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Trimethobenzamide Pregnancy and Breastfeeding Warnings

Trimethobenzamide is also known as: Benzacot, Ticon, Tigan

Trimethobenzamide Pregnancy Warnings

Safety in pregnancy has not been established. US FDA pregnancy category: Not formally assigned to a pregnancy category. Comments: It is unknown if this drug crosses the placenta, but its molecular weight (about 389 for the free base) suggests that exposure to the embryo-fetus should be expected.

Some data show no adverse effects in fetuses when this drug was used in pregnancy to treat nausea and vomiting. However, a study of 193 pregnant patients treated with this drug in the 1st trimester showed incidences of severe congenital defects at 1 month (2.6%), 1 year (2.6%), and 5 years (5.8%); the study authors determined that there is a low risk of congenital malformations since other factors (including the use of other antiemetics in some patients) may have contributed to the results. Animal studies failed to reveal any evidence of teratogenicity. Increased resorptions and stillborn pups were observed, but these adverse effects occurred in only 1 to 2 dams in each study.

See references

Trimethobenzamide Breastfeeding Warnings

Safety in nursing mothers has not been established. Excreted into human milk: Unknown Excreted into animal milk: Data not available Comments: The drug molecular weight (about 389 for the free base) is low enough that excretion into breast milk should be expected; the effects in the nursing infant are unknown.

See references

References for pregnancy information

  1. "Product Information. Trimethobenzamide Hydrochloride (trimethobenzamide)." United Research Laboratories/Mutual Pharmaceutical Company, Philadelphia, PA.
  2. Briggs GG, Freeman RK, Yaffe SJ. "Drugs in Pregnancy and Lactation. 9th ed." Philadelphia, PA: Llippincott Williams & Wilkins (2011):
  3. "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc, Bristol, TN.

References for breastfeeding information

  1. "Product Information. Trimethobenzamide Hydrochloride (trimethobenzamide)." United Research Laboratories/Mutual Pharmaceutical Company, Philadelphia, PA.
  2. "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc, Bristol, TN.
  3. Briggs GG, Freeman RK, Yaffe SJ. "Drugs in Pregnancy and Lactation. 9th ed." Philadelphia, PA: Llippincott Williams & Wilkins (2011):

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