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Prestalia Side Effects

Generic name: amlodipine / perindopril

Medically reviewed by Last updated on Dec 6, 2023.

Note: This document contains side effect information about amlodipine / perindopril. Some dosage forms listed on this page may not apply to the brand name Prestalia.

Applies to amlodipine / perindopril: oral tablet.


Oral route (Tablet)

Discontinue as soon as pregnancy is detected. Injury and death of the developing fetus may occur with the use of drugs that act directly on the renin-angiotensin system.

Serious side effects of Prestalia

Along with its needed effects, amlodipine/perindopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / perindopril:

More common

Incidence not known

Other side effects of Prestalia

Some side effects of amlodipine / perindopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to amlodipine / perindopril: oral tablet.


The most common side effects were edema, cough, headache, and dizziness.[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness


Common (1% to 10%): Headache, dizziness, somnolence

Uncommon (0.1% to 1%): Syncope, hypoesthesia, neuropathy peripheral, paraesthesia, tremor, dysgeusia, postural dizziness

Rare (0.01% to 0.1%): Amnesia, migraine

Very rare (less than 0.01%): Hypertonia

Frequency not reported: Extrapyramidal syndrome


Common (1% to 10%): Headache, dizziness, drowsiness, paraesthesia, dysgeusia

Very rare (less than 0.01%): Stroke[Ref]


Common (1% to 10%): Edema peripheral, vertigo, fatigue, lethargy


Very common (10% or more): Edema peripheral (13.2%)

Common (1% to 10%): Edema, fatigue

Uncommon (0.1% to 1%): Vertigo, asthenia, malaise, pain, tinnitus, gynecomastia

Rare (less than 0.1%): Ataxia


Common (1% to 10%): Vertigo, tinnitus, asthenia

Uncommon (0.1% to 1%): Edema peripheral, atypical chest pain

Postmarketing reports: Falls, serositis, fever[Ref]


Common (1% to 10%): Cough, dyspnea


Uncommon (0.1% to 1%): Cough, dyspnea, epistaxis, rhinitis

Rare (less than 0.1%): Parosmia


Very common (10% or more): Cough (up to 12%)

Common (1% to 10%): Dyspnea, epistaxis

Uncommon (0.1% to 1%): Bronchospasm

Very rare (less than 0.01%): Rhinitis, eosinophilic pneumonia[Ref]


Common (1% to 10%): Chest pain

Uncommon (0.1% to 1%): Bradycardia, peripheral coldness


Common (1% to 10%): Palpitations, flushing

Uncommon (0.1% to 1%): Arrhythmia, bradycardia, chest pain, peripheral ischemia, tachycardia, vasculitis, hot flushes, postural hypotension, hypotension, vasculitis

Rare (0.01% to 0.1%): Myocardial infarction, angina pain, cardiac failure, pulse irregularity, extrasystoles, cold and clammy skin


Common (1% to 10%): Palpitations, impaired peripheral circulation, flushing, hypotension, discomfort on exertion

Very rare (less than 0.01%): Angina pectoris, myocardial infarction, arrhythmia, vasculitis

Postmarketing reports: Cardiac arrest[Ref]


Common (1% to 10%): Eczema

Frequency not reported: Rash


Uncommon (0.1% to 1%): Erythema multiforme, pruritus, rash, rash erythematosus, rash maculopapular, sweating increased, purpura, alopecia, hyperhidrosis, exanthema, skin discoloration

Rare (0.01% to 0.1%): Skin dryness, dermatitis, urticaria

Very rare (less than 0.01%): Stevens-Johnson syndrome, exfoliative dermatitis, photosensitivity


Common (1% to 10%): Pruritus, rash, exanthema

Uncommon (0.1% to 1%): Hyperhidrosis, urticaria

Very rare (less than 0.01%): Erythema multiforme

Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis[Ref]


Common (1% to 10%): Diarrhea

Frequency not reported: Nausea


Common (1% to 10%): Abdominal pain, nausea

Uncommon (0.1% to 1%): Constipation, dysphagia, diarrhea, flatulence, vomiting, gingival hyperplasia, dry mouth, dyspepsia, altered bowel habits

Rare (less than 0.1%): Loose stools, gastritis


Common (1% to 10%): Abdominal pain, nausea, vomiting, dyspepsia, diarrhea, constipation

Uncommon (0.1% to 1%): Dry mouth[Ref]


Common (1% to 10%): Erectile dysfunction


Uncommon (0.1% to 1%): Sexual dysfunction, micturition frequency, micturition disorder, nocturia, impotence

Rare (less than 0.1%): Dysuria


Uncommon (0.1% to 1%): Impotence[Ref]



Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia

Very rare (less than 0.01%): Neutropenia


Uncommon (0.1% to 1%): Leukopenia

Very rare (less than 0.01%): Agranulocytosis or pancytopenia, thrombocytopenia, hemolytic anemia in patients with a congenital glucose-6-phosphate dehydrogenase deficiency, decrease in hemoglobin and hematocrit

Postmarketing reports: Anemia, leucocytosis, eosinophilia, elevated erythrocyte sedimentation rate[Ref]



Uncommon (0.1% to 1%): Pancreatitis

Rare (less than 0.1%): Hepatitis, jaundice, hepatic enzyme elevations


Common (1% to 10%): ALT elevated

Uncommon (0.1% to 1%): AST elevated

Rare (0.01% to 0.1%): Serum bilirubin elevated

Very rare (less than 0.01%): Pancreatitis, hepatitis

Postmarketing reports: Hepatic failure, jaundice[Ref]



Uncommon (0.1% to 1%): Allergic reaction, angioedema

Very rare (less than 0.01%): Quincke's edema


Uncommon (0.1% to 1%): Allergic reactions, angioedema

Postmarketing reports: Positive antinuclear antibody[Ref]


Common (1% to 10%): Hyperkalemia


Uncommon (0.1% to 1%): Anorexia, weight gain, weight decrease, hyperglycemia, thirst

Rare (less than 0.1%): Increased appetite


Frequency not reported: Hypoglycemia, hyperkalemia

Postmarketing reports: Symptomatic hyponatremia[Ref]


Frequency not reported: Joint swelling


Common (1% to 10%): Ankle swelling

Uncommon (0.1% to 1%): Back pain, rigors, arthralgia, arthrosis, muscle cramps, myalgia

Rare (less than 0.1%): Muscle weakness, twitching


Common (1% to 10%): Back pain, muscle cramps

Postmarketing reports: Arthralgia/arthritis, myalgia[Ref]



Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain, visual disturbances

Rare (less than 0.1%): Dry eyes, abnormal visual accommodation


Common (1% to 10%): Visual disturbances[Ref]



Uncommon (0.1% to 1%): Insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization, mood changes

Rare (less than 0.1%): Apathy, agitation, confusion


Uncommon (0.1% to 1%): Mood changes, sleep disturbances

Very rare (less than 0.01%): Depression, confusion, hallucinations[Ref]



Uncommon (0.1% to 1%): Renal impairment

Very rare (less than 0.01%): Acute renal failure

Frequency not reported: Blood urea increased, serum creatinine increased

Postmarketing reports: Nephritis[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. Cerner Multum, Inc. "Australian Product Information."

3. (2015) "Product Information. Prestalia (amlodipine-perindopril)." Symplmed

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.