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Potiga Side Effects

Generic name: ezogabine

Medically reviewed by Last updated on Oct 24, 2023.

Note: This document contains side effect information about ezogabine. Some dosage forms listed on this page may not apply to the brand name Potiga.

Applies to ezogabine: oral tablet.


  • This drug can cause certain eye problems. These eye problems may lead to lasting loss of eyesight. This drug is only for use if other drugs have not worked. Eye exams will be done before starting this drug and during treatment to watch for these eye problems. Call your doctor right away if you have any change in eyesight. Talk with your doctor to be sure that the benefits of this drug are more than the risks.

Serious side effects of Potiga

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of Potiga

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to ezogabine: oral tablet.


Very common (10% or more): Retinal pigmentary abnormalities (up to 30%)

Common (1% to 10%): Diplopia, blurred vision

Frequency not reported: Decreased visual acuity, nystagmus

Postmarketing reports: Acquired vitelliform lesions[Ref]


Very common (10% or more): Discoloration of the skin, palate, scleral, nail, conjunctiva, lip, and/or mucous membrane (up to 40%)

Uncommon (0.1% to 1%): Hyperhidrosis, skin rash

Frequency not reported: Alopecia[Ref]


Common (1% to 10%): Confusional state, psychotic disorders, hallucinations, anxiety, disorientation

Frequency not reported: Euphoric mood[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 23%), somnolence (up to 22%)

Common (1% to 10%): Memory impairment, tremor, vertigo, abnormal coordination, disturbance in attention, gait disturbance, aphasia, dysarthria, balance disorder, paresthesia, amnesia, myoclonus

Frequency not reported: Syncope, coma, encephalopathy[Ref]


Common (1% to 10%): Urinary retention, urinary hesitation, dysuria, hematuria, chromaturia[Ref]


Common (1% to 10%): Nausea, constipation, dyspepsia, dry mouth

Uncommon (0.1% to 1%): Dysphasia[Ref]


Frequency not reported: Leukopenia, neutropenia, thrombocytopenia[Ref]


Common (1% to 10%): Increased liver enzymes (less than 2%)

Frequency not reported: Nephrolithiasis[Ref]


Common (1% to 10%): Influenza[Ref]


Common (1% to 10%): Increased weight, increased appetite[Ref]


Uncommon (0.1% to 1%): Hypokinesia

Frequency not reported: Muscle spasms[Ref]


Very common (10% or more): Fatigue (up to 15%)

Common (1% to 10%): Asthenia, malaise, peripheral edema[Ref]


Uncommon (0.1% to 1%): Nephrolithiasis

Frequency not reported: Renal colic[Ref]


Frequency not reported: Dyspnea[Ref]


1. (2011) "Product Information. Potiga (ezogabine)." GlaxoSmithKline

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.