Generic Name: obinutuzumab (OH bi nue TOOZ ue mab)
Brand Names: Gazyva
What is Gazyva?
Gazyva (obinutuzumab) is a monoclonal antibody that affects the actions of the body's immune system. Obinutuzumab strengthens your immune system to help your body fight against tumor cells.
After completing combination chemotherapy, some people with advanced follicular lymphoma continue using Gazyva by itself to help delay the progression of this disease.
If you have ever had hepatitis B, Gazyva can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function during treatment and for several months after you stop using this medicine.
Gazyva may cause a serious viral infection of the brain that can lead to disability or death. Call your doctor right away if you have any change in your mental state, decreased vision, or problems with speech or walking.
Before taking this medicine
You should not receive Gazyva if you have ever had a severe allergic reaction to obinutuzumab, including a condition called serum sickness.
To make sure Gazyva is safe for you, tell your doctor if you have:
hepatitis B or other liver problems;
an active or recent infection;
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
It is not known whether Gazyva will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether obinutuzumab passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
How is Gazyva given?
Gazyva is injected into a vein through an IV. A healthcare provider will give you this injection. You will receive this medicine in a hospital or infusion clinic.
Gazyva is given in a 28-day treatment cycle, and you may only need to receive the medicine only on certain days of each cycle. Your doctor will determine how long to treat you with Gazyva.
On the days you receive this medicine, plan to spend most of the day at the hospital or infusion clinic.
You may be given other medications to help prevent serious side effects or allergic reaction. Keep using these medicines for as long as your doctor has prescribed.
Obinutuzumab can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
If you have ever had hepatitis B, obinutuzumab can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function during treatment and for several months after you stop using this medicine.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Gazyva injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving Gazyva?
Do not receive a "live" vaccine while receiving Gazyva. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Gazyva side effects
Get emergency medical help if you have signs of an allergic reaction to Gazyva: hives, rash or itching; fever, swollen glands, joint pain; fast heartbeats, chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.
Obinutuzumab may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have any mood or behavior changes, confusion, memory problems, decreased vision, weakness on one side of your body, or problems with speech or walking. These symptoms may start gradually and get worse quickly.
Some side effects may occur during the injection, or within 24 hours afterward. Tell your caregiver right away if you feel tired, feverish, chilled, sweaty, itchy, tingly, light-headed, nauseated, or if you have a headache, vomiting, diarrhea, chest pain, fast heartbeats, wheezing, trouble breathing, or throat irritation.
Tell your caregiver right away if you have:
pain or burning when you urinate;
fever, chills, cough with yellow or green mucus;
stabbing chest pain, wheezing, feeling short of breath;
confusion, vision problems, problems with speech or walking;
low blood cell counts - fever, chills, tiredness, flu-like symptoms, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or
signs of tumor cell breakdown - muscle cramps, tiredness, confusion, fast or slow heart rate, fluttering in your chest, vomiting, diarrhea, decreased urination, tingling in your hands or feet, tingling around your mouth.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common Gazyva side effects may include:
fever, weakness, loss of appetite;
low blood cell counts;
headache, joint pain;
cough, runny or stuffy nose, sinus pain; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Gazyva?
Make sure your doctor knows if you take blood pressure medication, or if you take a blood thinner or other medicine to prevent blood clots. You may need to stop taking these medications for a short time before and during treatment with Gazyva. Do not change your doses or medication schedule without your doctor's advice.
Other drugs may interact with obinutuzumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
More about Gazyva (obinutuzumab)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: CD20 monoclonal antibodies
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Gazyva.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Gazyva only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2018 Cerner Multum, Inc. Version: 3.01.
Date modified: January 30, 2018
Last reviewed: November 28, 2017