Hydrochlorothiazide/spironolactone Interactions
There are 554 drugs known to interact with hydrochlorothiazide/spironolactone, along with 18 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 62 are major, 454 are moderate, and 38 are minor.
- View all 554 medications that may interact with hydrochlorothiazide/spironolactone
- View hydrochlorothiazide/spironolactone alcohol/food interactions (2)
- View hydrochlorothiazide/spironolactone disease interactions (18)
Most frequently checked interactions
View interaction reports for hydrochlorothiazide / spironolactone and the medicines listed below.
- Advair Diskus (fluticasone / salmeterol)
- Ambien (zolpidem)
- Aspir 81 (aspirin)
- Aspirin Low Strength (aspirin)
- Ativan (lorazepam)
- Benadryl (diphenhydramine)
- CoQ10 (ubiquinone)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flonase (fluticasone nasal)
- Lasix (furosemide)
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- MiraLAX (polyethylene glycol 3350)
- Norco (acetaminophen / hydrocodone)
- Singulair (montelukast)
- Symbicort (budesonide / formoterol)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Xarelto (rivaroxaban)
- Zyrtec (cetirizine)
Hydrochlorothiazide/spironolactone alcohol/food interactions
There are 2 alcohol/food interactions with hydrochlorothiazide / spironolactone.
Hydrochlorothiazide/spironolactone disease interactions
There are 18 disease interactions with hydrochlorothiazide / spironolactone which include:
- acidosis
- diabetes
- electrolytes/fluid
- hyperkalemia
- liver disease
- renal dysfunction
- anuria
- electrolyte losses
- liver disease
- lupus erythematosus
- renal function disorders
- hyperuricemia
- asthma
- diabetes
- hyperlipidemia
- hyperparathyroidism
- hyperuricemia
- thyroid function tests
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More about hydrochlorothiazide / spironolactone
- hydrochlorothiazide/spironolactone consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (3)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: potassium sparing diuretics with thiazides
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
