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Trandolapril / verapamil Side Effects

In Summary

Commonly reported side effects of trandolapril/verapamil include: sinus bradycardia. Other side effects include: bradycardia, first degree atrioventricular block, and second degree atrioventricular block. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trandolapril / verapamil: oral tablet extended release

As well as its needed effects, trandolapril / verapamil may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking trandolapril / verapamil, check with your doctor immediately:

  • Chest pain
  • chills
  • cough (with mucus)
  • dark urine
  • fever
  • general feeling of discomfort or illness
  • lightheadedness or fainting
  • pain in the right side of the abdomen or stomach
  • shortness of breath
  • slow heartbeat
  • sore throat
  • swelling of the face, mouth, hands, or feet
  • trouble in swallowing or breathing (sudden) accompanied by hoarseness
  • wheezing
  • yellow eyes or skin

Minor Side Effects

Some trandolapril / verapamil side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common or rare:
  • Constipation
  • cough (dry, continuing)
  • diarrhea
  • dizziness
  • itching
  • joint pain or pain in the arms or legs
  • nausea
  • unusual tiredness

For Healthcare Professionals

Applies to trandolapril / verapamil: oral tablet extended release


The most common adverse reactions were headache, upper respiratory tract infection, cough, atrioventricular block first degree, constipation, and dizziness.[Ref]


Common (1% to 10%): Upper respiratory tract infection, cough, dyspnea, bronchitis, upper respiratory tract congestion
Frequency not reported: Epistaxis

Frequency not reported: Pulmonary edema[Ref]


Common (1% to 10%): Asthenia/weakness, chest pain, edema, fatigue
Frequency not reported: Malaise

Frequency not reported: Gynecomastia[Ref]


Common (1% to 10%): Constipation, nausea, diarrhea
Frequency not reported: Dyspepsia, dry mouth

Frequency not reported: Pancreatitis

Frequency not reported: Gingival hyperplasia, reversible nonobstructive paralytic ileus[Ref]


Common (1% to 10%): Pain back, pain extremity, pain joint
Frequency not reported: Arthralgias/myalgias[Ref]


Common (1% to 10%): Atrioventricular (AV) block first degree, bradycardia
Uncommon (0.1% to 1%): Hypotension
Frequency not reported: Angina, AV block second degree, bundle branch block, flushing, myocardial infarction, palpitation, premature ventricular contraction, nonspecific ST-T changes, tachycardia

Frequency not reported: Congestive heart failure, AV block third degree, AV dissociation, claudication, vasculitis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Near syncope
Frequency not reported: Drowsiness, hypesthesia, loss of balance, paresthesia, vertigo, tinnitus

Frequency not reported: Syncope, cerebrovascular accident, shakiness, somnolence
Postmarketing reports: Tetraparesis[Ref]

There has been one postmarketing report of paralysis (tetraparesis) with verapamil, which may have been caused by concomitant use of colchicine.[Ref]


Common (1% to 10%): Creatinine increased
Uncommon (0.1% to 1%): BUN increased[Ref]


Common (1% to 10%): Hyperlipidemia
Frequency not reported: Gout, uric acid increased, hyperkalemia, hyponatremia[Ref]


Common (1% to 10%): Liver enzymes increased
Frequency not reported: Serum bilirubin increased[Ref]


Common (1% to 10%): Influenza[Ref]


Uncommon (0.1% to 1%): Angioedema
Frequency not reported: Pruritus, rash

Frequency not reported: Purpura, ecchymosis, exanthema, hair loss, hyperkeratosis, maculae, Stevens-Johnson syndrome, erythema multiform[Ref]


Frequency not reported: Impotence, endometriosis, hematuria, nocturia, polyuria, proteinuria

Frequency not reported: Urination increased, menstruation spotty[Ref]


Frequency not reported: Leukocytes decreased, neutrophils decreased, white blood cells low, neutrophils low, lymphocytes low, platelets low[Ref]


Frequency not reported: Insomnia, anxiety, mentation abnormal

Frequency not reported: Libido decreased

Frequency not reported: Confusion, psychotic symptoms[Ref]


Frequency not reported: Vision blurred[Ref]


Frequency not reported: Galactorrhea/hyperprolactinemia[Ref]


1. "Product Information. Tarka (trandolapril-verapamil)." Knoll Pharmaceutical Company, Whippany, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of trandolapril / verapamil may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.