Generic Name: medroxyprogesterone (med-ROX-ee-proe-JES-ter-one)
Brand Name: Provera
Medroxyprogesterone combined with estrogen should not be used to prevent heart disease, heart attacks, strokes, or dementia. Progestin hormones combined with estrogen may increase the risk of heart disease (including heart attack), stroke, dementia, serious blood clots (eg, those in the lungs or legs), and breast cancer in some women. Talk with your doctor if you have questions about the benefits and risks of using medroxyprogesterone.
Medroxyprogesterone should be used for the shortest possible time at the lowest effective dose to minimize the risk of these side effects. Talk with your doctor regularly about your need to use medroxyprogesterone.
Medroxyprogesterone is used for:
Treating certain menstrual problems (eg, abnormal bleeding, lack of menstrual period). It is used to decrease the risk of uterine cancer in certain women taking estrogen. It may also be used for otherconditions as determined by your doctor.
Medroxyprogesterone is a progestin hormone. It works by altering the lining of the uterus.
Do NOT use medroxyprogesterone if:
- you are allergic to any ingredient in medroxyprogesterone
- you are pregnant or think you may be pregnant
- you have undiagnosed abnormal vaginal bleeding
- you have blood clots (eg, those in the lungs or legs) or a history of blood clots
- you have known or suspected breast cancer or another estrogen- or progesterone-dependent cancer, or you have a history of breast cancer
- you have a history of liver problems or liver disease
- you have had a heart attack or stroke within the past 12 months
- it is being used to test for pregnancy
Contact your doctor or health care provider right away if any of these apply to you.
Before using medroxyprogesterone:
Some medical conditions may interact with medroxyprogesterone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have had a miscarriage
- if you have a history of asthma, the blood disease porphyria, mental or mood problems (eg, depression), diabetes, eye or vision problems, fluid retention or swelling (edema), gallbladder or pancreas problems, heart problems, high blood pressure, stroke or bleeding in the brain, high cholesterol or triglyceride levels, kidney problems, high or low blood calcium levels, lupus, migraines, seizures (eg, epilepsy), or thyroid problems
- if you have had yellowing of the eyes or skin during pregnancy or with past estrogen use
- if you have a history of an abnormal mammogram or breast lumps, endometriosis, or ovarian canceror if a family member has had breast cancer
- if a family member has a history of blood clots (eg, those in the legs or lungs)
- if you smoke, use tobacco products, or are very overweight
- if you have had your uterus removed (hysterectomy)
- if you will be having surgery or will be confined to a bed or chair for a period of time
Some MEDICINES MAY INTERACT with medroxyprogesterone. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Aprepitant or rifamycins (eg, rifampin) because they may decrease medroxyprogesterone's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if medroxyprogesterone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use medroxyprogesterone:
Use medroxyprogesterone as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with medroxyprogesterone. Talk to your pharmacist if you have questions about this information.
- Take medroxyprogesterone by mouth with or without food.
- Take medroxyprogesterone at the same time every day, with doses not more than 24 hours apart.
- If you miss a dose of medroxyprogesterone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use medroxyprogesterone.
Important safety information:
- Medroxyprogesterone may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use medroxyprogesterone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Medroxyprogesterone may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker. If patches develop, consult your doctor about the use of sunscreen or protective clothing when your skin is exposed to the sun, sunlamps, or tanning booths.
- Diabetes patients - Medroxyprogesterone may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Tell your doctor if you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight). You may need to stop taking medroxyprogesterone or take other special precautions for a period of time.
- Talk with your doctor regularly (eg, every 3 to 6 months) about whether you need to continue taking medroxyprogesterone.
- If you wear contact lenses and you develop problems with them, contact your doctor.
- Medroxyprogesterone may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking medroxyprogesterone.
- Lab tests and medical exams, including physicals and blood pressure, may be performed while you use medroxyprogesterone. You should have breast and pelvic exams, and a Pap testat least once a year. You should also have periodic mammograms as determined by your doctor. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Examine your breasts monthly as directed by your doctor. Report any lumps right away.
- Use medroxyprogesterone with caution in ELDERLY women; they may be more sensitive to its effects.
- Medroxyprogesterone should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Do not use medroxyprogesterone if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Medroxyprogesterone is found in breast milk. If you are or will be breast-feeding while you take medroxyprogesterone, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of medroxyprogesterone:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Acne; breast pain or tenderness; changes in menstrual flow, including breakthrough bleeding, spotting, or missed periods; dizziness; drowsiness; headache; mild fluid retention; mild hair loss; mild nausea or vomiting; nervousness; sleeplessness; stomach cramps or bloating; weight gain or loss.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal vaginal bleeding; breast lumps, pain, or discharge; bulging eyes; calf or leg pain, swelling, redness, or tenderness; coughing up blood; fainting; fever; mental or mood changes (eg, depression); migraines; new or worsening memory problems; severe or persistent stomach pain or tenderness; shortness of breath; sudden loss of coordination; sudden, severe, or persistent headache or dizziness; swelling; symptoms of a heart attack (eg, chest, jaw, or arm pain; fainting; sudden severe nausea or vomiting; unusual sweating; weakness); symptoms of a stroke (eg, confusion, slurred speech, one-sided weakness); vaginal discharge, itching, or odor; vision loss or other vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of medroxyprogesterone:
Store medroxyprogesterone in a tightly closed container at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep medroxyprogesterone out of the reach of children and away from pets.
- If you have any questions about medroxyprogesterone, please talk with your doctor, pharmacist, or other health care provider.
- Medroxyprogesterone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take medroxyprogesterone or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about medroxyprogesterone. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to medroxyprogesterone. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using medroxyprogesterone.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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