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Trandolapril / Verapamil Dosage

Applies to the following strength(s): 1 mg-240 mg ; 2 mg-180 mg ; 2 mg-240 mg ; 4 mg-240 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose should be based on the patient's requirements for each drug.

Comments: The usual recommended dose ranges for hypertension are 1 to 4 mg per day (trandolapril) and 120 to 480 mg per day (verapamil sustained-release), each in 1 or 2 divided doses.

Renal Dose Adjustments

Dose adjustment recommended; however, no specific guidelines have been suggested.

Liver Dose Adjustments

Dose adjustment may be required; however, no specific guidelines have been suggested. Caution recommended.

If jaundice or marked elevation of hepatic enzymes occurs: Discontinue this drug and seek medical attention.

Precautions

US BOXED WARNING:
-FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. Drugs that act directly on the renin angiotensin system (RAS) can cause injury and death to the developing fetus.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice: Take with food.

Monitoring:
-Cardiovascular: PR interval
-Hepatic: Liver function periodically
-Renal: Kidney function periodically
-Hematologic: Consider periodic WBC monitoring in patients with collagen-vascular disease and/or renal disease.

Patient advice:
-Female patients of childbearing age should be told about the consequences of exposure to this drug during pregnancy. Patients should be asked to report pregnancies as soon as possible.
-Advise patients to report any signs of infection (e.g., sore throat, fever). If infection is suspected, WBCs should be performed immediately.
-Advise patients to use caution when driving or operating machinery until the response to initial treatment has been determined.

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