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Vibativ Side Effects

Generic Name: telavancin

Note: This document contains side effect information about telavancin. Some of the dosage forms listed on this page may not apply to the brand name Vibativ.

For the Consumer

Applies to telavancin: intravenous powder for solution

Along with its needed effects, telavancin (the active ingredient contained in Vibativ) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking telavancin:

Less common
  • Blood in the urine
  • change in the frequency of urination or amount of urine
  • difficulty with breathing
  • drowsiness
  • increased thirst
  • loss of appetite
  • nausea or vomiting
  • swelling of the feet or lower legs
  • weakness
Incidence not known
  • Abdominal or stomach tenderness
  • chills or fever
  • cough
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness, especially when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • hives or itching of the skin
  • nausea or vomiting
  • pain, redness, or soreness at the injection site
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash or redness of the face, base of the neck, upper body, back, and arms
  • severe abdominal or stomach cramps and pain
  • tightness in the chest
  • unusual tiredness or weakness
  • watery and severe diarrhea, which may also be bloody

Some side effects of telavancin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bad, unusual or unpleasant (after) taste
  • change in taste
  • diarrhea
  • foamy urine
Less common
  • Decreased appetite
  • dry, red, hot, or irritated skin
  • feeling unusually cold
  • shivering

For Healthcare Professionals

Applies to telavancin: intravenous powder for injection

Other

Very common (10% or more): All-cause mortality (up to 44%)
Common (1% to 10%): Fungal infection, fatigue, chills
Uncommon (0.1% to 1%): Septic shock, multi-organ failure, tinnitus, asthenia, malaise, non-cardiac chest pain, peripheral edema, pain, pyrexia, infusion site reactions including Red Man syndrome
Rare (less than 0.1%): Deafness[Ref]

Renal

Very common (10% or more): Increased serum creatinine to 1.5 times baseline (up to 16%), renal impairment/renal insufficiency/renal failure (up to 10%)
Common (1% to 10%): Acute renal failure, increased blood creatinine
Uncommon (0.1% to 1%): Increased blood urea[Ref]

Hematologic

Uncommon (0.1% to 1%): Anemia, leukopenia, thrombocythemia, thrombocytopenia, increased eosinophil count, increased neutrophil count, increased INR

Cardiovascular

Common (1% to 10%): QTc prolongation
Uncommon (0.1% to 1%): Angina pectoris, atrial fibrillation, bradycardia, congestive cardiac failure, prolonged electrocardiogram QT corrected interval, palpitations, sinus tachycardia, supraventricular extrasystoles, ventricular extrasystoles, flushing, hypertension, hypotension, phlebitis[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 27%), vomiting (up to 14%)
Common (1% to 10%): Diarrhea, constipation
Uncommon (0.1% to 1%): Clostridium colitis, abdominal pain, dry mouth, dyspepsia, flatulence, oral hypoesthesia[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity reactions
Postmarketing reports: Anaphylaxis[Ref]

Nervous system

Very common (10% or more): Metallic/soapy taste disturbance (up to 33%), dysgeusia (more than 10%)
Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Ageusia, migraine, paraesthesia, parosmia, somnolence, tremor[Ref]

Genitourinary

Very common (10% or more): Foamy urine (up to 13%)
Uncommon (0.1% to 1%): Urinary tract infection, dysuria, hematuria, microalbuminuria, oliguria, pollakiuria, abnormal urine odor

Hepatic

Common (1% to 10%): Increased ALT, increased AST
Uncommon (0.1% to 1%): Hepatitis

Dermatologic

Common (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Erythema, face edema, hyperhidrosis, urticaria[Ref]

Metabolic

Common (1% to 10%): Decreased appetite
Uncommon (0.1% to 1%): Hyperglycemia, hyperkalemia, hypoglycemia, hypokalemia, hypomagnesemia[Ref]

Musculoskeletal

Common (1% to 10%): Rigors
Uncommon (0.1% to 1%): Arthralgia, back pain, muscle cramp, myalgia

Ocular

Uncommon (0.1% to 1%): Eye irritation, blurred vision

Psychiatric

Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Agitation, anxiety, confusional state, depression

Respiratory

Uncommon (0.1% to 1%): Dyspnea, hiccups, nasal congestion, pharyngolaryngeal pain

References

1. "Product Information. Vibativ (telavancin)." Theravance Inc, South San Francisco, CA.

Some side effects of Vibativ may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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