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Siliq

Generic Name: Brodalumab (broe DAL ue mab)
Brand Name: Siliq

Medically reviewed on Sep 5, 2018

Warning

  • Patients who take Siliq (brodalumab) may be at a greater risk of having thoughts or actions of suicide. Some people taking Siliq (brodalumab) have killed themselves (suicide). The risk may be greater in people who have had these thoughts or actions in the past. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
  • You may only get Siliq (brodalumab) through a special program. Talk with your doctor.

Uses of Siliq:

What do I need to tell my doctor BEFORE I take Siliq?

  • If you have an allergy to Siliq (brodalumab) or any part of Siliq (brodalumab).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have Crohn's disease.
  • If you have active TB (tuberculosis).

This is not a list of all drugs or health problems that interact with Siliq (brodalumab).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Siliq (brodalumab) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Siliq?

  • Tell all of your health care providers that you take Siliq (brodalumab). This includes your doctors, nurses, pharmacists, and dentists.
  • Have patient safety card with you at all times.
  • You will need a TB (tuberculosis) test before starting Siliq (brodalumab).
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • Talk with your doctor before getting any vaccines. Use with Siliq (brodalumab) may either raise the chance of an infection or make the vaccine not work as well.
  • This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking Siliq (brodalumab) with your other drugs.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Siliq (brodalumab) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Siliq) best taken?

Use Siliq (brodalumab) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into the fatty part of the skin on the top of the thigh, belly area, or upper arm.
  • If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
  • Follow how to use as you have been told by the doctor or read the package insert.
  • If stored in a refrigerator, let Siliq (brodalumab) come to room temperature before using it. Leave it at room temperature for at least 30 minutes. Do not heat Siliq (brodalumab).
  • Do not give into skin that is irritated, bruised, red, infected, or scarred.
  • Do not give into skin that is affected by psoriasis.
  • Do not shake.
  • This medicine is colorless to a faint yellow. Do not use if the solution changes color.
  • This product is clear but may contain a few particles. Do not use if the solution is cloudy, leaking, or has more than a few particles.
  • Each prefilled syringe is for one use only.
  • Throw away any part left over after the dose is given.
  • Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of Crohn's disease like bloody stools, constipation or diarrhea, fever, not able to control bowels, not hungry, painful diarrhea, stomach pain or cramps, sudden need to have a bowel movement, tiredness, or weight loss.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Warm, red, or painful skin or sores on the body.
  • Sweating a lot.
  • Muscle pain or weakness.
  • Shortness of breath.
  • Passing urine more often.

What are some other side effects of Siliq?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Siliq?

  • Store in a refrigerator. Do not freeze.
  • Store in the carton to protect from light.
  • If needed, you may store at room temperature for up to 14 days. Write down the date you take Siliq (brodalumab) out of the refrigerator. If stored at room temperature and not used within 14 days, throw Siliq (brodalumab) away.
  • Do not put Siliq (brodalumab) back in the refrigerator after it has been stored at room temperature.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Siliq (brodalumab) is refilled. If you have any questions about Siliq (brodalumab), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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