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Trandolapril / Verapamil Side Effects

Medically reviewed by Drugs.com. Last updated on Feb 7, 2024.

Applies to trandolapril / verapamil: oral tablet extended release.

Important warnings This medicine can cause some serious health issues

Oral route (tablet, extended release)

Discontinue treatment with trandolapril/verapamil hydrochloride as soon as possible when pregnancy is detected, since fetal toxicity, including injury and death to the developing fetus, can be caused by drugs that act directly on the renin-angiotensin system.

Serious side effects

Along with its needed effects, trandolapril / verapamil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trandolapril / verapamil:

Rare side effects

  • chest pain
  • chills
  • cough (with mucus)
  • dark urine
  • fever
  • general feeling of discomfort or illness
  • lightheadedness or fainting
  • pain in the right side of the abdomen or stomach
  • slow heartbeat
  • sore throat
  • swelling of the face, mouth, hands, or feet
  • trouble in swallowing or breathing (sudden) accompanied by hoarseness
  • yellow eyes or skin

Other side effects

Some side effects of trandolapril / verapamil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare side effects

  • constipation
  • cough (dry, continuous)
  • diarrhea
  • dizziness
  • itching
  • joint pain or pain in the arms or legs
  • nausea
  • unusual tiredness

For healthcare professionals

Applies to trandolapril / verapamil: oral tablet extended release.

General adverse events

The most common adverse reactions were headache, upper respiratory tract infection, cough, atrioventricular block first degree, constipation, and dizziness.[Ref]

Respiratory

Verapamil:

Other

Verapamil:

Gastrointestinal

Trandolapril:

Verapamil:

Musculoskeletal

Cardiovascular

Verapamil:

Nervous system

Verapamil:

There has been one postmarketing report of paralysis (tetraparesis) with verapamil, which may have been caused by concomitant use of colchicine.[Ref]

Renal

Metabolic

Hepatic

Immunologic

Dermatologic

Verapamil:

Genitourinary

Verapamil:

Hematologic

Psychiatric

Trandolapril:

Verapamil:

Ocular

Endocrine

Verapamil:

References

1. (2001) "Product Information. Tarka (trandolapril-verapamil)." Knoll Pharmaceutical Company

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Trandolapril/verapamil side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.