Trelegy Ellipta Side Effects

Generic name: fluticasone / umeclidinium / vilanterol

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jan 10, 2025.

Note: This document provides detailed information about Trelegy Ellipta Side Effects associated with fluticasone / umeclidinium / vilanterol. Some dosage forms listed on this page may not apply specifically to the brand name Trelegy Ellipta.

Applies to fluticasone / umeclidinium / vilanterol: inhalation powder.

Serious side effects of Trelegy Ellipta

Along with its needed effects, fluticasone/umeclidinium/vilanterol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluticasone/umeclidinium/vilanterol:

Less common side effects

• bladder pain
• bloody or cloudy urine
• chest pain or tightness
• chills
• cough
• diarrhea
• difficult, burning, or painful urination
• fever
• frequent urge to urinate
• headache
• loss of appetite
• lower back or side pain
• nausea
• pain in the nose and mouth
• pain or tenderness around the eyes and cheekbones
• sneezing
• sore throat
• stuffy or runny nose
• stomach pain
• trouble breathing
• weakness

Incidence not known

• difficulty swallowing
• dizziness
• fast heartbeat
• hives, itching, skin rash
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
• puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
• redness of the skin
• unusual tiredness or weakness

Other side effects of Trelegy Ellipta

Some side effects of fluticasone / umeclidinium / vilanterol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• back pain
• change in taste
• headache
• loss of taste

For healthcare professionals

Applies to fluticasone / umeclidinium / vilanterol: inhalation powder.

Gastrointestinal adverse events

• Common (1% to 10%): Oropharyngeal pain, diarrhea, gastroenteritis^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain^[Ref]

Respiratory

• Common (1% to 10%): Cough^[Ref]

Nervous system

• Common (1% to 10%): Headache, dysgeusia^[Ref]

Frequently asked questions

• What are some alternatives for Trelegy Ellipta?
• Can asthma inhalers cause a sore throat?
• What is the difference between Breztri vs Trelegy?
• How long does it take for Trelegy to work?
• Trelegy vs. Breo: How does their use and cost compare?
• What is the best time of day to take Trelegy?
• Trelegy vs Anoro: Which is better?
• Can you take Trelegy and Symbicort together?
• Can Trelegy Ellipta cause weight gain?

Further information

Trelegy Ellipta side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer