Hydrochlorothiazide/spironolactone Interactions
There are 554 drugs known to interact with hydrochlorothiazide/spironolactone, along with 18 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 62 are major, 454 are moderate, and 38 are minor.
- View all 554 medications that may interact with hydrochlorothiazide/spironolactone
- View hydrochlorothiazide/spironolactone alcohol/food interactions (2)
- View hydrochlorothiazide/spironolactone disease interactions (18)
Most frequently checked interactions
View interaction reports for hydrochlorothiazide / spironolactone and the medicines listed below.
- Advair Diskus (fluticasone / salmeterol)
- Ambien (zolpidem)
- Aspir 81 (aspirin)
- Aspirin Low Strength (aspirin)
- Ativan (lorazepam)
- Benadryl (diphenhydramine)
- CoQ10 (ubiquinone)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flonase (fluticasone nasal)
- Lasix (furosemide)
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- MiraLAX (polyethylene glycol 3350)
- Norco (acetaminophen / hydrocodone)
- Singulair (montelukast)
- Symbicort (budesonide / formoterol)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Xarelto (rivaroxaban)
- Zyrtec (cetirizine)
Hydrochlorothiazide/spironolactone alcohol/food interactions
There are 2 alcohol/food interactions with hydrochlorothiazide / spironolactone.
Hydrochlorothiazide/spironolactone disease interactions
There are 18 disease interactions with hydrochlorothiazide / spironolactone which include:
- acidosis
- diabetes
- electrolytes/fluid
- hyperkalemia
- liver disease
- renal dysfunction
- anuria
- electrolyte losses
- liver disease
- lupus erythematosus
- renal function disorders
- hyperuricemia
- asthma
- diabetes
- hyperlipidemia
- hyperparathyroidism
- hyperuricemia
- thyroid function tests
Report options
More about hydrochlorothiazide / spironolactone
- hydrochlorothiazide/spironolactone consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (3)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: potassium sparing diuretics with thiazides
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Atenolol
Atenolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about ...
Spironolactone
Spironolactone is a potassium-sparing diuretic that is primarily used to treat heart failure, high ...
Hydrochlorothiazide
HCTZ (hydrochlorothiazide) used to treat high blood pressure (hypertension) and edema. Includes ...
Furosemide
Furosemide is a loop diuretic used to treat fluid retention and high blood pressure by increasing ...
Carvedilol
Carvedilol (Coreg) is used to treat heart failure and hypertension (high blood pressure). Includes ...
Metoprolol
Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
