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Generic Name: telavancin (TEL a VAN sin)
Brand Names: Vibativ

Medically reviewed on January 29, 2018

What is Vibativ?

Vibativ (telavancin) is an antibiotic that fights bacteria.

Vibativ is used to treat severe skin infections. It is also used to treat pneumonia caused by bacteria in a hospital setting, or pneumonia that can develop while using a ventilator (artificial breathing machine).

Vibativ may also be used for purposes not listed in this medication guide.

Important information

You may not be able to use Vibativ if you are pregnant. In animal studies, telavancin caused birth defects. You may need to have a negative pregnancy test before starting this treatment.

To make sure Vibativ is safe for you, tell your doctor if you have a history of kidney problems. Your kidney function will need to be checked while your are receiving this medicine. Call your doctor at once if you have signs of kidney problems: little or no urinating, swelling in your ankles or feet, weight gain, or urine that looks foamy.

Call your doctor right away if you have a serious side effect such as watery or bloody diarrhea, confusion, thirst, swelling, or feeling short of breath.

Before receiving Vibativ

You should not use Vibativ if you are allergic to telavancin, or if you are also using a certain type of heparin.

To make sure Vibativ is safe for you, tell your doctor if you have:

  • a history of kidney problems;

  • diabetes;

  • heart disease, high blood pressure;

  • heart rhythm disorder, or history of Long QT syndrome; or

  • if you are allergic to vancomycin.

If you are able to become pregnant, you may need a pregnancy test before you start using Vibativ. You are considered able to become pregnant unless you have ovarian failure, have had a tubal ligation or hysterectomy, or have been in menopause or not had a menstrual period in 2 years.

FDA pregnancy category C. You may not be able to use Vibativ if you are pregnant. It is not known whether telavancin will harm an unborn baby. In animal studies, telavancin caused birth defects. Use effective birth control to prevent pregnancy during your treatment with Vibativ, and tell your doctor if you become pregnant.

See also: Pregnancy and breastfeeding warnings (in more detail)

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Vibativ on the baby.

It is not known whether telavancin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is Vibativ given?

Vibativ is usually given once every 24 hours for 7 to 21 days. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Vibativ is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Vibativ must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Do not use Vibativ if it has particles in it. Call your pharmacist for new medication.

After mixing, store in the refrigerator and use within 72 hours.

Mixed medicine must be used within 4 hours if you keep it at room temperature.

Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

While using Vibativ, your kidney function may need to be checked often.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Vibativ will not treat a viral infection such as the common cold or the flu.

This medication can cause unusual results with certain medical tests for bleeding or blood clotting disorders, such as "INR" or prothrombin time tests. Tell any doctor who treats you that you are using Vibativ.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Vibativ.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, stop taking this medication and call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Vibativ side effects

Some side effects may occur during the injection. Tell your caregiver right away if you feel itchy or tingly, or have a red rash on your upper body during the injection.

Get emergency medical help if you have any of these signs of an allergic reaction to Vibativ: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats:

  • diarrhea that is watery or bloody; or

  • signs of kidney problems - little or no urinating, swelling in your ankles or feet, weight gain, or urine that looks foamy.

Common Vibativ side effects may include:

  • foamy urine;

  • nausea, vomiting;

  • diarrhea; or

  • soapy or metallic taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Vibativ dosing information

Usual Adult Dose for Skin and Structure Infection:

Complicated infections: 10 mg/kg IV, infused over 60 minutes, once every 24 hours for 7 to 14 days

Therapy duration should be guided by severity and site of infection and by patient's clinical and bacteriological progress.

What other drugs will affect Vibativ?

Vibativ can harm your kidneys. This effect is increased when you also use certain other medicines, including: cidofovir, tenofovir, certain heart or blood pressure medications, or some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Vibativ, especially:

  • a diuretic or "water pill";

  • heart rhythm medicine;

  • a blood thinner - warfarin, Coumadin, Jantoven;

  • certain heart or blood pressure medicine - benazepril, candesartan, captopril, enalapril, irbesartan, lisinopril, losartan, olmesartan, telmisartan, trandolapril, valsartan, and others; or

  • NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with Vibativ, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vibativ only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.