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Telavancin Side Effects

In Summary

Commonly reported side effects of telavancin include: increased serum creatinine. Other side effects include: pruritus and skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to telavancin: intravenous powder for solution

Along with its needed effects, telavancin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking telavancin:

Less common
  • Blood in the urine
  • change in the frequency of urination or amount of urine
  • difficulty with breathing
  • drowsiness
  • increased thirst
  • loss of appetite
  • nausea or vomiting
  • swelling of the feet or lower legs
  • weakness
Incidence not known
  • Abdominal or stomach tenderness
  • chills or fever
  • cough
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness, especially when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • hives or itching of the skin
  • nausea or vomiting
  • pain, redness, or soreness at the injection site
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash or redness of the face, base of the neck, upper body, back, and arms
  • severe abdominal or stomach cramps and pain
  • tightness in the chest
  • unusual tiredness or weakness
  • watery and severe diarrhea, which may also be bloody

Some side effects of telavancin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bad, unusual or unpleasant (after) taste
  • change in taste
  • diarrhea
  • foamy urine
Less common
  • Decreased appetite
  • dry, red, hot, or irritated skin
  • feeling unusually cold
  • shivering

For Healthcare Professionals

Applies to telavancin: intravenous powder for injection


Very common (10% or more): All-cause mortality (up to 44%)
Common (1% to 10%): Fungal infection, fatigue, chills
Uncommon (0.1% to 1%): Septic shock, multi-organ failure, tinnitus, asthenia, malaise, non-cardiac chest pain, peripheral edema, pain, pyrexia, infusion site reactions including Red Man syndrome
Rare (less than 0.1%): Deafness[Ref]


Very common (10% or more): Increased serum creatinine to 1.5 times baseline (up to 16%), renal impairment/renal insufficiency/renal failure (up to 10%)
Common (1% to 10%): Acute renal failure, increased blood creatinine
Uncommon (0.1% to 1%): Increased blood urea[Ref]


Uncommon (0.1% to 1%): Anemia, leukopenia, thrombocythemia, thrombocytopenia, increased eosinophil count, increased neutrophil count, increased INR


Common (1% to 10%): QTc prolongation
Uncommon (0.1% to 1%): Angina pectoris, atrial fibrillation, bradycardia, congestive cardiac failure, prolonged electrocardiogram QT corrected interval, palpitations, sinus tachycardia, supraventricular extrasystoles, ventricular extrasystoles, flushing, hypertension, hypotension, phlebitis[Ref]


Very common (10% or more): Nausea (up to 27%), vomiting (up to 14%)
Common (1% to 10%): Diarrhea, constipation
Uncommon (0.1% to 1%): Clostridium colitis, abdominal pain, dry mouth, dyspepsia, flatulence, oral hypoesthesia[Ref]


Uncommon (0.1% to 1%): Hypersensitivity reactions
Postmarketing reports: Anaphylaxis[Ref]

Nervous system

Very common (10% or more): Metallic/soapy taste disturbance (up to 33%), dysgeusia (more than 10%)
Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Ageusia, migraine, paraesthesia, parosmia, somnolence, tremor[Ref]


Very common (10% or more): Foamy urine (up to 13%)
Uncommon (0.1% to 1%): Urinary tract infection, dysuria, hematuria, microalbuminuria, oliguria, pollakiuria, abnormal urine odor


Common (1% to 10%): Increased ALT, increased AST
Uncommon (0.1% to 1%): Hepatitis


Common (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Erythema, face edema, hyperhidrosis, urticaria[Ref]


Common (1% to 10%): Decreased appetite
Uncommon (0.1% to 1%): Hyperglycemia, hyperkalemia, hypoglycemia, hypokalemia, hypomagnesemia[Ref]


Common (1% to 10%): Rigors
Uncommon (0.1% to 1%): Arthralgia, back pain, muscle cramp, myalgia


Uncommon (0.1% to 1%): Eye irritation, blurred vision


Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Agitation, anxiety, confusional state, depression


Uncommon (0.1% to 1%): Dyspnea, hiccups, nasal congestion, pharyngolaryngeal pain


1. "Product Information. Vibativ (telavancin)." Theravance Inc, South San Francisco, CA.

Some side effects of telavancin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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