Abaloparatide and Insomnia: What Users Say

• Bel...
• September 25, 2020

For Osteoporosis "I used Tymlos for 3 months initially. Prior to my first injection, my blood pressure was perfect. After the injection, my BP would climb to 185-195/90-95 and the heart palpitations would start. At night, insomnia and leg cramps would arrive. My doctor took me off for one month - no heart palpitations, no insomnia, no leg cramps and blood pressure back to 115/65. My doctor asked me to start again. This time it was worse. BP even higher and heart palpitations more pronounced - extreme chest pains, as well. The leg cramps were brutal and my Achilles tendon in my left leg started hurting and burning. Eight years ago I ruptured it in TRX as a result of being on Levaquin. For seven years I have had no pain, no issues whatsoever in exercising until I restarted the Tymlos. I just went in for an MRI, the Achilles repair is intact - however, I now have damage just above - the tendon has thinned and I am on severe restrictions to avoid another rupture. I am off of Tymlos."

• Bro...
• Taken for less than 1 month
• July 27, 2020

For Osteoporosis "I have had 5 compression fractures and 1 broken rib since 51. I'm now 55. My osteoporosis is from prednisone. I was tall at 5'9, now I am 5'4 and my organs are being crushed. I have a hunchback from repeated compression fractures. My neck is like 4 inches forward. I've lost most of my mobility. Can barely get out of a chair or bed. I can't garden anymore or do chores. No choice but to take big pharma poisons again. Taking Tymlos for 5 days now. Had no side effects until night 4, so I take it at night. I inject it into the fatty part of my thigh. On day 4, could not sleep a wink. Heart racing, whole body neuropathy, stomach pains, gas, heartburn, dizziness, leg pain. Oh joy, now this for 18 months. It better grow bone. I've read that if you get a compression fracture, you should get a kyphoplasty to stabilize the fracture, regain vertebral height, and get out of pain to avoid a hunchback. The medical field and big pharma aren't here to help, just to live in a nightmare that I cannot awake from."

• Rod...
• Taken for less than 1 month
• December 21, 2020

For Osteoporosis "I wanted to update my experience. Now after having been on Tymlos for 2 weeks, I am happy to report the side effects disappeared after the first week. I also injected on alternate days for the 1st week which helped a lot. Injecting before bed was a big mistake for an insomniac like me. Just made me focus on my elevated pulse. I find injecting just before I exercise works great."

• Ann...
• Taken for less than 1 month
• April 6, 2020

For Osteoporosis "I started Tymlos on 3/12/20 and decided to discontinue it due to heart palpitations and anxiety. I also had terrible insomnia with it. I took the injection at night before bed, but when I tried taking the injection in the morning, I would have to lie down because it made me so tired (go figure). With all of the COVID-19 worries, I sure don't need my heart racing any more than it already is. Also, the black box warning of osteosarcoma worries me a lot, frankly."

• Anonymous
• November 22, 2020

For Osteoporosis "Six Tymlos injections so far at half dose (4 clicks). First-day side effects were just feeling odd. Trouble sleeping on night 2. With the first few injections, there were hot flashes, shocks, and pains that quickly moved around my body. Also, headaches that lasted about 20 hours and muscle pains as if I'd been in a car accident. I wondered if the benefits could outweigh the sense that my body was being poisoned. After the fourth dose, things started calming down some. The most persistent effect is a tolerable pain in my lower left back that began with the first injection and hasn't gone away yet. I was told to ramp up the dose from half (4 clicks) to 5 clicks on the 5th night. Not wanting more bad side effects, I have put that off. The PA who prescribed indicated that some people can't tolerate going up from a half dose. If that's me, I wonder, will half a dose do any good for my bones? Or will I inject myself and go through side effects for 2 years for no benefit?"

• Jan...
• Taken for 1 to 6 months
• October 14, 2021

For Osteoporosis "I have been on Tymlos for two months. I immediately had a drop in my blood pressure. I then had pressure behind my eyes and was off Tymlos for two weeks. I restarted but found that my blood pressure still dropped, and I had a racing heart rate as well as insomnia. After being off of it again for two days, I have felt lightheaded, and my pulse slowed to what was not normal for me, a drop of 10 to 15 beats per minute. I have come to the conclusion that the risks and side effects are not worth it. As I have dental issues, I cannot take other medications. Forteo is the only other alternative, and it is the same class of medication and has similar or maybe more side effects."

• Wyt...
• Taken for less than 1 month
• November 1, 2021

For Osteoporosis "I'm on my fifth injection. My numbers were 4.7 in the left hip. My calcium and vitamin D are excellent, so I can't improve with nutrition. I didn't get any instructions; the VA sent me the pen and, later, the needles. When I asked for instruction, they told me to look at the YouTube videos, which I did. Bunches of them, but they don't tell you where to inject or what to look for after. No one mentions all the stuff you all are telling me. So, I'm sorry, but glad to hear the back pain, palpitations, insomnia, brain fog, general malaise, severe headache, and pains in my legs and ankles are fairly typical. I'm not surprised at the health care professionals dismissing our concerns. After all, years of living with the pain of a condition and knowing our own bodies are not equivalent to that two-week course the health provider took. I experience burning and itching at the injection site that seems to grow bigger with each injection. It was the first time the needle actually hurt... a lot."

• Ano...
• Taken for 1 to 6 months
• April 8, 2025

For Osteoporosis "Started Tymlos full dose, and it made me feel odd, but tolerable. The palpitations were better after one week. Then I got bone pain in my leg-very different from any pain I've had before! Woke me up. After skipping it for a few days, the pain went away, so I started back 2 clicks (20 mg) and am up to 5 clicks (50 mg), but starting to get insomnia. I'm a bit into investigating. I found a dose response clinical trial that shows that 40 mg works half as well as 80 mg, but it still works! Even 20 mg has a positive effect. So I may stay with a half dose until I give up and switch to something else."

• Ban...
• Taken for 1 to 6 months
• June 28, 2020

For Osteoporosis "On Tymlos for 3 months, severe insomnia."

• tss...
• Taken for 1 to 2 years
• February 23, 2025

For Osteoporosis "Dizziness, digestive problems, fatigue, and bone pain to varying degrees. Also caused severe insomnia that occurs in cycles. If it weren’t working, I’d never stick with it."