Trimethobenzamide Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 12, 2025.

Applies to trimethobenzamide: intramuscular solution.

Other dosage forms:

• oral capsule

Precautions

Trimethobenzamide will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicines for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicines or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using trimethobenzamide .

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert .

Common side effects of trimethobenzamide

Some side effects of trimethobenzamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of trimethobenzamide

Along with its needed effects, trimethobenzamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trimethobenzamide:

See also:

For healthcare professionals

Applies to trimethobenzamide: compounding powder, intramuscular solution, oral capsule, rectal suppository.

Nervous system adverse events

• Frequency not reported: Coma, convulsions, disorientation, dizziness, drowsiness, headache, opisthotonos, Parkinson-like/extrapyramidal symptoms^[Ref]

Hypersensitivity

• Frequency not reported: Allergic-type skin reactions, angioedema, hypersensitivity reactions^[Ref]

Cardiovascular

• Frequency not reported: Hypotension^[Ref]

Psychiatric

• Frequency not reported: Depression^[Ref]

Gastrointestinal

• Frequency not reported: Diarrhea^[Ref]

Hepatic

• Frequency not reported: Jaundice^[Ref]

Musculoskeletal

• Frequency not reported: Muscle cramps^[Ref]

Hematologic

• Frequency not reported: Blood dyscrasias^[Ref]

Ocular

• Frequency not reported: Blurred vision^[Ref]

Further information

Trimethobenzamide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer