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Siliq Side Effects

Generic Name: brodalumab

Note: This document contains side effect information about brodalumab. Some of the dosage forms listed on this page may not apply to the brand name Siliq.

In Summary

Common side effects of Siliq include: infection. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to brodalumab: subcutaneous solution

Along with its needed effects, brodalumab (the active ingredient contained in Siliq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brodalumab:

Less Common

  • Black, tarry stools
  • chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • painful or difficult urination
  • pale skin
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Incidence Not Known

  • Changes in behavior
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • thoughts of killing oneself
  • trouble concentrating
  • trouble sleeping

Some side effects of brodalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less Common

  • Difficulty with moving
  • muscle pain or stiffness
  • pain in the joints
  • pain, redness, burning, or itching at the injection site

For Healthcare Professionals

Applies to brodalumab: subcutaneous solution

Gastrointestinal

Common (1% to 10%): Diarrhea, oropharyngeal pain, nausea[Ref]

Hematologic

Common (1% to 10%): Neutropenia[Ref]

Genitourinary

Frequency not reported: Urinary tract infection[Ref]

Other

Common (1% to 10%): Fatigue[Ref]

Immunologic

Common (1% to 10%): Influenza, tinea infections (i.e., tinea pedis, tinea versicolor, tinea cruris), immunogenicity

Uncommon (0.1% to 1%): Candida infections (i.e., oral, genital, esophageal)[Ref]

Local

Common (1% to 10%): Injection site reactions (i.e., pain, erythema, bruising, hemorrhage, pruritus)[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, myalgia[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis[Ref]

Respiratory

Frequency not reported: Nasopharyngitis, upper respiratory tract infection, pharyngitis, bronchitis[Ref]

Psychiatric

Uncommon (0.1% to 1%): Suicidal ideation or behavior[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Siliq (brodalumab)." Valeant Pharmaceuticals, Costa Mesa, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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