my sexual function unchanged. I am nearly 79 years of age. Eligard seems to be working and is causing me no ill issues."

• Bil...
• Taken for 6 months to 1 year
• November 30, 2024

Leuprolide "I was diagnosed with high-risk prostate cancer. I opted for complete removal of the prostate and follow-up treatment of ADT and radiation treatment. My first injection was June 2023, and the second was January 2024. PSA test every three months since the first injection, and PSA was 0.00. I experienced many of the normal side effects from the Lupron injections, the worst has been the fatigue, joint pain, sweats, and hot flashes. It has been almost a year since my last injection. I still have some lingering side effects, with the worst and most often the sweats and hot flashes."

• Bri...
• Taken for 1 to 6 months
• November 5, 2024

"The most common side effect (several times per day) is hot flashes. Also, depression and anxiety, especially at night. I am on the 6-month interval for prostate cancer. I have also experienced loss of muscle mass and increased belly fat but have been able to counter these side effects with increased exercise, especially weight lifting. My testicles have shrunk noticeably and my desire for sex has dramatically decreased, although not entirely. I am able to attain an erection with medication but not fully and not long-lasting. I use Sildenafil."

• Rob...
• Taken for 1 to 2 years
• November 20, 2024

Leuprolide "Prostate normal at last checkup. Dosing sequence: 1 month, 3 months, 6 months x 3. Experiencing joint pain in shoulders, hips, knees, and periodic sharp pains in the head and neck area. Random stabbing pains in the left thigh and feet as if being jabbed with a large needle. Moderate to severe swelling in the feet and lower legs. Frequent hot flashes. Frequent intestinal issues. Frequent need to urinate. Extreme fatigue. Irritability."

• Bru...
• Taken for 1 to 6 months
• December 26, 2024

Leuprolide "I am taking this drug along with 10 mg of Prednisone, so some of my symptoms may be from either drug. I've been taking Lupron Depot for four months and the prednisone for eight months. Hot flashes, 15-20 per day. Lasting 3-4 minutes. Dizziness, but much better since I stopped taking Flomax. Weight gain, always hungry. Prednisone does this to me. Fainting, may be dehydrated at times. A bit of chest pain, but not serious."

• Mik...
• Taken for 1 to 2 years
• January 13, 2025

Leuprolide "Overwhelming, suffocating hot flashes that cause instant full-body sweating. This has caused disruption to all aspects of each day (whether at work, at leisure time, or bedtime). This drug causes weight gain regardless of exercise intensity. It has completely stopped all sex drive or interest. It has caused genital shrinkage and, at times, discomfort. I have unusual fatigue and muscle atrophy. I have been getting the drug for a year and a half. I will not be able to tolerate any more of this drug. It has kept my testosterone level at near undetectable levels."

• jam...
• Taken for 1 to 6 months
• January 19, 2025

Leuprolide "Weakness, itching skin, high blood pressure, increased A1C and glucose levels, diminished platelet level and red blood cells. It has reduced my PSA from 7.8 to 1.6. Have taken additional drugs to reduce blood pressure, another to help with urinary incontinence, and antihistamine for itching skin."

• Tim...
• Taken for 6 months to 1 year
• February 9, 2025

Leuprolide "1 year on Lupron 3-month shots after I had prostate removed with 1 spot of cancer spreading to hip 5 months after removal. 3 hits of radiation cleared spot. PSA undetectable for 1 year now with hot flashes only side effect, but now knee and ankle ligament sensitivity like hitting the funny bone... little numbness starting in the same areas. I'm considering a vacation until a PSA rise? Risky but don't want more damage in legs and hope it will reverse some? Been taking fenbendazole, Joe Tippins Protocol, over the same year. Good luck to all during your life's journey and see ya on the other side ✨️"

• Car...
• Taken for 1 to 2 years
• October 15, 2024

Leuprolide "I have been on Lupron for 16 (of scheduled 18 months) to help suppress the return of prostate cancer. So far, the cancer is resolved. The side effects for me have been tiredness, mild depression, leg weakness and mild leg pain, mental fog, weakened memory, diminished thought clarity, significant muscle reduction, and lack of energy. Also, occasional diarrhea. Use was probably effective as cancer has not returned."

• Bro...
• Taken for 1 to 2 years
• August 30, 2024

Leuprolide "I can sure relate to all of these Eligard reviews. She 70, diagnosed about 20 months ago. I don't recall Gleason numbers, PSA was 5.7. I had 28 radiation treatments and started Eligard. Just had the 4th shot and last. Miserable side effects. Body aches, endless peeing, shrunken penis, heart flutter, left arm pain on occasion, massive hot flashes, light-headed. Good part? PSA at .0004."

• Mar...
• Taken for 1 to 6 months
• November 22, 2023

Leuprolide "65-year-old who had a Prostectomy in Dec 2022. Psa was still elevated after surgery. PET scan revealed PC in pelvic lymph nodes. Prescribed salvage radiation and ADT. On med for 5 months now (2 three-month 22.5 injections). PSA was undetectable at the time of the 2nd injection. So I guess it works, or was it the 37 radiation treatments I received in Jun/July. Won't know unless I discontinue Lupron. As for side effects, they have been somewhat minimal. Libido gone. Loss of pubic hair but returning, a decrease in the size of the penis but returning, weight gain of 5-8 pounds. Hot flashes, but they have decreased significantly (I take Vitamin E). I have joint pain, especially in hands, but I am hoping Vitamin D will help. Sleep is getting much better. My mood has been very good. I exercise frequently, eat healthy, and have no stress. I think that helps a lot. I think I will continue with injections. The doc wants to do 2 years of injections. Overall, not too bad."

• Sco...
• Taken for 6 months to 1 year
• May 17, 2023

Leuprolide "Diagnosed with prostate cancer with a Gleason 7, PSA 8.2. Received a 6-month Lupron shot on Nov 15, 2022, and 20 sessions of radiation starting Jan. 18, 2023. I have suffered hot flashes several times a day and night, and they have become more intense in the last 6 weeks, by that, I mean I get completely soaked several times a day and night. I have gained around 20 pounds, have a loss of muscle strength, neuropathy in my hands, bone pains in my feet, back pain, mood swings, and lack of motivation to get moving. I do ride my bicycle several times a week, about 100-plus miles, and this is how I keep my sanity. Last appointment with the doctor was on May 15."

• Chu...
• Taken for 6 months to 1 year
• May 19, 2023

Leuprolide "76YO. Got Bicalutamide pills and a Lupron shot twice before my 'High Intensity Focused Ultrasound (HIFU)' operation to kill my prostate in 2019. Fatigue was my worst side effect. Did serious and intense Max Gerson Cancer Protocol therapy for three years. Totally off alcohol and mostly vegetarian. Mostly no carbs. Lost twenty pounds. When PSA started creeping up, my urologist put me on strictly Bicalutamide pills once a day (50mg). Negligible PSA for almost two years until tender breast and some enlargement took me off it. Been off for six months and back to normal in every way, including testosterone. PSA is creeping up again, and I think I will go back to the pills but only once or twice a week and see how my PSA does. I get the PSA checked every other month. I feel very good."

• fat...
• Taken for 1 to 6 months
• June 1, 2023

Leuprolide "Tried Lupron Depot every 3 months two times, but severe fatigue, occasional dizziness, and passed out. Side effects were not acceptable to me. Orgovyx + Xtandi is much better. Although, without testosterone: fatigue, no erection, lack of enthusiasm, and weight gain."

• Bay...
• August 27, 2017

"Had a radical prostatectomy in 2009. Discovered to have spread to the spine in 2017 and was told I would be on Lupron till 'the end.' For me, the most telling effect apart from weight gain and hair loss (chest) has been the incredible emotional rollercoaster I have been on! What is especially striking is the fact that memories from 25 years ago and the split from my first wife seem more 'real' to me now than my current state! The pain of those old memories and regrets is exceedingly intense! Very strange!!! In fact, those old emotions became so powerful I sought out a psychiatrist to help me cope. Lorazepam has proven to be a godsend!"

• Yoo...
• Taken for 6 months to 1 year
• December 2, 2024

Leuprolide "The worst effect (in combination with Zytega and prednisone) is numbness of the feet and ankles, and intense tingling of legs. Both effects make sleeping nearly impossible. Also, weakness, muscle and joint pain, and atrophy of testicles. I take two Zytega tablets and one prednisone tablet daily. My PSA is consistently less than 0.04, which I believe is the detection limit. I have been taking these meds for 9 months post-surgery and radiation."

• Ric...
• Taken for 1 to 6 months
• November 8, 2024

Leuprolide "Some hot flashes for short periods when thinking hard and only for maybe 2 or 3 minutes. Zero sex drive. Maybe joint pain. Maybe less energy. PSA at 0.25 after 3 or 4 months. There is some merit in not wanting to have sex often for that has been cured."

• sta...
• Taken for 1 to 2 years
• March 10, 2026

Leuprolide "I'm sure it helped, however, the night sweats, pain in the legs, chest tightness, among other side effects, including loss of testosterone, resulting in erectile dysfunction. I have decided that I will not take it again if my cancer worsens."

• Ano...
• Taken for 1 to 6 months
• June 2, 2026

Leuprolide "Well, if you have stage 4 prostate cancer, it is effective in arresting the spread, but it comes with a high price. It has chemically castrated me, I have severe pain in my joints and pain in my arms and legs. Fatigue, weakness, total lack of energy."

• Nie...
• Taken for 6 months to 1 year
• July 2, 2026

Leuprolide "I don’t like the hot flashes accompanied by profuse sweating, lack of energy, and weight gain. One would think that the pharmaceutical industry would have found something better during the 32 yrs Lupron D has been the primary drug to treat prostate cancer."

• any...
• Taken for 2 to 5 years
• December 2, 2024

Leuprolide "I have been on Lupron for 20 months now, and it reduced my PSA from .64 to undetectable. The side effects for me have been hot flashes a couple of times a day, loss of body hair, 20 pounds of weight gain, and complete loss of my sexual function and appetite. I will be going off Lupron when this shot wears off in a couple of months. I have been receiving the 6-month shot. I am 67 years old and have high-risk prostate cancer, have had my prostate removed, and went through 38 rounds of radiation. I feel I am doing as well as can be expected and do everything I like to do minus my libido. Good luck to all!"

• Ric...
• Taken for 1 to 2 years
• September 19, 2026

Leuprolide "This medication along with my daily Erleada medication has reduced my PSA numbers to 0.03 for the last 2 years. Surgery (2020) to remove the prostate and 60 days of external radiation (2021-2022) did not keep the PSA numbers down."