Prestalia Side Effects

Generic name: amlodipine / perindopril

Medically reviewed by Drugs.com. Last updated on Jan 11, 2025.

Note: This document provides detailed information about Prestalia Side Effects associated with amlodipine / perindopril. Some dosage forms listed on this page may not apply specifically to the brand name Prestalia.

Applies to amlodipine / perindopril: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

You should not use this medicine together with sacubitril. Do not use this medicine and sacubitril/valsartan (Entresto®) within 36 hours of each other.

This medicine may cause serious allergic reactions, including anaphylaxis. This can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, lips, tongue, or throat while you are using this medicine.

Check with your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.

This medicine may cause angina (chest pain) or a heart attack in certain patients with severe heart or blood vessel disease. Check with your doctor right away if you are having chest pain or discomfort, fast or irregular heartbeat, nausea or vomiting, pain or discomfort in the arms, jaw, back, or neck, shortness of breath, or sweating.

Dizziness, lightheadedness, or fainting, may occur especially when you get up suddenly from a lying or sitting position or if you have been taking a diuretic (water pill). Do not drive or do anything else that could be dangerous if you are dizzy. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.

Check with your doctor right away if you have bloody urine, decrease in frequency or amount of urine, increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Before having any type of surgery (including dental surgery) or emergency treatment, tell the doctor or dentist in charge that you are taking this medicine.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea, vomiting, nervousness, numbness or tingling in the hands, feet, or lips, shortness of breath, or weakness or heaviness of the legs. Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

This medicine may be less effective in black patients. Black patients also have an increased risk of swelling of the hands, arms, face, mouth, or throat. Talk with your doctor if you have concerns about this.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

Serious side effects of Prestalia

Along with its needed effects, amlodipine / perindopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / perindopril:

Other side effects of Prestalia

Some side effects of amlodipine / perindopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to amlodipine / perindopril: oral tablet.

General adverse events

The most common side effects were edema, cough, headache, and dizziness.^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness

Amlodipine:

• Common (1% to 10%): Headache, dizziness, somnolence
• Uncommon (0.1% to 1%): Syncope, hypoesthesia, neuropathy peripheral, paraesthesia, tremor, dysgeusia, postural dizziness
• Rare (0.01% to 0.1%): Amnesia, migraine
• Very rare (less than 0.01%): Hypertonia
• Frequency not reported: Extrapyramidal syndrome

Perindopril:

• Common (1% to 10%): Headache, dizziness, drowsiness, paraesthesia, dysgeusia
• Very rare (less than 0.01%): Stroke^[Ref]

Other

• Common (1% to 10%): Edema peripheral, vertigo, fatigue, lethargy

Amlodipine:

• Very common (10% or more): Edema peripheral (13.2%)
• Common (1% to 10%): Edema, fatigue
• Uncommon (0.1% to 1%): Vertigo, asthenia, malaise, pain, tinnitus, gynecomastia
• Rare (less than 0.1%): Ataxia

Perindopril:

• Common (1% to 10%): Vertigo, tinnitus, asthenia
• Uncommon (0.1% to 1%): Edema peripheral, atypical chest pain
• Postmarketing reports: Falls, serositis, fever^[Ref]

Respiratory

• Common (1% to 10%): Cough, dyspnea

Amlodipine:

• Uncommon (0.1% to 1%): Cough, dyspnea, epistaxis, rhinitis
• Rare (less than 0.1%): Parosmia

Perindopril:

• Very common (10% or more): Cough (up to 12%)
• Common (1% to 10%): Dyspnea, epistaxis
• Uncommon (0.1% to 1%): Bronchospasm
• Very rare (less than 0.01%): Rhinitis, eosinophilic pneumonia^[Ref]

Cardiovascular

• Common (1% to 10%): Chest pain
• Uncommon (0.1% to 1%): Bradycardia, peripheral coldness

Amlodipine:

• Common (1% to 10%): Palpitations, flushing
• Uncommon (0.1% to 1%): Arrhythmia, bradycardia, chest pain, peripheral ischemia, tachycardia, vasculitis, hot flushes, postural hypotension, hypotension, vasculitis
• Rare (0.01% to 0.1%): Myocardial infarction, angina pain, cardiac failure, pulse irregularity, extrasystoles, cold and clammy skin

Perindopril:

• Common (1% to 10%): Palpitations, impaired peripheral circulation, flushing, hypotension, discomfort on exertion
• Very rare (less than 0.01%): Angina pectoris, myocardial infarction, arrhythmia, vasculitis
• Postmarketing reports: Cardiac arrest^[Ref]

Dermatologic

• Common (1% to 10%): Eczema
• Frequency not reported: Rash

Amlodipine:

• Uncommon (0.1% to 1%): Erythema multiforme, pruritus, rash, rash erythematosus, rash maculopapular, sweating increased, purpura, alopecia, hyperhidrosis, exanthema, skin discoloration
• Rare (0.01% to 0.1%): Skin dryness, dermatitis, urticaria
• Very rare (less than 0.01%): Stevens-Johnson syndrome, exfoliative dermatitis, photosensitivity

Perindopril:

• Common (1% to 10%): Pruritus, rash, exanthema
• Uncommon (0.1% to 1%): Hyperhidrosis, urticaria
• Very rare (less than 0.01%): Erythema multiforme
• Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea
• Frequency not reported: Nausea

Amlodipine:

• Common (1% to 10%): Abdominal pain, nausea
• Uncommon (0.1% to 1%): Constipation, dysphagia, diarrhea, flatulence, vomiting, gingival hyperplasia, dry mouth, dyspepsia, altered bowel habits
• Rare (less than 0.1%): Loose stools, gastritis

Perindopril:

• Common (1% to 10%): Abdominal pain, nausea, vomiting, dyspepsia, diarrhea, constipation
• Uncommon (0.1% to 1%): Dry mouth^[Ref]

Genitourinary

• Common (1% to 10%): Erectile dysfunction

Amlodipine:

• Uncommon (0.1% to 1%): Sexual dysfunction, micturition frequency, micturition disorder, nocturia, impotence
• Rare (less than 0.1%): Dysuria

Perindopril:

• Uncommon (0.1% to 1%): Impotence^[Ref]

Hematologic

Amlodipine:

• Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia
• Very rare (less than 0.01%): Neutropenia

Perindopril:

• Uncommon (0.1% to 1%): Leukopenia
• Very rare (less than 0.01%): Agranulocytosis or pancytopenia, thrombocytopenia, hemolytic anemia in patients with a congenital glucose-6-phosphate dehydrogenase deficiency, decrease in hemoglobin and hematocrit
• Postmarketing reports: Anemia, leucocytosis, eosinophilia, elevated erythrocyte sedimentation rate^[Ref]

Hepatic

Amlodipine:

• Uncommon (0.1% to 1%): Pancreatitis
• Rare (less than 0.1%): Hepatitis, jaundice, hepatic enzyme elevations

Perindopril:

• Common (1% to 10%): ALT elevated
• Uncommon (0.1% to 1%): AST elevated
• Rare (0.01% to 0.1%): Serum bilirubin elevated
• Very rare (less than 0.01%): Pancreatitis, hepatitis
• Postmarketing reports: Hepatic failure, jaundice^[Ref]

Immunologic

Amlodipine:

• Uncommon (0.1% to 1%): Allergic reaction, angioedema
• Very rare (less than 0.01%): Quincke's edema

Perindopril:

• Uncommon (0.1% to 1%): Allergic reactions, angioedema
• Postmarketing reports: Positive antinuclear antibody^[Ref]

Metabolic

• Common (1% to 10%): Hyperkalemia

Amlodipine:

• Uncommon (0.1% to 1%): Anorexia, weight gain, weight decrease, hyperglycemia, thirst
• Rare (less than 0.1%): Increased appetite

Perindopril:

• Frequency not reported: Hypoglycemia, hyperkalemia
• Postmarketing reports: Symptomatic hyponatremia^[Ref]

Musculoskeletal

• Frequency not reported: Joint swelling

Amlodipine:

• Common (1% to 10%): Ankle swelling
• Uncommon (0.1% to 1%): Back pain, rigors, arthralgia, arthrosis, muscle cramps, myalgia
• Rare (less than 0.1%): Muscle weakness, twitching

Perindopril:

• Common (1% to 10%): Back pain, muscle cramps
• Postmarketing reports: Arthralgia/arthritis, myalgia^[Ref]

Ocular

Amlodipine:

• Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain, visual disturbances
• Rare (less than 0.1%): Dry eyes, abnormal visual accommodation

Perindopril:

• Common (1% to 10%): Visual disturbances^[Ref]

Psychiatric

Amlodipine:

• Uncommon (0.1% to 1%): Insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization, mood changes
• Rare (less than 0.1%): Apathy, agitation, confusion

Perindopril:

• Uncommon (0.1% to 1%): Mood changes, sleep disturbances
• Very rare (less than 0.01%): Depression, confusion, hallucinations^[Ref]

Renal

Perindopril:

• Uncommon (0.1% to 1%): Renal impairment
• Very rare (less than 0.01%): Acute renal failure
• Frequency not reported: Blood urea increased, serum creatinine increased
• Postmarketing reports: Nephritis^[Ref]

See also:

Further information

Prestalia side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer