Vanatrip Side Effects

Generic name: amitriptyline

Medically reviewed by Drugs.com. Last updated on Sep 18, 2024.

Note: This document provides detailed information about Vanatrip Side Effects associated with amitriptyline. Some dosage forms listed on this page may not apply specifically to the brand name Vanatrip.

Applies to amitriptyline: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders.

Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.

This risk must be balanced with the clinical need.

Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior.

Families and caregivers should be advised of the need for close observation and communication with the prescriber.

Not approved for use in pediatric patients.

Serious side effects of Vanatrip

Along with its needed effects, amitriptyline (the active ingredient contained in Vanatrip) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amitriptyline:

Incidence not known

• abdominal or stomach pain
• agitation
• black, tarry stools
• bleeding gums
• blood in urine or stools
• blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• change in consciousness
• changes in patterns and rhythms of speech
• chest pain or discomfort
• chills
• cold sweats
• coma
• confusion
• confusion about identity, place, and time
• continuing ringing, buzzing, or other unexplained noise in ears
• convulsions
• cool, pale skin
• cough or hoarseness
• dark urine
• decrease in frequency of urination
• decrease in urine volume
• decreased urine output
• difficulty in breathing
• difficulty in passing urine (dribbling)
• difficulty in speaking
• disturbance of accommodation
• disturbed concentration
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• double vision
• drooling
• dry mouth
• excitement
• fainting
• false beliefs that cannot be changed by facts
• fast, slow, or irregular heartbeat
• fear or nervousness
• fever with or without chills
• flushed, dry skin
• fruit-like breath odor
• general feeling of tiredness or weakness
• headache
• hearing loss
• high fever
• high or low blood pressure
• hostility
• inability to move arms, legs, or facial muscles
• inability to speak
• increased hunger
• increased need to urinate
• increased ocular pressure
• increased sweating
• increased thirst
• increased urination
• irritability
• lack of coordination
• lethargy
• light-colored stools
• lip smacking or puckering
• loss of appetite
• loss of balance control
• loss of bladder control
• loss of consciousness
• lower back or side pain
• mental depression or anxiety
• muscle spasm or jerking of all extremities
• muscle tightness
• muscle trembling, jerking, or stiffness
• muscle twitching
• nausea and vomiting
• nightmares or unusually vivid dreams
• overactive reflexes
• painful or difficult urination
• passing urine more often
• pinpoint red spots on skin
• poor coordination
• pounding in the ears
• puffing of cheeks
• rapid or worm-like movements of tongue
• rapid weight gain
• restlessness
• seeing, hearing, or feeling things that are not there
• seizures
• severe muscle stiffness
• shakiness and unsteady walk
• shivering
• shortness of breath
• shuffling walk
• sleeplessness
• slow speech
• slurred speech
• sore throat
• sores, ulcers, or white spots on lips or in mouth
• stiffness of limbs
• stupor
• sudden loss of consciousness
• sweating
• swelling of face, ankles, or hands
• swelling or puffiness of face
• swollen glands
• talking or acting with excitement you cannot control
• trouble in speaking
• trouble sleeping
• troubled breathing
• twisting movements of body pain or discomfort in arms, jaw, back, or neck
• unable to sleep
• uncontrolled chewing movements
• uncontrolled movements, especially of arms, face, neck, back, and legs
• unexplained weight loss
• unpleasant breath odor
• unsteadiness, trembling, or other problems with muscle control or coordination
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusually pale skin
• upper right abdominal pain
• vomiting of blood
• weakness in arms, hands, legs, or feet
• weight gain or loss
• yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking amitriptyline:

Symptoms of Overdose

• clumsiness
• drowsiness
• low body temperature
• muscle aches
• muscle weakness
• sleepiness
• tiredness
• weak or feeble pulse

Other side effects of Vanatrip

Some side effects of amitriptyline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• bigger, dilated, or enlarged pupils (black part of eye)
• black tongue
• bloating
• breast enlargement in females
• constipation
• decreased interest in sexual intercourse
• diarrhea
• hair loss, thinning of hair
• hives or welts
• inability to have or keep an erection
• increased in sexual ability, desire, drive, or performance
• increased interest in sexual intercourse
• increased sensitivity of eyes to light
• loss in sexual ability, desire, drive, or performance
• loss of sense of taste
• redness or other discoloration of skin
• severe sunburn
• skin rash
• swelling of testicles
• swelling of the breasts or breast soreness in males
• swelling of the parotid glands
• swelling or inflammation of the mouth
• unexpected or excess milk flow from breasts

For healthcare professionals

Applies to amitriptyline: compounding powder, intramuscular solution, oral tablet.

General adverse events

The most commonly reported side effects were tremors, dizziness, headache, dry mouth, constipation, and nausea.^[Ref]

Nervous system

• Common (1% to 10%): Ataxia, disturbance in attention, dizziness, dysarthria/speech disorders, dysgeusia, drowsiness, headache, paresthesia, somnolence, tremors
• Uncommon (0.1% to 1%): Convulsions
• Very rare (less than 0.01%): Akathisia, polyneuropathy
• Frequency not reported: Abnormal voluntary movements, ageusia, alteration in cognition, alteration in electroencephalogram patterns, anticholinergic effects, autonomic nervous system function alterations, coma, disturbed concentration, extrapyramidal effects, extremity paresthesia, incoordination, neuromuscular activity alterations, numbness, peculiar taste, peripheral neuropathy, seizures, serotonin syndrome, stroke, syncope, tardive dyskinesia, tingling
• Postmarketing reports: Neuroleptic malignant syndrome^[Ref]

Cardiovascular

• Common (1% to 10%): Atrioventricular (AV) block, bundle branch block, electrocardiogram (ECG) abnormal, electrocardiogram QRS complex prolonged, electrocardiogram QT prolonged, orthostatic hypotension, palpitations, tachycardia
• Uncommon (0.1% to 1%): Collapse conditions, hypertension, worsening of cardiac failure
• Rare (0.01% to 0.1%): Arrhythmias
• Very rare (less than 0.01%): Cardiomyopathies, torsade de pointes
• Frequency not reported: Changes in AV conduction, edema, heart block, hypersensitivity myocarditis, hypotension, myocardial infarction, nonspecific ECG changes^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, diarrhea, dry mouth, nausea, tongue edema, vomiting
• Rare (0.01% to 0.1%): Paralytic ileus, salivary gland enlargement
• Frequency not reported: Black tongue, epigastric distress, parotid swelling, stomatitis^[Ref]

Respiratory

• Common (1% to 10%): Allergic inflammation of the pulmonary alveoli, allergic inflammation of the lung tissue, alveolitis, congested nose, Loffler's syndrome^[Ref]

Psychiatric

• Common (1% to 10%): Aggression, agitation, confusional states, libido decrease
• Uncommon (0.1% to 1%): Anxiety, hypomania, insomnia, mania, nightmares
• Rare (0.01% to 0.1%): Delirium (in elderly patients), hallucinations (in schizophrenic patients), suicidal behavior, suicidal thoughts
• Frequency not reported: Behavioral changes, delusions, disorientation, dream disturbances, excitement, increased libido, irritability, libido fluctuations, nightmares, paranoia, restlessness, sleep disturbances
• Postmarketing reports: Mental status changes^[Ref]

Metabolic

• Common (1% to 10%): Hyponatremia, thirst, weight increased
• Rare (0.01% to 0.1%): Blood alkaline phosphatase increased, decreased appetite, weight decreased
• Frequency not reported: Anorexia, blood sugar level elevation/lowering, increased appetite^[Ref]

Genitourinary

• Common (1% to 10%): Erectile dysfunction, micturition disorders
• Frequency not reported: Breast enlargement, dilation of urinary tract, impotence, interference with sexual function, testicular swelling, urinary frequency^[Ref]

Ocular

• Common (1% to 10%): Accommodation disorder, mydriasis
• Uncommon (0.1% to 1%): Intraocular pressure increased
• Very rare (less than 0.01%): Acute glaucoma
• Frequency not reported: Blurred vision, disturbance in accommodation, increased intraocular pressure^[Ref]

Dermatologic

• Common (1% to 10%): Hyperhidrosis
• Uncommon (0.1% to 1%): Face edema, rash/skin rash, urticaria
• Rare (0.01% to 0.1%): Alopecia, photosensitivity reaction
• Frequency not reported: Diaphoresis, increased perspiration, itching/pruritus, mild sweating, photosensitization^[Ref]

Other

• Common (1% to 10%): Fatigue
• Uncommon (0.1% to 1%): Tinnitus
• Rare (0.01% to 0.1%): Pyrexia
• Frequency not reported: Fever/hyperpyrexia, hyperthermia, malaise, weakness^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Cholestatic liver disease, hepatic impairment
• Rare (0.01% to 0.1%): Jaundice, liver function test abnormal, transaminases increased
• Frequency not reported: Altered liver function, hepatic failure, hepatitis^[Ref]

Hematologic

• Rare (0.01% to 0.1%): Agranulocytosis, bone marrow depression, eosinophilia, leukopenia, purpura, thrombocytopenia^[Ref]

Endocrine

• Rare (0.01% to 0.1%): Gynecomastia
• Frequency not reported: Syndrome of inappropriate antidiuretic hormone (SIADH) secretion^[Ref]

Immunologic

• Frequency not reported: Positive antinuclear antibodies (ANA), positive rheumatoid factor^[Ref]

Musculoskeletal

• Frequency not reported: Increased risk of bone fractures, lupus-like syndrome, migratory arthritis
• Postmarketing reports: Muscle rigidity^[Ref]

Frequently asked questions

• What are some common side effects of antidepressants?

Further information

Vanatrip side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer