Skip to Content

Sacubitril / valsartan Side Effects

In Summary

Commonly reported side effects of sacubitril/valsartan include: hyperkalemia, hypotension, and increased serum creatinine. Other side effects include: acute renal failure, and renal failure. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to sacubitril / valsartan: oral tablet

As well as its needed effects, sacubitril / valsartan may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking sacubitril / valsartan, check with your doctor immediately:

More common:
  • Abdominal or stomach pain
  • blurred vision
  • confusion
  • difficult breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • irregular heartbeat
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • sweating
  • unusual tiredness or weakness
  • weakness or heaviness of the legs
Less common:
  • Bloody urine
  • decreased frequency or amount of urine
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • swelling of the face, fingers, or lower legs
  • weight gain
Rare
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Minor Side Effects

Some sacubitril / valsartan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Cough
  • dizziness

For Healthcare Professionals

Applies to sacubitril / valsartan: oral tablet

General

The most common adverse reactions were hypotension, hyperkalemia, cough, dizziness, and renal failure.[Ref]

Cardiovascular

Very common (10% or more): Hypotension (18%)
Common (1% to 10%): Orthostasis[Ref]

Metabolic

Very common (10% or more): Potassium greater than 5.5 mEq/L (16%), hyperkalemia (12%)[Ref]

Renal

Very common (10% or more): Serum creatinine increased greater than 50% (16%)
Common (1% to 10%): Renal failure/acute renal failure[Ref]

Respiratory

Common (1% to 10%): Cough[Ref]

Nervous system

Common (1% to 10%): Dizziness[Ref]

Dermatologic

Uncommon (0.1% to 1%): Angioedema[Ref]

The incidence of angioedema was 2.4% in Black patients.[Ref]

Hematologic

Common (1% to 10%): Hemoglobin/hematocrit decreased greater than 20%[Ref]

Other

Common (1% to 10%): Falls[Ref]

References

1. "Product Information. Entresto (sacubitril-valsartan)." Novartis Pharmaceuticals, East Hanover, NJ.

It is possible that some side effects of sacubitril / valsartan may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide