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Vibativ Side Effects

Generic name: telavancin

Medically reviewed by Last updated on Dec 18, 2023.

Note: This document contains side effect information about telavancin. Some dosage forms listed on this page may not apply to the brand name Vibativ.

Applies to telavancin: intravenous powder for solution.


Intravenous route (Powder for Solution)

Patients with preexisting moderate/severe renal impairment (CrCl 50 mL/min or less) who were treated with telavancin for hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia had increased mortality observed versus vancomycin. Use of telavancin in patients with pre-existing moderate/severe renal impairment (CrCl 50 mL/min or less) should be considered only when the anticipated benefit to the patient outweighs the potential risk. Nephrotoxicity: New onset or worsening renal impairment has occurred. Monitor renal function in all patients. Embryofetal toxicity: Telavancin may cause fetal harm. In animal reproduction studies, adverse developmental outcomes were observed in 3 animal species at clinically relevant doses. Verify pregnancy status prior to initiating treatment and advise females of reproductive potential to use effective contraception.

Serious side effects of Vibativ

Along with its needed effects, telavancin (the active ingredient contained in Vibativ) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking telavancin:

Less common

Incidence not known

Other side effects of Vibativ

Some side effects of telavancin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to telavancin: intravenous powder for injection.


Very common (10% or more): All-cause mortality (up to 44%)

Common (1% to 10%): Fungal infection, fatigue, chills

Uncommon (0.1% to 1%): Septic shock, multi-organ failure, tinnitus, asthenia, malaise, non-cardiac chest pain, peripheral edema, pain, pyrexia, infusion site reactions including Red Man syndrome

Rare (less than 0.1%): Deafness[Ref]


Very common (10% or more): Increased serum creatinine to 1.5 times baseline (up to 16%), renal impairment/renal insufficiency/renal failure (up to 10%)

Common (1% to 10%): Acute renal failure, increased blood creatinine

Uncommon (0.1% to 1%): Increased blood urea[Ref]


Uncommon (0.1% to 1%): Anemia, leukopenia, thrombocythemia, thrombocytopenia, increased eosinophil count, increased neutrophil count, increased INR


Common (1% to 10%): QTc prolongation

Uncommon (0.1% to 1%): Angina pectoris, atrial fibrillation, bradycardia, congestive cardiac failure, prolonged electrocardiogram QT corrected interval, palpitations, sinus tachycardia, supraventricular extrasystoles, ventricular extrasystoles, flushing, hypertension, hypotension, phlebitis[Ref]


Very common (10% or more): Nausea (up to 27%), vomiting (up to 14%)

Common (1% to 10%): Diarrhea, constipation

Uncommon (0.1% to 1%): Clostridium colitis, abdominal pain, dry mouth, dyspepsia, flatulence, oral hypoesthesia[Ref]


Uncommon (0.1% to 1%): Hypersensitivity reactions

Postmarketing reports: Anaphylaxis[Ref]

Nervous system

Very common (10% or more): Metallic/soapy taste disturbance (up to 33%), dysgeusia (more than 10%)

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Ageusia, migraine, paraesthesia, parosmia, somnolence, tremor[Ref]


Very common (10% or more): Foamy urine (up to 13%)

Uncommon (0.1% to 1%): Urinary tract infection, dysuria, hematuria, microalbuminuria, oliguria, pollakiuria, abnormal urine odor


Common (1% to 10%): Increased ALT, increased AST

Uncommon (0.1% to 1%): Hepatitis


Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Erythema, face edema, hyperhidrosis, urticaria[Ref]


Common (1% to 10%): Decreased appetite

Uncommon (0.1% to 1%): Hyperglycemia, hyperkalemia, hypoglycemia, hypokalemia, hypomagnesemia[Ref]


Common (1% to 10%): Rigors

Uncommon (0.1% to 1%): Arthralgia, back pain, muscle cramp, myalgia


Uncommon (0.1% to 1%): Eye irritation, blurred vision


Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Agitation, anxiety, confusional state, depression


Uncommon (0.1% to 1%): Dyspnea, hiccups, nasal congestion, pharyngolaryngeal pain


1. Product Information. Vibativ (telavancin). Theravance Inc. 2009.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.