Generic Name: lamotrigine (la-MOE-tri-jeen)
Brand Name: Lamictal
Serious and sometimes fatal rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have rarely occurred with the use of lamotrigine. The risk of serious rash may be greater in children younger than 16 years old than in adults. Although it has not been proven, the risk may also be greater if you start taking lamotrigine at a higher dose than recommended, if you take more than the recommended dose during treatment, or if you also take a medicine called valproate (eg, valproic acid, divalproex sodium). Most of the serious rashes that have occurred with the use of lamotrigine developed within the first 2 to 8 weeks of treatment. However, serious rashes have also occurred in patients who have used lamotrigine for a longer period of time. Contact your doctor at once if you develop rash symptoms, including red, swollen, blistered, or peeling skin. Treatment with lamotrigine should be stopped if rash occurs, unless it is clearly determined that the medicine did not cause the rash. Even if lamotrigine is stopped, a rash caused by lamotrigine may still become life-threatening or cause other serious side effects (eg, permanent scarring).
Lamotrigine is used for:
Treating certain types of seizures. It may be used alone or with other medicines. It may also be used to delay the occurrence of mood problems in certain patients with bipolar disorder. It may also be used for other conditions as determined by your doctor.
Lamotrigine is an anticonvulsant. Exactly how it works is not known.
Do NOT use lamotrigine if:
- you are allergic to any ingredient in lamotrigine
- you are taking dofetilide
Contact your doctor or health care provider right away if any of these apply to you.
Before using lamotrigine:
Some medical conditions may interact with lamotrigine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances (especially other anti-seizure medicines)
- if you have liver, kidney, or heart problems; certain blood problems (eg, thalassemia); or if you receive dialysis treatment
- if you have a skin rash or have ever developed a skin rash from taking lamotrigine or any other medicines to treat seizures
- if you have a history of mental or mood problems (eg, depression) or suicidal thoughts or attempts
Some MEDICINES MAY INTERACT with lamotrigine. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Carbamazepine because it may decrease lamotrigine's effectiveness and increase the risk of side effects, such as dizziness, double vision, blurred vision, and decreased coordination
- Valproate (eg, valproic acid, divalproex sodium) because it may increase the risk of lamotrigine's side effects
- Dofetilide because the risk of its side effects may be increased by lamotrigine
- Atazanavir/ritonavir, estrogens, lopinavir/ritonavir, phenobarbital, phenytoin, primidone, rifampin, or succinimides (eg, methsuximide) because they may decrease lamotrigine's effectiveness
- Hormonal contraceptives (eg, birth control pills) because the effectiveness of both medicines may be decreased
This may not be a complete list of all interactions that may occur. Ask your health care provider if lamotrigine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use lamotrigine:
Use lamotrigine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Lamotrigine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get lamotrigine refilled.
- Take lamotrigine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Lamotrigine has a bitter taste. Do not crush or chew before swallowing. The tablet may be broken in half if your doctor tells you to do so.
- Continue to take lamotrigine even if you feel well. Do not miss any doses.
- If you miss a dose of lamotrigine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use lamotrigine.
Important safety information:
- Tell your doctor or dentist that you take lamotrigine before you receive any medical or dental care, emergency care, or surgery.
- Lamotrigine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use lamotrigine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Several weeks may pass before you feel lamotrigine's full effects. Do NOT take more than the recommended dose, change your dose, or use for longer than prescribed without checking with your doctor.
- Do not suddenly stop taking lamotrigine or change your dose without checking with your doctor. Doing so may increase seizure frequency. If you need to stop taking lamotrigine, your dose should be gradually reduced over a period of at least 2 weeks. Discuss any questions or concerns with your doctor.
- If you stop taking lamotrigine for any reason, contact your doctor right away. Do not start taking it again unless your doctor tells you to. Discuss any questions or concerns with your doctor.
- If you develop new or worsening seizures, contact your doctor right away.
- Patients who take lamotrigine may be at increased risk of suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. The risk may also be greater in patients who have had bipolar (manic-depressive) illness, or if their family members have had it. Watch patients who take lamotrigine closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
- Aseptic meningitis is a serious condition that may rarely occur with the use of lamotrigine. Symptoms may include headache, fever, chills, nausea, vomiting, stiff neck, rash, sensitivity to light, drowsiness, or confusion. Contact your doctor right away if you experience any of these effects. Discuss any questions or concerns with your doctor.
- A very bad and sometimes deadly reaction has happened with lamotrigine. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Discuss any questions or concerns with your doctor.
- Hormonal birth control (eg, birth control pills) may change the amount of lamotrigine in your blood. Talk to your doctor before you start or stop taking hormonal birth control while you are taking lamotrigine. Women who take hormonal birth control may be at greater risk of side effects during the week of inactive pills in their pack. Contact your doctor if side effects, such as dizziness, decreased coordination, or double vision, occur.
- Hormonal birth control (eg, birth control pills) may not work as well while you are using lamotrigine. Check with your doctor if you have questions about how lamotrigine might affect your hormonal birth control. Contact your doctor right away if you notice any unusual vaginal bleeding or spotting. If you wish to avoid pregnancy, talk with your doctor about the use of effective birth control methods.
- Lamotrigine may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking lamotrigine.
- Lab tests may be performed while you use lamotrigine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Different medicines may look like or have names similar to lamotrigine. Always check your medicine to make sure it is correct. If you notice any change in the appearance of your medicine (eg, shape, color, size, wording), check with your pharmacist.
- Caution is advised when using lamotrigine in CHILDREN; they may be more sensitive to its effects, especially the risk of serious rash.
- Increased sensitivity to the sun has been reported in some CHILDREN taking lamotrigine. Use a sunscreen or protective clothing if your child will be exposed to the sun. Discuss any questions or concerns with your doctor.
- PREGNANCY and BREAST-FEEDING: Lamotrigine may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using lamotrigine while you are pregnant. Lamotrigine is found in breast milk. If you are or will be breast-feeding while you use lamotrigine, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of lamotrigine:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Blurred or double vision; constipation; diarrhea; dizziness; drowsiness; headache; nausea; painful menstrual periods; runny or stuffy nose; stomach upset or pain; tiredness; trouble sleeping; vomiting; weakness; weight loss.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); absent menstrual period or other menstrual changes; calf pain or tenderness; chest pain; dark urine; decreased coordination; difficult or painful urination; fast or irregular heartbeat; fever, chills, or persistent sore throat; new or worsening mental or mood changes (eg, anxiety, depression, restlessness, irritability, panic attacks, behavior changes); new or worsening seizures; pale stools; reddened, blistered, swollen, or peeling skin; severe muscle pain or tenderness; severe or persistent dizziness or stomach pain; shortness of breath; sores in the mouth or around the eyes; suicidal thoughts or attempts; swelling of the hands, ankles, or feet; swollen lymph glands; tremor; unusual bruising or bleeding; unusual weakness or tiredness; vaginal itching or discharge; vision changes; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of lamotrigine:
Store lamotrigine at room temperature between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep lamotrigine out of the reach of children and away from pets.
- If you have any questions about lamotrigine, please talk with your doctor, pharmacist, or other health care provider.
- Lamotrigine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take lamotrigine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about lamotrigine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to lamotrigine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using lamotrigine.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about lamotrigine
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- Drug class: triazine anticonvulsants
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