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Trandolapril / verapamil Side Effects

In Summary

Commonly reported side effects of trandolapril/verapamil include: sinus bradycardia. Other side effects include: bradycardia, first degree atrioventricular block, and second degree atrioventricular block. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trandolapril / verapamil: oral tablet extended release

As well as its needed effects, trandolapril / verapamil may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking trandolapril / verapamil, check with your doctor immediately:

Rare
  • Chest pain
  • chills
  • cough (with mucus)
  • dark urine
  • fever
  • general feeling of discomfort or illness
  • lightheadedness or fainting
  • pain in the right side of the abdomen or stomach
  • shortness of breath
  • slow heartbeat
  • sore throat
  • swelling of the face, mouth, hands, or feet
  • trouble in swallowing or breathing (sudden) accompanied by hoarseness
  • wheezing
  • yellow eyes or skin

Minor Side Effects

Some trandolapril / verapamil side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common or rare:
  • Constipation
  • cough (dry, continuing)
  • diarrhea
  • dizziness
  • itching
  • joint pain or pain in the arms or legs
  • nausea
  • unusual tiredness

For Healthcare Professionals

Applies to trandolapril / verapamil: oral tablet extended release

General

The most common adverse reactions were headache, upper respiratory tract infection, cough, atrioventricular block first degree, constipation, and dizziness.[Ref]

Respiratory

Common (1% to 10%): Upper respiratory tract infection, cough, dyspnea, bronchitis, upper respiratory tract congestion
Frequency not reported: Epistaxis

Verapamil:
Frequency not reported: Pulmonary edema[Ref]

Other

Common (1% to 10%): Asthenia/weakness, chest pain, edema, fatigue
Frequency not reported: Malaise

Verapamil:
Frequency not reported: Gynecomastia[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, nausea, diarrhea
Frequency not reported: Dyspepsia, dry mouth

Trandolapril:
Frequency not reported: Pancreatitis

Verapamil:
Frequency not reported: Gingival hyperplasia, reversible nonobstructive paralytic ileus[Ref]

Musculoskeletal

Common (1% to 10%): Pain back, pain extremity, pain joint
Frequency not reported: Arthralgias/myalgias[Ref]

Cardiovascular

Common (1% to 10%): Atrioventricular (AV) block first degree, bradycardia
Uncommon (0.1% to 1%): Hypotension
Frequency not reported: Angina, AV block second degree, bundle branch block, flushing, myocardial infarction, palpitation, premature ventricular contraction, nonspecific ST-T changes, tachycardia

Verapamil:
Frequency not reported: Congestive heart failure, AV block third degree, AV dissociation, claudication, vasculitis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Near syncope
Frequency not reported: Drowsiness, hypesthesia, loss of balance, paresthesia, vertigo, tinnitus

Verapamil:
Frequency not reported: Syncope, cerebrovascular accident, shakiness, somnolence
Postmarketing reports: Tetraparesis[Ref]

There has been one postmarketing report of paralysis (tetraparesis) with verapamil, which may have been caused by concomitant use of colchicine.[Ref]

Renal

Common (1% to 10%): Creatinine increased
Uncommon (0.1% to 1%): BUN increased[Ref]

Metabolic

Common (1% to 10%): Hyperlipidemia
Frequency not reported: Gout, uric acid increased, hyperkalemia, hyponatremia[Ref]

Hepatic

Common (1% to 10%): Liver enzymes increased
Frequency not reported: Serum bilirubin increased[Ref]

Immunologic

Common (1% to 10%): Influenza[Ref]

Dermatologic

Uncommon (0.1% to 1%): Angioedema
Frequency not reported: Pruritus, rash

Verapamil:
Frequency not reported: Purpura, ecchymosis, exanthema, hair loss, hyperkeratosis, maculae, Stevens-Johnson syndrome, erythema multiform[Ref]

Genitourinary

Frequency not reported: Impotence, endometriosis, hematuria, nocturia, polyuria, proteinuria

Verapamil:
Frequency not reported: Urination increased, menstruation spotty[Ref]

Hematologic

Frequency not reported: Leukocytes decreased, neutrophils decreased, white blood cells low, neutrophils low, lymphocytes low, platelets low[Ref]

Psychiatric

Frequency not reported: Insomnia, anxiety, mentation abnormal

Trandolapril:
Frequency not reported: Libido decreased

Verapamil:
Frequency not reported: Confusion, psychotic symptoms[Ref]

Ocular

Frequency not reported: Vision blurred[Ref]

Endocrine

Verapamil:
Frequency not reported: Galactorrhea/hyperprolactinemia[Ref]

References

1. "Product Information. Tarka (trandolapril-verapamil)." Knoll Pharmaceutical Company, Whippany, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of trandolapril / verapamil may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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