Vanatrip Side Effects

Generic name: amitriptyline

Medically reviewed by Drugs.com. Last updated on Sep 18, 2024.

Note: This document provides detailed information about Vanatrip Side Effects associated with amitriptyline. Some dosage forms listed on this page may not apply specifically to the brand name Vanatrip.

Applies to amitriptyline: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to allow for changes in your dose and to check for any unwanted effects.

Amitriptyline may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away.

Do not take amitriptyline (the active ingredient contained in Vanatrip) if you have taken a monoamine oxidase (MAO) inhibitor (isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], or tranylcypromine [Parnate®]) in the past 2 weeks. Do not start taking a MAO inhibitor within 5 days of stopping amitriptyline. If you do, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, sudden high body temperature, extremely high blood pressure, or severe convulsions.

Do not take other medicines unless they have been discussed with your doctor. Using this medicine together with cisapride (Propulsid®), may increase the chance of having serious side effects.

Do not suddenly Stop taking amitriptyline without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a possible worsening of your condition and reduce the possibility of withdrawal symptoms such as headache, nausea, or a general feeling of discomfort or illness.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. This effect may last for a few days after you Stop taking amitriptyline. Check with your doctor before taking any of the above while you are using this medicine.

Before having any kind of surgery, tell the medical doctor in charge that you are using this medicine. Taking amitriptyline together with medicines used during surgery may increase the risk of side effects.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor.

This medicine may cause some people to become drowsy. Make sure you know how you react to this medicine before you drive, use medicines, or do anything else that could be dangerous if you are drowsy or not alert .

Serious side effects of Vanatrip

Along with its needed effects, amitriptyline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amitriptyline:

Get emergency help immediately if any of the following symptoms of overdose occur while taking amitriptyline:

Symptoms of Overdose

• clumsiness
• drowsiness
• low body temperature
• muscle aches
• muscle weakness
• sleepiness
• tiredness
• weak or feeble pulse

Other side effects of Vanatrip

Some side effects of amitriptyline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to amitriptyline: compounding powder, intramuscular solution, oral tablet.

General adverse events

The most commonly reported side effects were tremors, dizziness, headache, dry mouth, constipation, and nausea.^[Ref]

Nervous system

• Common (1% to 10%): Ataxia, disturbance in attention, dizziness, dysarthria/speech disorders, dysgeusia, drowsiness, headache, paresthesia, somnolence, tremors
• Uncommon (0.1% to 1%): Convulsions
• Very rare (less than 0.01%): Akathisia, polyneuropathy
• Frequency not reported: Abnormal voluntary movements, ageusia, alteration in cognition, alteration in electroencephalogram patterns, anticholinergic effects, autonomic nervous system function alterations, coma, disturbed concentration, extrapyramidal effects, extremity paresthesia, incoordination, neuromuscular activity alterations, numbness, peculiar taste, peripheral neuropathy, seizures, serotonin syndrome, stroke, syncope, tardive dyskinesia, tingling
• Postmarketing reports: Neuroleptic malignant syndrome^[Ref]

Cardiovascular

• Common (1% to 10%): Atrioventricular (AV) block, bundle branch block, electrocardiogram (ECG) abnormal, electrocardiogram QRS complex prolonged, electrocardiogram QT prolonged, orthostatic hypotension, palpitations, tachycardia
• Uncommon (0.1% to 1%): Collapse conditions, hypertension, worsening of cardiac failure
• Rare (0.01% to 0.1%): Arrhythmias
• Very rare (less than 0.01%): Cardiomyopathies, torsade de pointes
• Frequency not reported: Changes in AV conduction, edema, heart block, hypersensitivity myocarditis, hypotension, myocardial infarction, nonspecific ECG changes^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, diarrhea, dry mouth, nausea, tongue edema, vomiting
• Rare (0.01% to 0.1%): Paralytic ileus, salivary gland enlargement
• Frequency not reported: Black tongue, epigastric distress, parotid swelling, stomatitis^[Ref]

Respiratory

• Common (1% to 10%): Allergic inflammation of the pulmonary alveoli, allergic inflammation of the lung tissue, alveolitis, congested nose, Loffler's syndrome^[Ref]

Psychiatric

• Common (1% to 10%): Aggression, agitation, confusional states, libido decrease
• Uncommon (0.1% to 1%): Anxiety, hypomania, insomnia, mania, nightmares
• Rare (0.01% to 0.1%): Delirium (in elderly patients), hallucinations (in schizophrenic patients), suicidal behavior, suicidal thoughts
• Frequency not reported: Behavioral changes, delusions, disorientation, dream disturbances, excitement, increased libido, irritability, libido fluctuations, nightmares, paranoia, restlessness, sleep disturbances
• Postmarketing reports: Mental status changes^[Ref]

Metabolic

• Common (1% to 10%): Hyponatremia, thirst, weight increased
• Rare (0.01% to 0.1%): Blood alkaline phosphatase increased, decreased appetite, weight decreased
• Frequency not reported: Anorexia, blood sugar level elevation/lowering, increased appetite^[Ref]

Genitourinary

• Common (1% to 10%): Erectile dysfunction, micturition disorders
• Frequency not reported: Breast enlargement, dilation of urinary tract, impotence, interference with sexual function, testicular swelling, urinary frequency^[Ref]

Ocular

• Common (1% to 10%): Accommodation disorder, mydriasis
• Uncommon (0.1% to 1%): Intraocular pressure increased
• Very rare (less than 0.01%): Acute glaucoma
• Frequency not reported: Blurred vision, disturbance in accommodation, increased intraocular pressure^[Ref]

Dermatologic

• Common (1% to 10%): Hyperhidrosis
• Uncommon (0.1% to 1%): Face edema, rash/skin rash, urticaria
• Rare (0.01% to 0.1%): Alopecia, photosensitivity reaction
• Frequency not reported: Diaphoresis, increased perspiration, itching/pruritus, mild sweating, photosensitization^[Ref]

Other

• Common (1% to 10%): Fatigue
• Uncommon (0.1% to 1%): Tinnitus
• Rare (0.01% to 0.1%): Pyrexia
• Frequency not reported: Fever/hyperpyrexia, hyperthermia, malaise, weakness^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Cholestatic liver disease, hepatic impairment
• Rare (0.01% to 0.1%): Jaundice, liver function test abnormal, transaminases increased
• Frequency not reported: Altered liver function, hepatic failure, hepatitis^[Ref]

Hematologic

• Rare (0.01% to 0.1%): Agranulocytosis, bone marrow depression, eosinophilia, leukopenia, purpura, thrombocytopenia^[Ref]

Endocrine

• Rare (0.01% to 0.1%): Gynecomastia
• Frequency not reported: Syndrome of inappropriate antidiuretic hormone (SIADH) secretion^[Ref]

Immunologic

• Frequency not reported: Positive antinuclear antibodies (ANA), positive rheumatoid factor^[Ref]

Musculoskeletal

• Frequency not reported: Increased risk of bone fractures, lupus-like syndrome, migratory arthritis
• Postmarketing reports: Muscle rigidity^[Ref]

See also:

Frequently asked questions

• What are some common side effects of antidepressants?

Further information

Vanatrip side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer