All Eyes On Ibuprofen: What You Need To Know
Medically reviewed on Mar 16, 2017 by C. Fookes, BPharm.
Cheap, Effective and Overused?
You've probably used ibuprofen yourself to reduce fever or relieve various aches and pains. Maybe you've used it when you've had a toothache, period pain, back pain or if you suffer from arthritis.
In fact, ibuprofen is so commonly used it's known as vitamin "I" in some circles. But is it genuinely harmless?
Ibuprofen Can Cause Stomach Erosions
NSAIDs block prostaglandin, a substance released by our body in response to pain that also helps protect the lining of our stomach. Without this protective barrier, stomach acids, and other irritating substances can "eat" away at the lining of our stomach, causing small erosions. Symptoms such as reflux, heartburn, or indigestion may occur. Sometimes these irritated areas worsen and form stomach ulcers.
Research has shown ibuprofen is less likely to cause stomach irritation if it is used in dosages totalling less than 1200 mg/day, and for short periods of time only. Taking ibuprofen with food can help reduce the risk as well. See your doctor before taking any NSAID if you have had stomach ulcers in the past.
Ibuprofen Thins the Blood
All NSAIDs have an effect on the blood, ibuprofen included. While not as strong as some medicines (for example, aspirin), ibuprofen still slows down blood clotting time. This means that if you cut yourself, or have an injury, it may take longer to stop bleeding.
Risk of bleeding and stomach ulceration is also increased in people who:
- Have had stomach ulcers or bleeding problems in the past
- Take prednisone or other steroids
- Smoke or drink alcohol regularly
- Take other medicines that thin the blood such as warfarin, clopidogrel (Plavix), or ticagrelor (Brilinta).
If You Have Asthma or Rhinitis Be Careful Taking Ibuprofen
NSAIDs can exacerbate symptoms of asthma or allergic rhinitis (symptoms include a stuffy, runny nose) in about 10% of people with these conditions. Within 30 to 120 minutes of taking an NSAID such as ibuprofen, nasal congestion, a runny nose or shortness of breath may occur. Some people may experience a serious asthma attack, especially if they have aspirin-sensitive asthma.
Reduced Kidney Blood Flow A Danger To Some
Ibuprofen, like other NSAIDs, reduces blood flow to the kidneys. This is not usually a problem if you are healthy and take ibuprofen at the recommended dosages for short periods of time only (like a maximum of 3 days for fever or 10 days for pain).
However, NSAID use can be a problem for people with pre-existing kidney disease or in those who are dehydrated. People with heart disease, high blood pressure, liver disease, who are over the age of 65 or who take diuretic medications like hydrochlorothiazide (HCTZ) or furosemide (Lasix) should talk with their doctor before taking NSAIDs.
Water Retention Not Good For Blood Pressure
NSAIDs can cause water retention and edema in some people. You may notice your ankles look puffy or your weight rapidly increases within a few hours of taking ibuprofen.
Having all that extra water on board can exacerbate pre-existing conditions such as high blood pressure or heart failure. It can also prevent your normal medications from working properly.
If you suffer from any medical conditions, talk with your doctor before taking ibuprofen or any NSAID. Alternative pain relievers such as acetaminophen (Tylenol) may be a better option for you.
Long-Term Use and High-Doses Are Risky to Heart Health
No drug is risk-free. However the risk of heart attack, stroke and death associated with common over-the-counter pain relievers such as ibuprofen are probably not fully appreciated by the majority of the population.
An analysis of over 200 studies involving more than 300,000 people revealed that high dose ibuprofen and other NSAIDs such as diclofenac significantly increased the risk of heart attack and possibly stroke. So for the sake of your heart, never exceed the recommended dose for ibuprofen and only take it for short periods of time.
Ibuprofen Has No Positive Effect on Sports Performance and May Cause Harm
If you compete in challenging sporting events, then chances are you've popped a few ibuprofen in your time. In fact, seven out of ten runners in the 100 mile Western States Endurance Run took them, as did 60% of Ironman competitors in Brazil. Taking NSAIDs before and during a race now seems commonplace.
But there is no proof that ibuprofen enhances athletic performance. No difference in feelings of exertion or race times were found between athletes who did or didn't take the drug. Ibuprofen users were also more likely to injure themselves, become dehydrated, or develop hyponatremia (low sodium blood levels).
Ibuprofen May Be Associated With Sexual Dysfunction and Infertility
Men who have trouble achieving or maintaining an erection or women who have difficulty conceiving should take a look at their NSAID use and speak to their doctor.
Erection problems were twice as common in men who took NSAIDs regularly compared with men who took the drugs less frequently or not at all in a 2011 Journal of Urology study. NSAID use is also associated with delayed ovulation, as reported in Drug Safety, which can lead to temporary infertility. Several studies have reported an increase in rates of conception once NSAIDs were stopped.
Do Not Take Ibuprofen During Pregnancy, Especially In the Last Trimester
Babies inside the womb get all the nutrients, blood, and oxygen they need from their mother. This means that anything the mother eats or takes, whether it be food or medicine, can potentially cross the placenta into her unborn child.
This is why NSAIDs, including ibuprofen, should not be taken by pregnant women, and the last trimester is the most critical period of all for avoiding these drugs. NSAIDs taken during this period can cause an early closing of the blood vessel that shunts blood away from the lungs in the fetus, leading to lung and heart problems in the newborn.
Finished: All Eyes On Ibuprofen: What You Need To Know
- Donnelly AE, et al. Effects of ibuprofen on exercise-induced muscle soreness and indices of muscle damage. Br J Sports Med 1990;24:191-5.
- Wharam PC, et al. NSAID use increases the risk of developing hyponatremia during an Ironman triathlon. Medicine and Science Sports and Exercise. 2006; 38: 618-22.
- Koren G, et al. Nonsteroidal antiinflammatory drugs during third trimester and the risk of premature closure of the ductus arteriosus: a meta-analysis. Ann Pharmacother. 2006;40;824-9. http://www.ncbi.nlm.nih.gov/pubmed/16638921
- Gleason JM, et al. Regular Nonsteroidal Anti-Inflammatory Drug Use and Erectile Dysfunction. J Urology 2011;185:1388-93. http://www.jurology.com/article/S0022-5347(10)05203-1/abstract
- Stone S, et al. Nonsteroidal anti-inflammatory drugs and reversible female infertility: is there a link? Drug Safety 2002;25:545-51. http://www.ncbi.nlm.nih.gov/pubmed/12113640//rheumatology.oxfordjournals.org/content/39/8/880.long