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Trimethobenzamide Dosage

Applies to the following strength(s): 100 mg/mL ; 100 mg ; 250 mg ; 300 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Nausea/Vomiting

-Oral: 300 mg orally 3 or 4 times a day
-Injection: 200 mg IM 3 or 4 times a day

Comments: Dosage should be adjusted according to the therapy indication, symptom severity, and patient response.

Use: Treatment of postoperative nausea and vomiting, and nausea associated with gastroenteritis.

Usual Pediatric Dose for Nausea/Vomiting

-Oral: The manufacturer gives no specific dosing instructions; Caution recommended.
-Injection: Contraindicated

Comments: This drug should be avoided in children whose signs and symptoms could represent Reye's syndrome.

Use: Treatment of postoperative nausea and vomiting, and nausea associated with gastroenteritis.

Renal Dose Adjustments

CrCl 70 mL/min/1.73 m2 or less: Dosing modifications such as reducing the total dose at each dosing or increasing the dosing interval should be considered; Caution is recommended.

Liver Dose Adjustments

Data not available

Dose Adjustments

Discontinue treatment at the first sign of skin sensitization and if any of the following occur: blood dyscrasias, blurred vision, coma, convulsions, depression, diarrhea, disorientation, dizziness, drowsiness, headache, jaundice, muscle cramps, and opisthotonos.


Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration Advice:
-IM administration may cause pain, stinging, burning, redness, and swelling at the injection site; such effects may be minimized by deep injection into the upper outer quadrant of the gluteal region and by avoiding the escape of solution along the route.
-The injectable form is intended for IM administration only; IV use is not recommended.

Storage Requirements:
-This drug should be stored between 20 to 25 degrees Celsius (68 to 77 Fahrenheit) and protected from light.

Patient advice:
-This drug may cause drowsiness; avoid driving and potentially dangerous activities such as operating machinery until you know how this drug affects you.
-Avoid alcohol during treatment.