Medically reviewed by Drugs.com. Last updated on Dec 28, 2022.
Applies to the following strengths: 100 mg/mL; 100 mg; 250 mg; 300 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Nausea/Vomiting
Oral: 300 mg orally 3 or 4 times a day
IM Injection: 200 mg IM 3 or 4 times a day
Comment: Dosage should be adjusted according to the therapy indication, symptom severity, and patient response.
- Treatment of postoperative nausea and vomiting
- Treatment of nausea associated with gastroenteritis
Renal Dose Adjustments
Renal dysfunction (CrCl 70 mL/min/1.73 m2 or less): Dosing modifications such as reducing the total dose at each dosing or increasing the dosing interval should be considered; Caution is recommended.
Liver Dose Adjustments
- Patients with signs/symptoms suggested of liver dysfunction: Avoid use
- Patients who develop liver dysfunction during treatment: Discontinue use.
IM Injection Formulations: Data not available
Geriatric patients: The daily dosage should be reduced by increasing the dosing interval, then adjust as needed based on therapeutic response and tolerability. Renal function should be monitored.
Discontinue treatment at the first sign of skin sensitization and if any of the following occur: blood dyscrasias, blurred vision, coma, convulsions, depression, diarrhea, disorientation, dizziness, drowsiness, headache, jaundice, muscle cramps, and opisthotonos.
Safety and efficacy have not been established in patients younger than 18 years.
This drug is not recommended for use in children.
Consult WARNINGS section for additional precautions.
Data not available
- IM administration may cause pain, stinging, burning, redness, and swelling at the injection site; such effects may be minimized by deep injection into the upper outer quadrant of the gluteal region and by avoiding the escape of solution along the route.
- The injectable form is intended for IM administration only; IV use is not recommended.
- This drug should be stored between 20 to 25 degrees Celsius (68 to 77 Fahrenheit) and protected from light.
- Limitation of use: This drug is not recommended for use in pediatric patients.
- This drug may cause drowsiness; patients should be told to avoid driving and potentially dangerous activities such as operating machinery until they know how this drug affects them.
- Patients should be instructed to avoid alcohol and other drugs that cause central nervous system depression during treatment.
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