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Trimethobenzamide Side Effects

For the Consumer

Applies to trimethobenzamide: intramuscular solution, oral capsule

As well as its needed effects, trimethobenzamide may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking trimethobenzamide, check with your doctor immediately:

  • Body spasm, with head and heels bent backward and body bowed forward
  • convulsions (seizures)
  • depression
  • shakiness or tremors
  • skin rash
  • sore throat or fever
  • unusual tiredness
  • vomiting (severe or continuing)
  • yellow eyes or skin

Minor Side Effects

Some trimethobenzamide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Drowsiness
Less common:
  • Blurred vision
  • diarrhea
  • dizziness
  • headache
  • muscle cramps

For Healthcare Professionals

Applies to trimethobenzamide: compounding powder, intramuscular solution, oral capsule, rectal suppository

Nervous system

Frequency not reported: Parkinson-like/extrapyramidal symptoms, coma, convulsions, disorientation, dizziness, drowsiness, headache, opisthotonos[Ref]


Frequency not reported: Hypersensitivity reactions[Ref]


Frequency not reported: Hypotension[Ref]


Frequency not reported: Depression[Ref]


Frequency not reported: Diarrhea[Ref]


Frequency not reported: Jaundice[Ref]


Frequency not reported: Muscle cramps[Ref]


Frequency not reported: Blood dyscrasias[Ref]


Frequency not reported: Blurred vision[Ref]


Frequency not reported: Allergic-type skin reactions[Ref]


1. "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc, Bristol, TN.

2. "Product Information. Trimethobenzamide Hydrochloride (trimethobenzamide)." United Research Laboratories/Mutual Pharmaceutical Company, Philadelphia, PA.

It is possible that some side effects of trimethobenzamide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.