Hydrochlorothiazide and Spironolactone
Generic Name: Hydrochlorothiazide and Spironolactone (hye droe klor oh THYE a zide & speer on oh LAK tone)
Brand Name: Aldactazide
Medically reviewed by Drugs.com. Last updated on Jul 26, 2019.
Uses of Hydrochlorothiazide and Spironolactone:
- It is used to treat high blood pressure.
- It is used to get rid of extra fluid.
- Spironolactone has caused tumors in animals. These studies used larger than normal doses for a long time. Use hydrochlorothiazide and spironolactone as you have been told. Do not use hydrochlorothiazide and spironolactone for health problems other than what the doctor told you.
What do I need to tell my doctor BEFORE I take Hydrochlorothiazide and Spironolactone?
- If you have an allergy to hydrochlorothiazide, spironolactone, or any other part of hydrochlorothiazide and spironolactone.
- If you are allergic to hydrochlorothiazide and spironolactone; any part of hydrochlorothiazide and spironolactone; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have any of these health problems: Addison's disease, high calcium levels, high potassium levels, kidney disease, or liver disease.
- If you are not able to pass urine.
- If you are taking any of these drugs: Amiloride, dofetilide, eplerenone, or triamterene.
- If you are taking lithium.
- If you are breast-feeding or plan to breast-feed.
This is not a list of all drugs or health problems that interact with hydrochlorothiazide and spironolactone.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take hydrochlorothiazide and spironolactone with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Hydrochlorothiazide and Spironolactone?
- Tell all of your health care providers that you take hydrochlorothiazide and spironolactone. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how hydrochlorothiazide and spironolactone affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely. Tell your doctor if you get signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Check your blood pressure as you have been told.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take hydrochlorothiazide and spironolactone.
- If you are on a low-salt or salt-free diet, talk with your doctor.
- Sometimes, hydrochlorothiazide and spironolactone may raise potassium levels in the blood. This can be deadly if it is not treated. The risk is highest in people with diabetes, kidney disease, severe illness, and in older adults. Your doctor will follow you closely to change the dose if needed.
- If you are taking a salt substitute that has potassium in it, a potassium-sparing diuretic, or a potassium product, talk with your doctor.
- If you are taking hydrochlorothiazide and spironolactone and have high blood pressure, talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- If you take cholestyramine or colestipol, talk with your pharmacist about how to take them with hydrochlorothiazide and spironolactone.
- Watch for gout attacks.
- This medicine may cause high cholesterol and triglyceride levels. Talk with the doctor.
- Tell your doctor if you have too much sweat, fluid loss, throwing up, or loose stools. This may lead to low blood pressure.
- If you have lupus, hydrochlorothiazide and spironolactone can make your lupus active or get worse. Tell your doctor right away if you get any new or worse signs.
- This medicine may make you sunburn more easily. Use care if you will be in the sun. Tell your doctor if you sunburn easily while taking this drug.
- If you are 65 or older, use hydrochlorothiazide and spironolactone with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using hydrochlorothiazide and spironolactone while you are pregnant.
How is this medicine (Hydrochlorothiazide and Spironolactone) best taken?
Use hydrochlorothiazide and spironolactone as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Keep taking hydrochlorothiazide and spironolactone as you have been told by your doctor or other health care provider, even if you feel well.
- This medicine may cause you to pass urine more often. To keep from having sleep problems, try not to take too close to bedtime.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
- Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Black, tarry, or bloody stools.
- Throwing up blood or throw up that looks like coffee grounds.
- Very bad belly pain.
- Change in balance.
- Fever or chills.
- Sore throat.
- A burning, numbness, or tingling feeling that is not normal.
- Shortness of breath.
- Any unexplained bruising or bleeding.
- For males, enlarged breasts.
- Not able to get or keep an erection.
- Period (menstrual) changes.
- Any skin change.
- This medicine can cause certain eye problems. If left untreated, this can lead to lasting eyesight loss. If eye problems happen, signs like change in eyesight or eye pain most often happen within hours to weeks of starting hydrochlorothiazide and spironolactone. Call your doctor right away if you have these signs.
- Liver problems have rarely happened with hydrochlorothiazide and spironolactone. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
What are some other side effects of Hydrochlorothiazide and Spironolactone?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Not hungry.
- Feeling sleepy.
- Upset stomach or throwing up.
- Feeling tired or weak.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Hydrochlorothiazide and Spironolactone?
- Store at room temperature.
- Protect from light.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about hydrochlorothiazide and spironolactone, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about hydrochlorothiazide / spironolactone
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 2 Reviews
- Drug class: potassium sparing diuretics with thiazides
Other brands: Aldactazide