Skip to main content

Prinzide Side Effects

Generic name: hydrochlorothiazide / lisinopril

Medically reviewed by Drugs.com. Last updated on Sep 16, 2024.

Note: This document provides detailed information about Prinzide Side Effects associated with hydrochlorothiazide / lisinopril. Some dosage forms listed on this page may not apply specifically to the brand name Prinzide.

Applies to hydrochlorothiazide / lisinopril: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Discontinue lisinopril/hydrochlorothiazide as soon as possible when pregnancy is detected, as drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Serious side effects of Prinzide

Along with its needed effects, hydrochlorothiazide / lisinopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / lisinopril:

Less common

  • blurred vision
  • body aches or pain
  • chills
  • confusion
  • cough
  • diarrhea
  • difficulty breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • fever
  • headache
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of voice
  • nausea
  • runny or stuffy nose
  • sneezing
  • sore throat
  • sweating
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shiny bump
  • white, yellow or waxy scar-like area

Other side effects of Prinzide

Some side effects of hydrochlorothiazide / lisinopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • belching
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • decreased interest in sexual intercourse
  • feeling of constant movement of self or surroundings
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • muscle cramps
  • rash
  • sensation of spinning
  • sleepiness or unusual drowsiness
  • stomach discomfort, upset, or pain

For healthcare professionals

Applies to hydrochlorothiazide / lisinopril: oral tablet.

General

The most common adverse reactions were dizziness, headache, cough, fatigue, and orthostatic effects.[Ref]

Nervous system

Hydrochlorothiazide:

Lisinopril:

Respiratory

Hydrochlorothiazide:

Lisinopril:

Other

Hydrochlorothiazide:

Lisinopril:

Cardiovascular

Hydrochlorothiazide:

Lisinopril:

Gastrointestinal

Hydrochlorothiazide:

Lisinopril:

Musculoskeletal

Hydrochlorothiazide:

Lisinopril:

Genitourinary

Hydrochlorothiazide:

Lisinopril:

Dermatologic

Hydrochlorothiazide:

Lisinopril:

Ocular

Hydrochlorothiazide:

Lisinopril:

Hematologic

Hydrochlorothiazide:

Lisinopril:

Renal

Hydrochlorothiazide:

Lisinopril:

Psychiatric

Hydrochlorothiazide:

Lisinopril:

Hepatic

Hydrochlorothiazide:

Lisinopril:

Immunologic

Hydrochlorothiazide:

Lisinopril:

Metabolic

Hydrochlorothiazide:

Lisinopril:

Endocrine

Lisinopril:

References

1. (2022) "Product Information. Prinzide (hydrochlorothiazide-lisinopril)." Merck & Co., Inc

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Prinzide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.