hydrocodone and chlorpheniramine polistirex (Oral route)
klor-fen-IR-a-meen pol-ee-STYE-rex, hye-droe-KOE-done pol-ee-STYE-rex
Concomitant use of opioids with benzodiazepine or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Avoid use of opioid cough medications in patients taking benzodiazepines, other CNS depressants, or alcohol
Commonly used brand name(s)
In the U.S.
- Tussionex Pennkinetic
Available Dosage Forms:
- Capsule, Extended Release
- Suspension, Extended Release
Therapeutic Class: Antitussive, Opioid/Antihistamine Combination
Pharmacologic Class: Chlorpheniramine
Chemical Class: Chlorpheniramine
Uses For hydrocodone and chlorpheniramine polistirex
Hydrocodone and chlorpheniramine polistirex combination is used to treat cough and respiratory symptoms associated with a cold or allergy.
Hydrocodone polistirex is a narcotic cough suppressant. It acts directly on the cough center in the brain to prevent a cough. Chlorpheniramine polistirex is an antihistamine that treats or prevents the symptoms of an allergy.
When hydrocodone polistirex is used for a long time, it may become habit-forming. This could cause mental or physical dependence. Physical dependence may lead to unwanted withdrawal effects if hydrocodone is stopped suddenly. Talk to your doctor if you have questions.
hydrocodone and chlorpheniramine polistirex is available only with your doctor's prescription.
Before Using hydrocodone and chlorpheniramine polistirex
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For hydrocodone and chlorpheniramine polistirex, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to hydrocodone and chlorpheniramine polistirex or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Because of the toxicity of hydrocodone polistirex, use in children younger than 6 years of age is not permitted. Hydrocodone has caused serious breathing problems in young children, sometimes causing death. Hydrocodone and chlorpheniramine polistirex combination should be used with caution in children 6 years of age and older.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydrocodone and chlorpheniramine polistirex combination in the elderly. However, elderly patients are more likely to develop age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving hydrocodone and chlorpheniramine polistirex.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking hydrocodone and chlorpheniramine polistirex, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using hydrocodone and chlorpheniramine polistirex with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using hydrocodone and chlorpheniramine polistirex with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Chloral Hydrate
- Methylene Blue
- Morphine Sulfate Liposome
- Nitrous Oxide
- Opium Alkaloids
- Secretin Human
- Sodium Oxybate
- Tolonium Chloride
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using hydrocodone and chlorpheniramine polistirex with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use hydrocodone and chlorpheniramine polistirex, or give you special instructions about the use of food, alcohol, or tobacco.
- Grapefruit Juice
Other Medical Problems
The presence of other medical problems may affect the use of hydrocodone and chlorpheniramine polistirex. Make sure you tell your doctor if you have any other medical problems, especially:
- Addison disease (adrenal gland problem) or
- Asthma or
- Enlarged prostate (BPH, prostatic hypertrophy) or
- Head injury, history of or
- Hypothyroidism (underactive thyroid), severe or
- Lung or breathing problems (eg, COPD) or
- Stomach or bowel problems—May cause side effects to become worse.
- Blockage in bowels or
- Constipation or
- Glaucoma, narrow-angle or
- Problems with passing urine—Use with caution. May make these conditions worse.
- Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of hydrocodone and chlorpheniramine polistirex
Take hydrocodone and chlorpheniramine polistirex only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of hydrocodone and chlorpheniramine polistirex is taken for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.
hydrocodone and chlorpheniramine polistirex comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.
You may take the extended-release suspension with or without food.
Shake the extended-release suspension well before each use. Measure the dose with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Rinse the dosing spoon or measuring device with water after each use.
Swallow the extended-release capsule whole. Do not crush, break, or chew it.
Do not mix hydrocodone and chlorpheniramine polistirex with liquids or other medicines.
The dose of hydrocodone and chlorpheniramine polistirex will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of hydrocodone and chlorpheniramine polistirex. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For relief of cough and cold or allergy symptoms:
- For oral dosage form (extended-release capsules):
- Adults and children 12 years of age and older—One capsule every 12 hours. Each full-strength capsule contains hydrocodone 10 milligrams (mg) and chlorpheniramine 8 mg. Do not take more than 2 capsules in 24 hours.
- Children 6 to 11 years of age—One capsule every 12 hours. Each half-strength capsule contains hydrocodone 5 mg and chlorpheniramine 4 mg. Do not take more than 2 capsules in 24 hours.
- Children younger than 6 years of age—Use is not recommended.
- For oral dosage form (extended-release suspension):
- Adults and children 12 years of age and older—5 milliliters (mL) every 12 hours. Do not take more than 10 mL in 24 hours.
- Children 6 to 11 years of age—2.5 mL every 12 hours. Do not take more than 5 mL in 24 hours.
- Children younger than 6 years of age—Use is not recommended.
- For oral dosage form (extended-release capsules):
If you miss a dose of hydrocodone and chlorpheniramine polistirex, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using hydrocodone and chlorpheniramine polistirex
It is very important that your doctor check your progress while you are using hydrocodone and chlorpheniramine polistirex. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
hydrocodone and chlorpheniramine polistirex may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
Using hydrocodone and chlorpheniramine polistirex can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.
hydrocodone and chlorpheniramine polistirex may make you drowsy. Make sure you know how you react to hydrocodone and chlorpheniramine polistirex before you drive, use machines, or do anything else that could be dangerous if you are not alert.
Make sure any doctor or dentist who treats you knows that you are using hydrocodone and chlorpheniramine polistirex.
hydrocodone and chlorpheniramine polistirex will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using hydrocodone and chlorpheniramine polistirex.
If you think you or someone else may have taken an overdose of hydrocodone and chlorpheniramine polistirex, get emergency help at once. Signs of an overdose include: pale or blue lips, fingernails, or skin, confusion, difficult or troubled breathing, irregular, fast or slow, or shallow breathing, extreme sleepiness or drowsiness, cold and clammy skin, or lightheadedness or fainting.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
hydrocodone and chlorpheniramine polistirex Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:Incidence not known
- Decrease in frequency of urination
- decrease in urine volume
- difficult, painful, or troubled breathing
- difficulty in passing urine (dribbling)
- irregular, fast or slow, or shallow breathing
- pale or blue lips, fingernails, or skin
- tightness in the chest
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
- false or unusual sense of well-being
- fear or nervousness
- itching skin or rash
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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