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Trelegy Ellipta Side Effects

Generic name: fluticasone / umeclidinium / vilanterol

Medically reviewed by Philip Thornton, DipPharm. Last updated on Aug 19, 2023.

Note: This document contains side effect information about fluticasone / umeclidinium / vilanterol. Some dosage forms listed on this page may not apply to the brand name Trelegy Ellipta.

Applies to fluticasone / umeclidinium / vilanterol: inhalation powder.

Serious side effects of Trelegy Ellipta

Along with its needed effects, fluticasone/umeclidinium/vilanterol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluticasone/umeclidinium/vilanterol:

Less common

Incidence not known

Other side effects of Trelegy Ellipta

Some side effects of fluticasone / umeclidinium / vilanterol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to fluticasone / umeclidinium / vilanterol: inhalation powder.


Common (1% to 10%): Oropharyngeal pain, diarrhea, gastroenteritis[Ref]


Common (1% to 10%): Back pain[Ref]


Common (1% to 10%): Cough[Ref]

Nervous system

Common (1% to 10%): Headache, dysgeusia[Ref]

Frequently asked questions


1. Product Information. Trelegy Ellipta (fluticasone / umeclidinium / vilanterol). GlaxoSmithKline. 2017.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.