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Treanda Side Effects

Generic Name: bendamustine

Note: This page contains side effects data for the generic drug bendamustine. It is possible that some of the dosage forms included below may not apply to the brand name Treanda.

For the Consumer

Applies to bendamustine: intravenous powder for solution, intravenous solution

As well as its needed effects, bendamustine (the active ingredient contained in Treanda) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking bendamustine, check with your doctor or nurse immediately:

More common:
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • chest pain
  • chills
  • cough or hoarseness
  • diarrhea
  • fever
  • headache
  • joint pain, stiffness, or swelling
  • lack or loss of strength
  • lower back, side, or stomach pain
  • muscle aches
  • nausea
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sore throat
  • stuffy or runny nose
  • swelling of the feet or lower legs
  • swollen glands
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
Less common:
  • Burning or stinging of the skin
  • fast heartbeat
  • hives
  • itching
  • irritation
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • rash
  • redness of the skin
  • stiffness or swelling
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
Incidence not known:
  • Blistering, flaking, or peeling of the skin
  • bluish color
  • changes in skin color
  • dizziness
  • pain, tenderness, or swelling of the foot or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • weakness

Minor Side Effects

Some bendamustine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Decreased weight

For Healthcare Professionals

Applies to bendamustine: intravenous powder for injection, intravenous solution


Very common (10% or more): Decreased lymphocytes (up to 99%), decreased leukocytes (up to 94%), decreased hemoglobin (up to 89%), decreased neutrophils (up to 86%), decreased platelets (up to 86%), lymphocytopenia (up to 74%), neutropenia (up to 45%), thrombocytopenia (up to 39%), anemia (up to 38%), leukopenia (up to 37%)
Common (1% to 10%): Febrile neutropenia, hemorrhage, lymphopenia
Very rare (less than 0.01%): Hemolysis
Postmarketing reports: Pancytopenia[Ref]


Very common (10% or more): Nausea (up to 77%), diarrhea (up to 42%), vomiting (up to 40%), constipation (up to 31%), stomatitis (up to 21%), abdominal pain (up to 14%), dyspepsia (up to 14%), gastroesophageal reflux disease (up to 11%)
Common (1% to 10%): Dry mouth, upper abdominal pain, abdominal distension, oral candidiasis
Very rare (less than 0.01%): Gastrointestinal hemorrhage, hemorrhagic esophagitis[Ref]


Very common (10% or more): Fatigue (up to 64%), infectious episodes (up to 37%), pyrexia (up to 36%), chills (up to 14%), asthenia (up to 13%), herpes zoster (up to 12%), mucosal inflammation
Common (1% to 10%): Pain, infection, herpes simplex, amenorrhea, epididymitis, thirst, cytomegalovirus infection
Uncommon (0.1% to 1%): Sepsis
Very rare (less than 0.01%): Infertility, multi-organ failure
Frequency not reported: Septic shock, general physical health deterioration[Ref]


Very common (10% or more): Elevated bilirubin (up to 34%), increased creatinine, increased urea
Common (1% to 10%): Increased AST, increased ALT, increased alkaline phosphatase
Frequency not reported: Hepatitis, hepatic failure, gallbladder pain[Ref]


Very common (10% or more): Anorexia (up to 24%), decreased weight (up to 20%), dehydration (up to 15%), decreased appetite (up to 13%), hypokalemia (up to 11%)
Common (1% to 10%): Hyperuricemia, tumor lysis syndrome, hypomagnesemia[Ref]


Very common (10% or more): Cough (up to 22%), dyspnea (up to 17%), upper respiratory tract infection (up to 10%), pharyngolaryngeal pain (up to 10%)
Common (1% to 10%): Nasopharyngitis, sinusitis, pneumonia, wheezing, nasal congestion, pulmonary dysfunction
Very rare (less than 0.01%): Pulmonary fibrosis
Frequency not reported: Lung neoplasm, lung infiltration, pleural effusion
Postmarketing reports: Pneumocystis jiroveci pneumonia, pneumonitis[Ref]

Nervous system

Very common (10% or more): Headache (up to 21%), dizziness (up to 15%), dysgeusia (up to 11%)
Rare (less than 0.1%): Somnolence, aphonia
Very rare (less than 0.01%): Paresthesia, peripheral sensory neuropathy, anticholinergic syndrome, neurological disorders, ataxia, encephalitis
Frequency not reported: Paraplegia, neuralgia[Ref]


Very common (10% or more): Rash (up to 16%), erythema (up to 16%), skin allergic reactions (up to 15%)
Common (1% to 10%): Pruritus, dry skin, night sweats, hyperhidrosis, alopecia, skin disorders
Rare (less than 0.1%): Dermatitis, macular-papular rash
Frequency not reported: Toxic skin reactions, bullous exanthema, urticaria
Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]


Very common (10% or more): Insomnia (up to 15%)
Common (1% to 10%): Anxiety, depression[Ref]


Very common (10% or more): Peripheral edema (up to 14%)
Common (1% to 10%): Tachycardia, chest pain, hypotension, cardiac dysfunction (palpitations, angina pectoris, arrhythmia), hypertension
Uncommon (0.1% to 1%): Pericardial effusion
Rare (less than 0.1%): Myocardial infarction, acute circulatory failure, cardiac failure
Very rare (less than 0.01%): Phlebitis
Frequency not reported: Vasculitis
Postmarketing reports: Atrial fibrillation, congestive heart failure[Ref]


Very common (10% or more): Back pain (up to 14%)
Common (1% to 10%): Arthralgia, extremity pain, bone pain, myalgia
Frequency not reported: Sacral pain[Ref]


Very common (10% or more): Urinary tract infection (up to 11%)[Ref]


Common (1% to 10%): Hypersensitivity reactions
Rare (less than 0.1%): Anaphylaxis, anaphylactoid reaction
Very rare (less than 0.01%): Anaphylactic shock[Ref]


Common (1% to 10%): Infusion site pain, catheter site pain
Frequency not reported: Extravasation injury, infusion reactions, injection site reactions[Ref]


Frequency not reported: Retinal detachment[Ref]


Frequency not reported: Pre-malignant and malignant diseases/secondary tumors[Ref]


Frequency not reported: Acute renal failure[Ref]


1. "Product Information. Bendeka (bendamustine)." Teva Pharmaceuticals USA, North Wales, PA.

2. "Product Information. Treanda (bendamustine)." Cephalon Inc, West Chester, PA.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of Treanda may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.