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Obinutuzumab use while Breastfeeding

Drugs containing Obinutuzumab: Gazyva

Medically reviewed by Drugs.com. Last updated on Nov 20, 2020.

Obinutuzumab Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the clinical use of obinutuzumab during breastfeeding. Because obinutuzumab is a large protein molecule with a molecular weight of about 150,000 Da, the amount in milk is likely to be very low. It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal. Until more data become available, obinutuzumab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.[1] The manufacturer recommends that breastfeeding be discontinued during obinutuzumab therapy and for 6 months after the last dose.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Pistilli B, Bellettini G, Giovannetti E, et al. Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about breastfeeding? Cancer Treat Rev. 2013;39:207–11. [PubMed: 23199900]

Substance Identification

Substance Name

Obinutuzumab

CAS Registry Number

949142-50-1

Drug Class

Breast Feeding

Lactation

Antibodies, Monoclonal

Antineoplastic Agents

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Further information

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