Chlorpheniramine / hydrocodone User Reviews & Ratings (Page 4)
Brand names: Tussionex Pennkinetic, Hydrocodone GF, TussiCaps, HyTan
Chlorpheniramine / hydrocodone has an average rating of 9.2 out of 10 from a total of 133 reviews on Drugs.com. 91% of reviewers reported a positive experience, while 3% reported a negative experience.
Reviews for Chlorpheniramine / hydrocodone
- pup...
- Taken for less than 1 month
- May 7, 2022
Chlorpheniramine / hydrocodone for Cough "I had incessant coughing due to post-nasal drip, which none of the OTC meds made a dent in. Saw my ENT doc who did endoscopy and, not surprisingly, found heavy sinus and throat mucus. He prescribed Tussionex-P and Prednisone. The Tussionex knocked the cough right out, enabling me to sleep and recover my voice. It is annoying that it's so hard to find; the first four pharmacies I went to didn't carry it. For me, it's a wonder drug. It succeeded where all the others failed, and I haven't had any side effects. If I could, I would give it a rating of 11."
- stu...
- February 11, 2009
For Cold Symptoms "This is the only medicine I have found that clears up my stuffy/runny nose, sneezing, itchy, watery eyes. I've tried several allergy pills and nasal sprays with no relief! The only problem is, doctors don't want to prescribe this medication because so many patients abuse it. I've also taken this medicine for bronchitis, and it worked wonders!"
- Ace...
- June 29, 2008
Chlorpheniramine / hydrocodone for Cough "Cleared my cough and allowed me to rest. This liquid must be taken exactly as prescribed. I experienced a slight feeling of lethargy the next day. Given that as a side effect, I would take this again for any of my severe coughing spells."
- Rem...
- March 24, 2010
For Cough "Agree with all that was said. It works in 20 minutes and lasts 12 hours. I do get itchy, a little restless, but the cough is gone. My insurance does not cover any part of it, and $100 is steep but worth it."
- Jur...
- October 11, 2009
Chlorpheniramine / hydrocodone for Cough "This medicine worked very well for me. I had a bad cough that was keeping me up night after night. This allowed me to sleep and totally stopped the cough. I couldn't take it during the day without being groggy, however, I would caution against this, although the recommended dose said every 12 hours."
- Anonymous
- April 6, 2009
Chlorpheniramine / hydrocodone for Cough "Obstetrician prescribed this to me due to a chest infection/head cold that resulted in no sleep for me. It totally knocked me out - I slept better than I had during my entire pregnancy. Great part is I still have plenty of fetal movement."
- fib...
- April 20, 2009
"Hope this will help someone who is concerned about Tussionex. I have taken it for 15 years off and on for allergy cough or bronchitis. It is AMAZING. I have, over the last 4 years, developed fibromyalgia. Doctors tried every kind of drug for fibromyalgia. I stopped taking all of them for fear of liver and kidney damage. Now all I take is Tussionex on the days that I feel really bad. I don't take it daily. I guess you could, but please ask your doctor about any other medicines you might be taking or about the long-term side effects. NEVER go solely by what someone says on here. I just wanted to tell you what it does for me. Fibromyalgia is a weird illness, and after years of pain and losing days from sleeping, you will do anything to get your life back."
- Anonymous
- April 26, 2008
Chlorpheniramine / hydrocodone for Cough "This medication was great to reduce coughing and to sleep well at night after a few sleepless nights before the med. But I developed very bad constipation after a few nights (I took it only once a day, before bedtime), which was so bad that I would never use this medication again."
- Anonymous
- May 12, 2009
Chlorpheniramine / hydrocodone for Cough "This stuff is great. I have had a chronic cough for over a year following an esophagectomy. This is the first medication that actually works for more than a couple of hours. I can actually make it through the night without having a coughing episode. As a side benefit, it tastes pretty good."
- Anonymous
- February 18, 2009
For Cough "Had I known there was a drug that provided this much relief, I would've gone to the doctor days ago. It's amazing how immediately effective it was. Never had luck with cough syrups until this one. Two thumbs up for sure."
- Per...
- Taken for less than 1 month
- August 4, 2025
Chlorpheniramine / hydrocodone for Cough "This is the best cough medication made for severe cough or severe cough with cold/flu symptoms. It diminishes the coughing so it’s bearable and you can sleep without coughing so hard you feel like you’re going to throw up. Another thing I like about Tussionex is that it’s time-released. Whether you’re taking the pills or the syrup, it’s only taken every 12 hours and it actually lasts! So you can get good rest. I’m usually out of work at home really sick if I’m taking Tussionex, but I can function on it as well if necessary. I say this as someone who takes opioid pain medication daily as prescribed and is opioid tolerant, it still works and helps a severe cough so much. Tussionex works wonders for its intended purposes. The Hydrocodone Polistrex 5 mg is equivalent to 10 mg Hydrocodone Bitartrate (the kind found in Vicodin, Lortab, and Norco). Also, it tastes great, unlike most cough medicines."
- yum...
- October 29, 2009
Chlorpheniramine / hydrocodone for Cold Symptoms "I was prescribed this medicine after going to urgent care for what I thought was a basic head cold. I was told I had the flu. I did not think my symptoms were consistent with what I considered the flu, but I had not been sick in a long time and cannot remember when I last had the flu. The medicine definitely dried me up, per se, but I started getting really jittery and anxious, and when trying to go to sleep, could not due to the itching. I know I am sensitive to medications and have never had this medicine before. If you are like me and sensitive to medicines, be prepared for side effects."
- Lin...
- Taken for less than 1 month
- March 30, 2021
For Cough "This stuff is amazing. No other cough syrup, prescription or OTC helps me. One year I couldn’t get rid of a cough for about 2 months and tried everything. My Dr. decided to give this a go, and the first night taking it almost immediately took my cough away. This is all I ever ask for now if I get a bad cough!"
- Anonymous
- June 11, 2009
Chlorpheniramine / hydrocodone for Cough "I have had a bad cough for over a week. The doctor said it was bronchitis and prescribed this and Septra. It does dry you up and quiets the cough. I've taken this before but don't remember it making me feel so loopy, even 12 hours later. Definitely don't drive, and it would be advisable to have someone around."
- Sjo...
- Taken for 10 years or more
- February 26, 2025
Chlorpheniramine / hydrocodone for Cough "I've struggled with a chronic cough for years. Even the slightest trigger—a mild cold, seasonal allergies, or any minor irritant—can set off a relentless, self-perpetuating cough that lasts for months. I’ve tried everything, but this is the only remedy that truly works. I take it at night, usually just half the dose, and while it still takes a few weeks, it effectively calms my cough enough to function and finally heal from the irritation. I honestly don’t know what I’d do without it."
- ano...
- Taken for less than 1 month
- November 17, 2023
For Cough "This is pure magic. I had a cough for a week that was so constant and paroxysmal that I pulled muscles in my chest and abdomen, and was seriously afraid of having a stroke. OTC did nothing, benzonatate and promethazine DM did nothing. Less than 2 hours after the first dose of this medication, I began to see improvement. After the third dose, the cough was gone for 10 hours. The downside is that when it stops working, it's sudden and harsh. It doesn't last as long as you are supposed to wait between doses, and I wake up with a headache. But I'll gladly pay that price for relief of coughing."
- Anonymous
- March 7, 2009
For Cough "This medicine really helped my cough, but it made me itchy, and I got hives on my elbows and knees. It also made me very tired the next day, but tiredness alone wouldn't stop me from taking it again. It did wonders for my cough."
- Ano...
- Taken for less than 1 month
- January 9, 2020
For Cough "I am allergic to most cough medications, so my doctor prescribed me the liquid version of this after having no luck with the Tessalon Perles. I took the dosage prescribed at approximately 8:00 p.m., and it made me extremely drowsy within half an hour. I slept really well and didn't cough all night, but it made it almost impossible to get out of bed this morning. It's 11 a.m., and I still feel very out of it. Overall, this medication does what it's supposed to, but I am going to have to take it much earlier in the evening to see if it makes a difference the next morning. I would not be able to take this medication during the day."
- Lon...
- August 1, 2015
For Cough "This stuff is scary. It gives me night sweats, but more concerning, I get really high levels of anxiety, and I am concerned about my breathing. Feels too relaxed, like breathing may stop. Horrific feeling. Result is massive insomnia, and I still cough."
- Fuf...
- Taken for less than 1 month
- January 21, 2020
Chlorpheniramine / hydrocodone for Cold Symptoms "Unfortunately, I have had the third teaspoon, and I am still coughing my butt off. I know for a fact that Walgreens at the University and trying are good for not giving you the prescription prescribed by your attending physician. I am definitely returning this medication to Walgreens, so help me God."
- Ano...
- Taken for less than 1 month
- February 14, 2014
Chlorpheniramine / hydrocodone for Cough "I have had a terrible cold with cough and breathing issues, especially at night. This prescription was great for the cough and ability to get some rest."
- tri...
- March 5, 2013
Chlorpheniramine / hydrocodone for Cough "It was like a miracle. Instantly stopped coughing and slept all night without waking up coughing. Taste is like frosting."
- bee...
- Taken for less than 1 month
- February 5, 2013
Chlorpheniramine / hydrocodone for Cold Symptoms "This is the best cough and cold syrup ever made. Unfortunately, I am a smoker, so I tend to get coughs and colds easier than non-smokers. This really works for me, and it makes me feel better."
- Bug...
- Taken for less than 1 month
- April 7, 2017
Chlorpheniramine / hydrocodone for Cough "Only thing that helps a cough so bad you are throwing up."
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More about chlorpheniramine / hydrocodone
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- Drug class: upper respiratory combinations
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Patient resources
- Chlorpheniramine and hydrocodone drug information
- Hydrocodone and chlorpheniramine (Advanced Reading)
- Hydrocodone and chlorpheniramine polistirex (Advanced Reading)
Other brands
Tussionex Pennkinetic, TussiCaps, Vituz
Professional resources
- Hydrocodone Polistirex and Chlorpheniramine Polistirex Suspension prescribing information
- Hydrocodone and Chlorpheniramine (FDA)
- Hydrocodone and Chlorpheniramine Solution (FDA)
Chlorpheniramine / hydrocodone for Cough "I have suffered from chronic lung infections and bronchitis for a number of years. I have tried multiple medications in the past and nothing has worked. My doctor prescribed Tussionex Pennkinetic, and it is fantastic. I would rate this medication a 12 out of 10 if I could. Be sure to hydrate well while taking this medication. The drowsiness that I experience helps me sleep, and I am cough-free all night long. The 12-hour window of effectiveness makes this the best treatment for a chronic cough."