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Sacubitril / Valsartan Dosage

Medically reviewed by Drugs.com. Last updated on Apr 3, 2023.

Applies to the following strengths: 24 mg-26 mg; 97 mg-103 mg; 49 mg-51 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Congestive Heart Failure

Initial dose: Sacubitril 49 mg-Valsartan 51 mg orally twice a day

Maintenance dose: Sacubitril 97 mg-Valsartan 103 mg orally twice a day

Comments:


Use: To reduce the risk of cardiovascular death and hospitalization in adult patients with chronic heart failure, especially those with left ventricular ejection fraction (LVEF) below normal.

Usual Pediatric Dose for Congestive Heart Failure

1 Year or Older:
Less than 40 kg: 1.6 mg/kg orally twice a day for 2 weeks, then titrate to 2.3 mg/kg orally twice a day for 2 weeks, and then titrate to 3.1 mg/kg orally twice a day

40 to less than 50 kg: Sacubitril 24 mg-Valsartan 26 mg orally twice a day for 2 weeks, then titrate to sacubitril 49 mg-valsartan 51 mg orally twice a day for 2 weeks, and then titrate to sacubitril 72 mg-valsartan 78 mg orally twice a day

50 kg or greater: Sacubitril 49 mg-Valsartan 51 mg orally twice a day for 2 weeks, then titrate to sacubitril 72 mg-valsartan 78 mg orally twice a day for 2 weeks, and then titrate to sacubitril 97 mg-valsartan 103 mg orally twice a day

Comments:


Use: Treatment of symptomatic heart failure with systemic left ventricular systolic dysfunction in pediatric patients 1 year or older.

Renal Dose Adjustments

Adult:
Mild to moderate renal dysfunction: No adjustment recommended
Severe renal dysfunction (estimated GFR less than 30 mL/min/1.73 m2): Start this drug at half the normally recommended initial dose. After initiation, increase the dose per the recommended dose escalation.

Pediatric (1 Year or Older):
Mild to moderate renal dysfunction: No adjustment recommended
Severe renal dysfunction (estimated GFR less than 30 mL/min/1.73 m2):

Liver Dose Adjustments

Adult:
Mild liver dysfunction: No adjustment recommended
Moderate liver dysfunction (Child-Pugh B): Start this drug at half the normally recommended initial dose. After initiation, increase the dose per the recommended dose escalation.
Severe liver dysfunction: Not recommended

Pediatric (1 Year or Older):
Mild liver dysfunction: No adjustment recommended
Moderate liver dysfunction (Child-Pugh B):

Severe liver dysfunction: Not recommended

Precautions

CONTRAINDICATIONS:


US BOXED WARNING:

Safety and efficacy have not been established in patients younger than 1 year.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice: Oral suspension can be substituted at the recommended tablet dosage in patients unable to swallow tablets.

Storage requirements: Oral suspension can be stored for up to 15 days; do not store above 25C (77F) and do not refrigerate.

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

Monitoring:


Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.