Cabozantinib and Fatigue: What Users Say

• Mis...
• September 4, 2018

For Renal Cell Carcinoma "My husband was on 60 mg cabozantinib for about 7 weeks with limited side effects. His blood pressure was stable and fatigue was minimal. He did not have much mouth sensitivity or hand/foot soreness. During this time, he felt better and stronger than he had in a long time. This did not last. One of the serious side effects of this drug is internal bleeding. Last week, my husband died of a sudden internal pulmonary hemorrhage. It is impossible to know why this happened, however, I feel it is important to share his experience."

• GDG...
• Taken for 5 to 10 years
• May 6, 2025

For Renal Cell Carcinoma "I’m a 63-year-old male diagnosed with RCC in 2008 (I was 47 then). I had a left nephrectomy in 2008 and the RCC returned in my left lung in 2017. After surgery, the RCC returned in my left hilar lymph node and was inoperable. I started on 60 mg of cabozantinib daily in February of 2019. After 60 days, the tumor had shrunk from over 20 mm down to 12 mm. My son told me I looked like a ghost, but the drug was working. After 4 months, we reduced the cabozantinib dose from 60 mg to 40 mg. The 60 mg dose was more difficult and caused frequent diarrhea, peeling skin on my hands, and loss of energy. The 40 mg dose was more tolerable, and I continued on it for about a year - still had regular diarrhea and less energy, but mostly manageable. I have been on a 20 mg dose and just started my 7th year on this treatment. I don’t have the energy that I used to have, and my tumor has very slowly started to grow. It’s a great drug."

• Rav...
• Taken for 1 to 6 months
• November 6, 2018

Cabozantinib for Thyroid Cancer "'This drug is not good.' My father was on 60 mg Cabozantinib for about 5 weeks with a lot of side effects. His BP is normal, but fatigue is still there, and he can't walk without support. His hands, feet, and whole body were numb. He can't walk more than 10 steps. Also, every day before or after taking food, he is vomiting, which is still continuing. His weight before we started Cometriq (Cabozantinib) was 52.5 kg, and now his weight is 45 kg. Today I decided to stop this medicine. So expensive for a medicine that does nothing. The best way to earn money is to play with people's emotions. This method is not good for the patient and the patient's family."