Vibativ Side Effects

Generic name: telavancin

Medically reviewed by Drugs.com. Last updated on Sep 17, 2024.

Note: This document provides detailed information about Vibativ Side Effects associated with telavancin. Some dosage forms listed on this page may not apply specifically to the brand name Vibativ.

Applies to telavancin: intravenous powder for solution.

Precautions

It is very important that your doctor check your progress while you are receiving this medicine to make sure that it is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control during treatment and for at least 2 days after your final dose to keep from getting pregnant. You must have a negative pregnancy test before you will be given this medicine. If you think you have become pregnant while using the medicine, tell your doctor right away.

Do not use this medicine if you are also receiving unfractionated heparin sodium injection. Using these medicines together may cause serious unwanted effects.

Check with your doctor right away if you have blood in the urine, a change in the frequency of urination or amount of urine, difficulty with breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, or swelling of the feet or lower legs. These may be symptoms of a serious kidney problem.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you get the injection.

This medicine may cause a rare but serious type of infusion reaction called the "Red-man Syndrome." Tell your doctor right away if you start to have itching, hives, chills or fever, a fast heartbeat, nausea or vomiting, a rash or redness of the face, base of the neck, upper body, back, and arms.

Telavancin injection may cause diarrhea, and in some cases, it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

If you plan to have children, talk with your doctor before using this medicine. Some men using this medicine have become infertile (unable to have children).

Before you have any medical tests, tell the medical doctor in charge that you are using this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of Vibativ

Some side effects of telavancin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Vibativ

Along with its needed effects, telavancin (the active ingredient contained in Vibativ) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking telavancin:

For healthcare professionals

Applies to telavancin: intravenous powder for injection.

Other adverse events

• Very common (10% or more): All-cause mortality (up to 44%)
• Common (1% to 10%): Fungal infection, fatigue, chills
• Uncommon (0.1% to 1%): Septic shock, multi-organ failure, tinnitus, asthenia, malaise, non-cardiac chest pain, peripheral edema, pain, pyrexia, infusion site reactions including Red Man syndrome
• Rare (less than 0.1%): Deafness^[Ref]

Renal

• Very common (10% or more): Increased serum creatinine to 1.5 times baseline (up to 16%), renal impairment/renal insufficiency/renal failure (up to 10%)
• Common (1% to 10%): Acute renal failure, increased blood creatinine
• Uncommon (0.1% to 1%): Increased blood urea^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Anemia, leukopenia, thrombocythemia, thrombocytopenia, increased eosinophil count, increased neutrophil count, increased INR

Cardiovascular

• Common (1% to 10%): QTc prolongation
• Uncommon (0.1% to 1%): Angina pectoris, atrial fibrillation, bradycardia, congestive cardiac failure, prolonged electrocardiogram QT corrected interval, palpitations, sinus tachycardia, supraventricular extrasystoles, ventricular extrasystoles, flushing, hypertension, hypotension, phlebitis^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (up to 27%), vomiting (up to 14%)
• Common (1% to 10%): Diarrhea, constipation
• Uncommon (0.1% to 1%): Clostridium colitis, abdominal pain, dry mouth, dyspepsia, flatulence, oral hypoesthesia^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity reactions
• Postmarketing reports: Anaphylaxis^[Ref]

Nervous system

• Very common (10% or more): Metallic/soapy taste disturbance (up to 33%), dysgeusia (more than 10%)
• Common (1% to 10%): Headache, dizziness
• Uncommon (0.1% to 1%): Ageusia, migraine, paraesthesia, parosmia, somnolence, tremor^[Ref]

Genitourinary

• Very common (10% or more): Foamy urine (up to 13%)
• Uncommon (0.1% to 1%): Urinary tract infection, dysuria, hematuria, microalbuminuria, oliguria, pollakiuria, abnormal urine odor

Hepatic

• Common (1% to 10%): Increased ALT, increased AST
• Uncommon (0.1% to 1%): Hepatitis

Dermatologic

• Common (1% to 10%): Pruritus, rash
• Uncommon (0.1% to 1%): Erythema, face edema, hyperhidrosis, urticaria^[Ref]

Metabolic

• Common (1% to 10%): Decreased appetite
• Uncommon (0.1% to 1%): Hyperglycemia, hyperkalemia, hypoglycemia, hypokalemia, hypomagnesemia^[Ref]

Musculoskeletal

• Common (1% to 10%): Rigors
• Uncommon (0.1% to 1%): Arthralgia, back pain, muscle cramp, myalgia

Ocular

• Uncommon (0.1% to 1%): Eye irritation, blurred vision

Psychiatric

• Common (1% to 10%): Insomnia
• Uncommon (0.1% to 1%): Agitation, anxiety, confusional state, depression

Respiratory

• Uncommon (0.1% to 1%): Dyspnea, hiccups, nasal congestion, pharyngolaryngeal pain

See also:

Further information

Vibativ side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer