Anafranil and Depression: What Users Say

• mar...
• Taken for 6 months to 1 year
• June 14, 2017

For Obsessive Compulsive Disorder "After a long 12 years of being on Effexor XR, my anxiety OCD was beginning to get worse. My GP felt it necessary to increase my Effexor to 150 mg, and although I had done that in the past, Effexor was just not working anymore and actually began working against me. Awful anxiety at nighttime and my OCD ('I have pure-O'), and I felt I couldn't get things under control. I had enough, and it was time for a change. I saw a different GP who was knowledgeable about anxiety, and he switched me to clomipramine/Anafranil 50 mg to start. I only had a few bad days from the initial switch because Effexor can be nasty to come off, but then my life came back, and I feel great! Just remember nothing will rid you of OCD, but this med is great to manage it!"

• BeF...
• Taken for 1 to 6 months
• August 8, 2020

For Obsessive Compulsive Disorder "I took Anafranil for 5 months at a dose of 25 mgs. Definitely took some power away from the intrusive thoughts, but not fully. Had a hard time with being tired in the morning, terrible dreams, mild constipation. On a positive note, I did not gain any weight and was able to work out regularly. Tried to go up to 50 mg, but that got rid of my libido. Felt like taking an upper and downer at the same time. Some of the time, I felt good, other times, I felt depressed. Unfortunately, couldn’t tolerate a higher dose. But if you really need to shut off the noise, this may be the way to go. Best of luck."

• Inf...
• Taken for 1 to 6 months
• July 30, 2022

For Obsessive Compulsive Disorder "My experience with Anafranil over the past 3 months is as follows: severely chronic constipation, urinary retention that hospitalized me the other day, a 60 percent increase in my depression, a 90 percent increase in my overall anxiety, and at best a 15 percent decrease in my OCD symptoms. Not to mention the sexual dysfunction that includes painful orgasms and low libido, and then there's the constant dry mouth. I cannot for the life of me recommend this medication to anyone. I'm currently 5 days away from discontinuing this medication and replacing it with Prozac."