Rolapitant Side Effects
Medically reviewed by Drugs.com. Last updated on Sep 27, 2024.
Applies to rolapitant: oral tablet.
Precautions
Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.
Do not take this medicine if you are also using pimozide (Orap®) or thioridazine (Mellaril®). Using these medicines together may cause serious unwanted effects, including heart rhythm problems.
Talk with your doctor before using this medicine if you plan to have children. Some women who use this medicine have become infertile (unable to have children).
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of rolapitant
Along with its needed effects, rolapitant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking rolapitant:
More common side effects
- black, tarry stools
- chills
- cough
- difficult, burning, or painful urination
- fever
- lower back or side pain
- pale skin
- sore throat
- trouble breathing
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
Less common side effects
- bladder pain
- bloody or cloudy urine
- frequent urge to urinate
Other side effects of rolapitant
Some side effects of rolapitant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- decreased appetite
- dizziness
Less common side effects
- acid or sour stomach
- belching
- heartburn
- hiccups
- indigestion
- stomach discomfort, upset, or pain
For healthcare professionals
Applies to rolapitant: intravenous emulsion, oral tablet.
General adverse events
The most commonly reported side effects included decreased appetite, neutropenia, dizziness, and hiccups.[Ref]
Gastrointestinal
- Common (1% to 10%): Abdominal pain, constipation, dyspepsia, stomatitis
- Uncommon (0.1% to 1%): Abdominal distention, diarrhea, nausea, oral fungal infection
- Rare (less than 0.1%): Abdominal discomfort, bowel habit change, dry mouth, gastroesophageal reflux disease, oral candidiasis, retching[Ref]
Nervous system
- Common (1% to 10%): Dizziness, headache
- Uncommon (0.1% to 1%): Disturbance in attention, dysgeusia, somnolence
- Rare (less than 0.1%): Balance disorder, movement disorder, syncope[Ref]
Hematologic
- Common (1% to 10%): Anemia, neutropenia
- Rare (less than 0.1%): Decreased neutrophil count, increased international normalized ratio (INR), leukopenia, thrombocytopenia[Ref]
Metabolic
- Common (1% to 10%): Decreased appetite
- Rare (less than 0.1%): Dehydration, hypomagnesemia[Ref]
Respiratory
- Common (1% to 10%): Hiccups[Ref]
Genitourinary
- Common (1% to 10%): Urinary tract infection[Ref]
Musculoskeletal
- Uncommon (0.1% to 1%): Myalgia
- Rare (less than 0.1%): Arthralgia, back pain, muscular weakness, rhabdomyolysis[Ref]
Other
- Uncommon (0.1% to 1%): Asthenia
- Rare (less than 0.1%): Gait disturbance, hypoacusis, tinnitus[Ref]
Psychiatric
- Uncommon (0.1% to 1%): Insomnia
- Rare (less than 0.1%): Anxiety, bruxism[Ref]
Dermatologic
- Rare (less than 0.1%): Acneiform dermatitis, alopecia, dry skin[Ref]
Hypersensitivity
- Rare (less than 0.1%): Angioedema, hypersensitivity[Ref]
Cardiovascular
- Rare (less than 0.1%): Hypertension, increased heart rate[Ref]
Immunologic
- Rare (less than 0.1%): Candidiasis[Ref]
Ocular
- Rare (less than 0.1%): Blurred vision[Ref]
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References
1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
2. (2015) "Product Information. Varubi (rolapitant)." Tesaro Inc.
More about rolapitant
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- Dosage information
- During pregnancy
- Drug class: NK1 receptor antagonists
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Patient resources
- Rolapitant drug information
- Rolapitant (Intravenous) (Advanced Reading)
- Rolapitant (Oral) (Advanced Reading)
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Further information
Rolapitant side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.