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Prestalia Side Effects

Generic Name: amlodipine / perindopril

Note: This page contains side effects data for the generic drug amlodipine / perindopril. It is possible that some of the dosage forms included below may not apply to the brand name Prestalia.

In Summary

Common side effects of Prestalia include: cough. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to amlodipine / perindopril: oral tablet

As well as its needed effects, amlodipine / perindopril may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking amlodipine / perindopril, check with your doctor immediately:

More common:
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss
Incidence not known:
  • Abdominal or stomach pain
  • arm, back, or jaw pain
  • bloody urine
  • blurred vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • decreased frequency or amount of urine
  • difficult breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast or irregular heartbeat
  • increased thirst
  • irregular heartbeat
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • lower back or side pain
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, back or neck
  • sweating
  • unusual tiredness or weakness
  • weakness or heaviness of the legs

Minor Side Effects

Some amlodipine / perindopril side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Cough
  • dizziness
  • headache
Incidence not known:
  • Diarrhea
  • rash

For Healthcare Professionals

Applies to amlodipine / perindopril: oral tablet

General

The most common side effects were edema, cough, headache, and dizziness.[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Amlodipine:
Common (1% to 10%): Headache, dizziness, somnolence
Uncommon (0.1% to 1%): Syncope, hypoesthesia, neuropathy peripheral, paraesthesia, tremor, dysgeusia, postural dizziness
Rare (0.01% to 0.1%): Amnesia, migraine
Very rare (less than 0.01%): Hypertonia
Frequency not reported: Extrapyramidal syndrome

Perindopril:
Common (1% to 10%): Headache, dizziness, drowsiness, paraesthesia, dysgeusia
Very rare (less than 0.01%): Stroke[Ref]

Other

Common (1% to 10%): Edema peripheral, vertigo, fatigue, lethargy

Amlodipine:
Very common (10% or more): Edema peripheral (13.2%)
Common (1% to 10%): Edema, fatigue
Uncommon (0.1% to 1%): Vertigo, asthenia, malaise, pain, tinnitus, gynecomastia
Rare (less than 0.1%): Ataxia

Perindopril:
Common (1% to 10%): Vertigo, tinnitus, asthenia
Uncommon (0.1% to 1%): Edema peripheral, atypical chest pain
Postmarketing reports: Falls, serositis, fever[Ref]

Respiratory

Common (1% to 10%): Cough, dyspnea

Amlodipine:
Uncommon (0.1% to 1%): Cough, dyspnea, epistaxis, rhinitis
Rare (less than 0.1%): Parosmia

Perindopril:
Very common (10% or more): Cough (up to 12%)
Common (1% to 10%): Dyspnea, epistaxis
Uncommon (0.1% to 1%): Bronchospasm
Very rare (less than 0.01%): Rhinitis, eosinophilic pneumonia[Ref]

Cardiovascular

Common (1% to 10%): Chest pain
Uncommon (0.1% to 1%): Bradycardia, peripheral coldness

Amlodipine:
Common (1% to 10%): Palpitations, flushing
Uncommon (0.1% to 1%): Arrhythmia, bradycardia, chest pain, peripheral ischemia, tachycardia, vasculitis, hot flushes, postural hypotension, hypotension, vasculitis
Rare (0.01% to 0.1%): Myocardial infarction, angina pain, cardiac failure, pulse irregularity, extrasystoles, cold and clammy skin

Perindopril:
Common (1% to 10%): Palpitations, impaired peripheral circulation, flushing, hypotension, discomfort on exertion
Very rare (less than 0.01%): Angina pectoris, myocardial infarction, arrhythmia, vasculitis
Postmarketing reports: Cardiac arrest[Ref]

Dermatologic

Common (1% to 10%): Eczema
Frequency not reported: Rash

Amlodipine:
Uncommon (0.1% to 1%): Erythema multiforme, pruritus, rash, rash erythematosus, rash maculopapular, sweating increased, purpura, alopecia, hyperhidrosis, exanthema, skin discoloration
Rare (0.01% to 0.1%): Skin dryness, dermatitis, urticaria
Very rare (less than 0.01%): Stevens-Johnson syndrome, exfoliative dermatitis, photosensitivity

Perindopril:
Common (1% to 10%): Pruritus, rash, exanthema
Uncommon (0.1% to 1%): Hyperhidrosis, urticaria
Very rare (less than 0.01%): Erythema multiforme
Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea
Frequency not reported: Nausea

Amlodipine:
Common (1% to 10%): Abdominal pain, nausea
Uncommon (0.1% to 1%): Constipation, dysphagia, diarrhea, flatulence, vomiting, gingival hyperplasia, dry mouth, dyspepsia, altered bowel habits
Rare (less than 0.1%): Loose stools, gastritis

Perindopril:
Common (1% to 10%): Abdominal pain, nausea, vomiting, dyspepsia, diarrhea, constipation
Uncommon (0.1% to 1%): Dry mouth[Ref]

Genitourinary

Common (1% to 10%): Erectile dysfunction

Amlodipine:
Uncommon (0.1% to 1%): Sexual dysfunction, micturition frequency, micturition disorder, nocturia, impotence
Rare (less than 0.1%): Dysuria

Perindopril:
Uncommon (0.1% to 1%): Impotence[Ref]

Hematologic

Amlodipine:
Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia
Very rare (less than 0.01%): Neutropenia

Perindopril:
Uncommon (0.1% to 1%): Leukopenia
Very rare (less than 0.01%): Agranulocytosis or pancytopenia, thrombocytopenia, hemolytic anemia in patients with a congenital glucose-6-phosphate dehydrogenase deficiency, decrease in hemoglobin and hematocrit
Postmarketing reports: Anemia, leucocytosis, eosinophilia, elevated erythrocyte sedimentation rate[Ref]

Hepatic

Amlodipine:
Uncommon (0.1% to 1%): Pancreatitis
Rare (less than 0.1%): Hepatitis, jaundice, hepatic enzyme elevations

Perindopril:
Common (1% to 10%): ALT elevated
Uncommon (0.1% to 1%): AST elevated
Rare (0.01% to 0.1%): Serum bilirubin elevated
Very rare (less than 0.01%): Pancreatitis, hepatitis
Postmarketing reports: Hepatic failure, jaundice[Ref]

Immunologic

Amlodipine:
Uncommon (0.1% to 1%): Allergic reaction, angioedema
Very rare (less than 0.01%): Quincke's edema

Perindopril:
Uncommon (0.1% to 1%): Allergic reactions, angioedema
Postmarketing reports: Positive antinuclear antibody[Ref]

Metabolic

Common (1% to 10%): Hyperkalemia

Amlodipine:
Uncommon (0.1% to 1%): Anorexia, weight gain, weight decrease, hyperglycemia, thirst
Rare (less than 0.1%): Increased appetite

Perindopril:
Frequency not reported: Hypoglycemia, hyperkalemia
Postmarketing reports: Symptomatic hyponatremia[Ref]

Musculoskeletal

Frequency not reported: Joint swelling

Amlodipine:
Common (1% to 10%): Ankle swelling
Uncommon (0.1% to 1%): Back pain, rigors, arthralgia, arthrosis, muscle cramps, myalgia
Rare (less than 0.1%): Muscle weakness, twitching

Perindopril:
Common (1% to 10%): Back pain, muscle cramps
Postmarketing reports: Arthralgia/arthritis, myalgia[Ref]

Ocular

Amlodipine:
Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain, visual disturbances
Rare (less than 0.1%): Dry eyes, abnormal visual accommodation

Perindopril:
Common (1% to 10%): Visual disturbances[Ref]

Psychiatric

Amlodipine:
Uncommon (0.1% to 1%): Insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization, mood changes
Rare (less than 0.1%): Apathy, agitation, confusion

Perindopril:
Uncommon (0.1% to 1%): Mood changes, sleep disturbances
Very rare (less than 0.01%): Depression, confusion, hallucinations[Ref]

Renal

Perindopril:
Uncommon (0.1% to 1%): Renal impairment
Very rare (less than 0.01%): Acute renal failure
Frequency not reported: Blood urea increased, serum creatinine increased
Postmarketing reports: Nephritis[Ref]

References

1. "Product Information. Prestalia (amLODIPine-perindopril)." Symplmed, Cincinnati, OH.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of Prestalia may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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