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Cabozantinib Dosage

Medically reviewed by Drugs.com. Last updated on Aug 13, 2024.

Applies to the following strengths: 80 mg-20 mg (140 mg daily-dose); 80 mg-20 mg (100 mg daily-dose); 20 mg (60 mg daily-dose); 60 mg; 20 mg; 40 mg

Usual Adult Dose for Thyroid Cancer

Capsules: 140 mg orally once a day until patient no longer experiences clinical benefit or unacceptable toxicity occurs
Tablets: BSA greater than or equal to 1.2 m(2): 60 mg once a day until disease progression or unacceptable toxicity

Comments:


Uses:

Usual Adult Dose for Renal Cell Carcinoma

Tablets:


Comments:

Uses:

Usual Adult Dose for Hepatocellular Carcinoma

Tablets: 60 mg orally once a day until patient no longer experiences clinical benefit or unacceptable toxicity occurs

Comments:


Use: For patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib

Usual Pediatric Dose for Thyroid Cancer

Tablets: BSA greater than or equal to 1.2 m(2): 60 mg once a day until disease progression or unacceptable toxicity
Tablets: BSA less than 1.2 m(2): 40 mg once a day until disease progression or unacceptable toxicity

Comments:


Use: For the treatment of pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine-refractory or ineligible

Renal Dose Adjustments

Capsules/Tablets:

Liver Dose Adjustments

Capsule formulation (MTC):


Tablet formulation (MTC):

Tablet formulation (RCC):

Dose Adjustments

CAPSULE FORMULATION (MTC):


TABLET FORMULATION (RCC):

TABLET FORMULATION (RCC):

TABLET FORMULATION (RCC) IN COMBINATION WITH NIVOLUMAB:

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration Advice:


Storage Requirements:

Monitoring:

Patient Advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.