Xtandi Side Effects
Generic name: enzalutamide
Medically reviewed by Drugs.com. Last updated on Aug 30, 2021.
Note: This document contains side effect information about enzalutamide. Some of the dosage forms listed on this page may not apply to the brand name Xtandi.
Common side effects of Xtandi include: upper respiratory tract infection, headache, hot flash, laryngitis, nasopharyngitis, pharyngitis, rhinitis, and sinusitis. Other side effects include: lower respiratory tract infection, pneumonia, pulmonary infection, altered mental status, amnesia, bronchitis, cognitive dysfunction, falling, hypertension, hypoesthesia, and memory impairment. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to enzalutamide: oral capsule liquid filled, oral tablet
Side effects requiring immediate medical attention
Along with its needed effects, enzalutamide (the active ingredient contained in Xtandi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking enzalutamide:
- Back pain
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blood in the urine
- blurred vision
- chest pain
- cough with mucus
- difficulty with breathing
- loss of bladder or bowel control
- painful or difficult urination
- pounding in the ears
- slow or fast heartbeat
- sore throat
- tingling of the hands or feet
- unable to move the legs
- unusual weight gain or loss
- confusion or excitement
- loss of memory
- memory or attention span problems
- nightmares or vivid dreams
- rapid, shallow breathing
Incidence not known
- hives, itching, skin rash
- joint pain, stiffness, or swelling
- redness of the skin
- swelling of the eyelids, face, lips, hands, or feet
- tightness in the chest
- trouble breathing or swallowing
- unusual drowsiness, tiredness, weakness, or feeling of sluggishness
Side effects not requiring immediate medical attention
Some side effects of enzalutamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Body aches or pain
- bone pain
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- difficulty having a bowel movement
- difficulty with moving
- dry throat
- ear congestion
- feeling of constant movement of self or surroundings
- feeling of warmth
- lack or loss of strength
- loss of voice
- muscle pain, stiffness, or weakness
- pain or tenderness around the eyes and cheekbones
- sensation of spinning
- stuffy or runny nose
- tender, swollen glands in the neck
- trouble sleeping
For Healthcare Professionals
Applies to enzalutamide: oral capsule, oral tablet
Very common (10% or more): Headache (12%), dizziness/vertigo (11%)
Common (1% to 10%): Spinal cord compression and cauda equina syndrome, paresthesia, hypoesthesia, dysgeusia, restless legs syndrome
Uncommon (0.1% to 1%): Seizures
Postmarketing reports: Posterior reversible encephalopathy syndrome (PRES) (e.g., seizure, headache, lethargy, confusion, blindness, and other visual and neurological disturbances, with or without associated hypertension)[Ref]
Common (1% to 10%): Pruritus, dry skin
Postmarketing reports: Rash[Ref]
Common (1% to 10%): Gynecomastia[Ref]
Very common (10% or more): Constipation (23%), diarrhea (22%)
Common (1% to 10%): Hematuria, pollakiuria
Common (1% to 10%): Hematuria, pollakiuria[Ref]
Very common (10% or more): Neutropenia (15%)
Common (1% to 10%): Thrombocytopenia
Frequency not reported: Leukopenia[Ref]
Very common (10% or more): ALT elevations (10%)
Common (1% to 10%): Bilirubin elevations[Ref]
Very common (10% or more): Decreased appetite (19%), decreased weight (12%)[Ref]
Very common (10% or more): Back pain (29%), arthralgia (21%), musculoskeletal pain (15%)
Common (1% to 10%): Muscular weakness, musculoskeletal stiffness[Ref]
Very common (10% or more): Asthenia/fatigue (51%), falls (13%)
Common (1% to 10%): Fall-related injuries[Ref]
Common (1% to 10%): Lower respiratory tract and lung infection, epistaxis[Ref]
Postmarketing reports: Face edema, tongue edema, lip edema, pharynx edema[Ref]
Postmarketing reports: Blindness and other visual disturbances due to posterior reversible encephalopathy syndrome (PRES)[Ref]
Frequently asked questions
- Why has it stopped working and what do I take next?
- How long does it work for?
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- Is this a chemotherapy drug and how does it work?
- Does it lower prostate-specific antigen (PSA)?
- What is it used for?
More about Xtandi (enzalutamide)
- During Pregnancy
- Dosage Information
- Patient Tips
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 11 Reviews
- Generic Availability
- Drug class: antiandrogens
- FDA Approval History
Related treatment guides
1. "Product Information. Xtandi (enzalutamide)." Astellas Pharma US, Inc, Deerfield, IL.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.