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Hydrochlorothiazide / Spironolactone Dosage

Medically reviewed by Drugs.com. Last updated on Feb 23, 2023.

Applies to the following strengths: 25 mg-25 mg; 50 mg-50 mg

Usual Adult Dose for Hypertension

Hydrochlorothiazide 50 to 100 mg-Spironolactone 50 to 100 mg orally daily in 1 to 2 divided doses

Uses:

Usual Adult Dose for Edema

Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses

Usual Adult Dose for Congestive Heart Failure

Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses

Uses:

Usual Adult Dose for Ascites

Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses

Use: Maintenance therapy together with bed rest and fluid and sodium restriction for cirrhosis of the liver accompanied by edema and/or ascites.

Usual Adult Dose for Nephrotic Syndrome

Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses

Use: For nephrotic patients when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNINGS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

General: The spironolactone content of this drug is usually sufficient to minimize potassium loss induced by the hydrochlorothiazide component; concurrent potassium supplementation is not recommended when this drug is used for the long-term management of hypertension or in the treatment of most edematous conditions.

Monitoring: Assess serum electrolytes periodically, especially in the elderly and this with significant renal or hepatic impairment.

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.