Siliq Side Effects

Generic name: brodalumab

Medically reviewed by Drugs.com. Last updated on Jan 5, 2025.

Note: This document provides detailed information about Siliq Side Effects associated with brodalumab. Some dosage forms listed on this page may not apply specifically to the brand name Siliq.

Applies to brodalumab: subcutaneous solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

You will need to have a skin test for tuberculosis before you start using this medicine. Tell your doctor if you or anyone in your home has ever had a positive reaction to a tuberculosis skin test.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors, such as feeling sad or hopeless, getting upset easily, or feeling nervous or hostile. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away.

It is important to check with your doctor if you have any symptoms of an infection such as fever or chills, cough or hoarseness, lower back or side pain, painful or difficult urination.

Do not have any live vaccines (immunizations) while you are being treated with brodalumab (the active ingredient contained in Siliq) Be sure to ask your doctor if you have any questions about this.

Tell your doctor if you have bloody diarrhea, a fever, or severe stomach pain after receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Siliq

Along with its needed effects, brodalumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brodalumab:

Other side effects of Siliq

Some side effects of brodalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to brodalumab: subcutaneous solution.

Gastrointestinal adverse events

• Common (1% to 10%): Diarrhea, oropharyngeal pain, nausea^[Ref]

Hematologic

• Common (1% to 10%): Neutropenia^[Ref]

Genitourinary

• Frequency not reported: Urinary tract infection^[Ref]

Other

• Common (1% to 10%): Fatigue^[Ref]

Immunologic

• Common (1% to 10%): Influenza, tinea infections (i.e., tinea pedis, tinea versicolor, tinea cruris), immunogenicity
• Uncommon (0.1% to 1%): Candida infections (i.e., oral, genital, esophageal)^[Ref]

Local

• Common (1% to 10%): Injection site reactions (i.e., pain, erythema, bruising, hemorrhage, pruritus)^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia, myalgia^[Ref]

Nervous system

• Common (1% to 10%): Headache^[Ref]

Ocular

• Uncommon (0.1% to 1%): Conjunctivitis^[Ref]

Respiratory

• Frequency not reported: Nasopharyngitis, upper respiratory tract infection, pharyngitis, bronchitis^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Suicidal ideation or behavior^[Ref]

See also:

Frequently asked questions

• What are the new drugs for plaque psoriasis?
• What is the Siliq REMS Program?

Further information

Siliq side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer