Abaloparatide and Tiredness: What Users Say

• con...
• Taken for 1 to 2 years
• June 21, 2023

Abaloparatide for Osteoporosis "I used Tymlos from Mar 22 to Feb 23. From the first injection, I experienced a rapid heart rate, dull aching in my mid-back kidney area, frequent urination, and some dizziness. I used it before bed due to the side effects. If I got up at night, I was often disoriented. The injections also sometimes caused bruising and pain. After 2 months, I began using it every other day due to the side effects, even though these were primarily at night. But I was really tired due to getting up at night to use the bathroom. I was optimistic about this drug as it is designed to grow bone, rather than just stop bone loss like biophosphonates, and I was willing to continue treatment for another year. Super disappointed with my DEXA bone scan results and stopped Tymlos due to essentially zero benefits: Hip: -2.9. Prior -2.8, slight decrease; Femoral neck: -3.4. Prior -2.9, major decrease; Lumbar spine: -2.2. Prior -2.2, no change. For me, Tymlos was not effective. Blessings on the journey toward stronger bones."

• Chr...
• Taken for 1 to 2 years
• August 4, 2020

Abaloparatide for Osteoporosis "Did not do well on Tymlos. High 24 hr. urine Ca. scores - hypercalciuria. Started Tymlos June 2019, stopped April 11, 2020. Other issues: cramps in legs, mental fog starting second month, joint pain in hands, tiredness on a daily basis. Got new rheumatologist, second opinion. Started Prolia today. Should have monitored bone markers more carefully both before and during treatment of Tymlos. Now I know. New doc. will do blood tests and urine every 3 months. Tymlos not for me."

• Ann...
• Taken for less than 1 month
• April 6, 2020

Abaloparatide for Osteoporosis "I started Tymlos on 3/12/20 and decided to discontinue it due to heart palpitations and anxiety. I also had terrible insomnia with it. I took the injection at night before bed, but when I tried taking the injection in the morning, I would have to lie down because it made me so tired (go figure). With all of the COVID-19 worries, I sure don't need my heart racing any more than it already is. Also, the black box warning of osteosarcoma worries me a lot, frankly."

• Bar...
• April 19, 2021

Abaloparatide for Osteoporosis "I am just now starting my 4th month. I don’t have any serious side effects; however, I was already being treated for heart palpitations, so that may be why! I do get tired during the day. Sometimes I feel like I can 'feel my bones.' My problem areas include my spine -4.7 and my hip. I plan to have a bone scan after 6 months to see if there’s been progress. If not, I’ll need to make a decision of whether or not to continue. I take my injections in the morning."

• MJD...
• Taken for 1 to 6 months
• August 1, 2022

Abaloparatide for Osteoporosis "I have been using Tymlos for 5 months and started out at only 1/2 dose '4' clicks. Tried to raise the dose every week, but when I got to '6' clicks, brain fog, dizziness, and exhaustion were too overwhelming, had difficulty walking and driving a car. So I went down to '5' clicks for the last 2 months. Even this low dose, I am exhausted, needing naps every day. Now, in the 5th month, pain in lower back is excruciating! I need a heating pad in the morning in order to be able to roll over, stand up, and walk. In addition, I have started to develop severe leg cramps at night that persist through the daytime. A nightmare. I am in communication with my doctor, we will see how this goes from here."

• Anonymous
• Taken for 1 to 6 months
• September 10, 2022

Abaloparatide for Osteoporosis "Took Tymlos for 2 months. I didn't know why I was so tired, and then I figured out it was the medication. Slept 11 hours per night for a few days and then figured it out that it was from Tymlos, so I stopped taking it. Also, I gained weight. I would not recommend it to anyone."

• Mar...
• Taken for 1 to 6 months
• March 21, 2023

Abaloparatide for Osteoporosis "I have been taking Tymlos for about 6 months now. I rarely had a side effect other than tiredness, until about 3 weeks ago, when I started having pain in my knees and legs. It gets difficult to work out or walk with this pain. I am taking Advil to help me, and I hope it gets better, I do not want to stop the medication. I hope it helps me with my osteo. Doing a scan after my first year of treatment to see if my bones have improved."

• Ano...
• Taken for 1 to 2 years
• May 2, 2025

Abaloparatide for Osteoporosis "I have been using Tymlos for 13 months. Shortly after I started it, I noticed that my abdomen was getting bigger and then I began to gain weight. I also noticed that I felt tired and did not have a lot of energy. As time has gone on, I feel drained by the middle of the day. Through these side effects, I continue to walk in the park 3 times per week for about 45 minutes and I do my P.T. at home. It is a struggle many days, but I just keep on keeping on! I will be very happy when I no longer have to use this medication and I don't plan on using any other medication after Tymlos. I take calcium and vitamin D twice a day and try hard to eat a high-protein diet."

• Bam...
• Taken for less than 1 month
• December 29, 2021

Abaloparatide for Osteoporosis "Day 1: headache and tired (ibuprofen did not help). Day 2: severe headache almost immediately and really tired, dizzy, had to just lay down. Left a message for my doctor, but it’s the week between Christmas and New Year’s, so probably limited staff. Will these symptoms go away? I’m afraid to try day 3."

• Dia...
• Taken for less than 1 month
• March 12, 2018

For Osteoporosis "This prescription has made me very tired. All I wanted to do is sleep. It has also caused wheezing. When I was on for 3 days in a row, then off every other day, the wheezing and breathing got better. Then I was instructed to go back on every day, and by day 3, wheezing, coughing, and shortness of breath took over. I took myself off completely at day 3, and it's been 3 weeks, and I'm still tired and coughing with shortness of breath."

• Ano...
• Taken for 1 to 6 months
• May 10, 2025

Abaloparatide for Osteoporosis "Weight loss, dizziness, skin rash, lethargy, apathy, anhedonia. Most of this is tolerable. I’ve requested a bone scan after 6 months to see if it’s helping."

• Che...
• Taken for less than 1 month
• May 18, 2025

Abaloparatide for Osteoporosis "I started Tymlos 4/14/25. I haven't really gotten much of any side effects. Just a bit more tired. I pray for all users to give it a good try."