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Rinvoq

Generic Name: Upadacitinib (ue PAD a SYE ti nib)
Brand Name: Rinvoq

Medically reviewed by Drugs.com. Last updated on Sep 9, 2019.

Warning

  • Very bad and sometimes deadly infections have happened in patients who take Rinvoq (upadacitinib). Most people who had these infections were taking other drugs to lower the immune system like methotrexate or steroid drugs. If you have any infection, are taking antibiotics now or in the recent past, or have had many infections, talk with your doctor.
  • TB (tuberculosis) has been seen in patients started on Rinvoq (upadacitinib). These patients were exposed to TB in the past, but never got the infection. You will be tested to see if you have been exposed to TB before starting Rinvoq (upadacitinib).
  • Lymphoma and other cancers have happened in people who take Rinvoq (upadacitinib) or drugs like it. This has been deadly in some cases. Talk with the doctor.
  • Blood clots have happened with drugs like this one. Tell your doctor if you have ever had a blood clot.

Uses of Rinvoq:

What do I need to tell my doctor BEFORE I take Rinvoq?

  • If you have an allergy to Rinvoq (upadacitinib) or any part of Rinvoq (upadacitinib).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have low red or white blood cell counts.
  • If you have liver disease or raised liver enzymes.
  • If you have an infection.
  • If you are using another drug like this one. If you are not sure, ask your doctor or pharmacist.
  • If you take any other drugs (prescription or OTC, natural products, vitamins). There are many drugs that interact with Rinvoq (upadacitinib), like certain drugs that are used for HIV, infections, or seizures.
  • If you are breast-feeding. Do not breast-feed while you take Rinvoq (upadacitinib) and for 6 days after your last dose.

This is not a list of all drugs or health problems that interact with Rinvoq (upadacitinib).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Rinvoq (upadacitinib) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Rinvoq?

  • Tell all of your health care providers that you take Rinvoq (upadacitinib). This includes your doctors, nurses, pharmacists, and dentists.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • If you have had hepatitis B before or carry the virus, talk with your doctor. Drugs like this one can cause the virus to become active. This can lead to very bad and sometimes deadly liver problems.
  • Hepatitis B testing needs to be done as you were told by the doctor. Talk with the doctor.
  • Some viral infections like herpes zoster have become active again with Rinvoq (upadacitinib). Tell your doctor if you have ever had a viral infection like herpes zoster. Talk with your doctor.
  • Make sure you are up to date with all your vaccines before treatment with Rinvoq (upadacitinib).
  • Talk with your doctor before getting any vaccines. Use of some vaccines with Rinvoq (upadacitinib) may either raise the chance of an infection or make the vaccine not work as well.
  • Do not get a weakened bacteria like BCG for bladder cancer while you use Rinvoq (upadacitinib). Talk with your doctor.
  • High cholesterol has happened with Rinvoq (upadacitinib). If you have questions, talk with the doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Have your skin checked. Tell your doctor if you have any skin changes like a new wart, skin sore or reddish bump that bleeds or does not heal, or a change in the color or size of a mole.
  • Holes in the GI (gastrointestinal) tract may rarely happen.
  • If you are 65 or older, use Rinvoq (upadacitinib) with care. You could have more side effects.
  • This medicine may cause harm to an unborn baby. A pregnancy test will be done before you start Rinvoq (upadacitinib) to show that you are NOT pregnant.
  • Women must use birth control while taking Rinvoq (upadacitinib) and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.

How is this medicine (Rinvoq) best taken?

Use Rinvoq (upadacitinib) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • Swallow whole. Do not chew, break, or crush.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Warm, red, or painful skin or sores on the body.
  • A skin lump or growth.
  • Feeling very tired or weak.
  • Stomach pain that is new or worse.
  • Change in bowel habits.
  • Call your doctor right away if you have a swollen gland, night sweats, shortness of breath, or weight loss without trying.
  • Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.

What are some other side effects of Rinvoq?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Rinvoq?

  • Store in the original container at room temperature or in a refrigerator.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Rinvoq (upadacitinib) is refilled. If you have any questions about Rinvoq (upadacitinib), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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