Abaloparatide Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 13, 2024.

Applies to abaloparatide: subcutaneous solution.

Serious side effects of abaloparatide

Along with its needed effects, abaloparatide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking abaloparatide:

More common side effects

• blood in the urine
• constipation
• depression
• loss of appetite
• loss of weight
• muscle weakness
• nausea or vomiting
• pain in the bone, joint, back, arms, or legs
• pain in the side, back, or stomach
• thirst
• unusual tiredness or weakness

Less common side effects

• fast, irregular, pounding, or racing heartbeat or pulse

Incidence not known

• chest tightness
• cough
• difficulty swallowing
• dizziness
• fast heartbeat
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• trouble breathing

Other side effects of abaloparatide

Some side effects of abaloparatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• difficulty in moving
• headache
• muscle pain or stiffness

Less common side effects

• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
• feeling of constant movement of self or surroundings
• sensation of spinning
• unusual bruising

Incidence not known

• diarrhea
• full or bloated feeling
• general feeling of discomfort or illness
• itching, rash
• lack or loss of strength
• muscle spasms of the leg and back
• pressure in the stomach
• swelling of the stomach area
• trouble sleeping
• unusual drowsiness, dullness, or feeling of sluggishness

For healthcare professionals

Applies to abaloparatide: subcutaneous solution.

General adverse events

The most common side effects resulting in discontinuation were nausea, dizziness, headache, and palpitations.

Cardiovascular

• Common (1% to 10%): Palpitations, tachycardia (including sinus tachycardia), orthostatic hypotension^[Ref]

Dermatologic

• Postmarketing reports: Pruritus, rash

Gastrointestinal

• Common (1% to 10%): Nausea, upper abdominal pain, abdominal distention, diarrhea
• Postmarketing reports: Abdominal distention, abdominal pain, constipation, diarrhea, vomiting^[Ref]

Hypersensitivity

• Postmarketing reports: Hypersensitivity and anaphylactic reaction

Immunologic

• Very common (10% or more): Immunogenicity^[Ref]

Local

• Very common (10% or more): Redness at injection site (58%), edema at injection site (11%), pain at injection site (10%)
• Common (1% to 10%): Contusion at injection site
• Postmarketing reports: Injection site bruising, hemorrhage^[Ref]

Metabolic

• Very common (10% or more): Increased serum uric acid (25%)
• Common (1% to 10%): Hypercalcemia^[Ref]

Nervous system

• Very common (10% or more): Dizziness (10%)
• Common (1% to 10%): Headache
• Postmarketing reports: Lethargy^[Ref]

Other

• Common (1% to 10%): Fatigue, vertigo
• Postmarketing reports: Asthenia, malaise

Psychiatric

• Postmarketing reports: Insomnia

Renal

• Very common (10% or more): Hypercalciuria (20%)
• Common (1% to 10%): Urolithiasis^[Ref]

Respiratory

• Postmarketing reports: Dyspnea

Musculoskeletal

• Common (1% to 10%): Arthralgia, bone pain
• Postmarketing reports: Bone pain, joint pain, back pain, extremity pain, leg and back muscle spasms

Frequently asked questions

• Can Tymlos cause bone cancer?

Further information

Abaloparatide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer