Sacubitril / Valsartan Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 10, 2024.

Applies to sacubitril / valsartan: oral tablet.

Important Warnings This medicine can cause some serious health issues

Oral route (Tablet)

Drugs that act directly on the renin-angiotensin system may cause fetal injury or death.

Discontinue use immediately if pregnancy is detected.

Serious side effects

Along with its needed effects, sacubitril/valsartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sacubitril / valsartan:

More common

• abdominal or stomach pain
• blurred vision
• confusion
• difficult breathing
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• irregular heartbeat
• nausea or vomiting
• nervousness
• numbness or tingling in the hands, feet, or lips
• sweating
• unusual tiredness or weakness
• weakness or heaviness of the legs

Less common

• bloody urine
• decreased frequency or amount of urine
• increased thirst
• loss of appetite
• lower back or side pain
• swelling of the face, fingers, or lower legs
• weight gain

Rare

• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Other side effects

Some side effects of sacubitril / valsartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• cough
• dizziness

For Healthcare Professionals

Applies to sacubitril / valsartan: oral pellet, oral tablet.

General

The most common adverse reactions were hypotension, hyperkalemia, cough, dizziness, and renal failure.^[Ref]

Cardiovascular

• Very common (10% or more): Hypotension (18%)
• Common (1% to 10%): Orthostasis^[Ref]

Metabolic

• Very common (10% or more): Potassium greater than 5.5 mEq/L (16%), hyperkalemia (12%)^[Ref]

Renal

• Very common (10% or more): Serum creatinine increased greater than 50% (16%)
• Common (1% to 10%): Renal failure/acute renal failure^[Ref]

Respiratory

• Common (1% to 10%): Cough^[Ref]

Nervous system

• Common (1% to 10%): Dizziness^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Angioedema
• Postmarketing reports: Rash, pruritus^[Ref]

The incidence of angioedema was 2.4% in Black patients.^[Ref]

Hematologic

• Common (1% to 10%): Hemoglobin/hematocrit decreased greater than 20%^[Ref]

Other

• Common (1% to 10%): Falls^[Ref]

Immunologic

• Postmarketing reports: Hypersensitivity, anaphylactic reaction

Frequently asked questions

• Does Entresto improve ejection fraction?
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Further information

Sacubitril/valsartan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer