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Siliq Side Effects

Generic Name: brodalumab

Note: This document contains side effect information about brodalumab. Some of the dosage forms listed on this page may not apply to the brand name Siliq.

For the Consumer

Applies to brodalumab: subcutaneous solution

Along with its needed effects, brodalumab (the active ingredient contained in Siliq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brodalumab:

Less common
  • Black, tarry stools
  • chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • painful or difficult urination
  • pale skin
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
Incidence not known
  • Changes in behavior
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • thoughts of killing oneself
  • trouble concentrating
  • trouble sleeping

Some side effects of brodalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Difficulty with moving
  • muscle pain or stiffness
  • pain in the joints
  • pain, redness, burning, or itching at the injection site

For Healthcare Professionals

Applies to brodalumab: subcutaneous solution


Common (1% to 10%): Diarrhea, oropharyngeal pain, nausea[Ref]


Common (1% to 10%): Neutropenia[Ref]


Frequency not reported: Urinary tract infection[Ref]


Common (1% to 10%): Fatigue[Ref]


Common (1% to 10%): Influenza, tinea infections (i.e., tinea pedis, tinea versicolor, tinea cruris), immunogenicity
Uncommon (0.1% to 1%): Candida infections (i.e., oral, genital, esophageal)[Ref]


Common (1% to 10%): Injection site reactions (i.e., pain, erythema, bruising, hemorrhage, pruritus)[Ref]


Common (1% to 10%): Arthralgia, myalgia[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Uncommon (0.1% to 1%): Conjunctivitis[Ref]


Frequency not reported: Nasopharyngitis, upper respiratory tract infection, pharyngitis, bronchitis[Ref]


Uncommon (0.1% to 1%): Suicidal ideation or behavior[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Siliq (brodalumab)." Valeant Pharmaceuticals, Costa Mesa, CA.

Some side effects of Siliq may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.