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Pirbuterol Side Effects

Applies to pirbuterol: inhalation aerosol

Cardiovascular

Cardiovascular side effects have included palpitations and peripheral vasodilation, commonly resulting in reflex tachycardia. Blood pressure may increase or decrease. Higher doses may rarely aggravate angina, myocardial ischemia, or cause atrial or ventricular arrhythmias.[Ref]

Although most studies have not revealed a significant effect of pirbuterol on blood pressure or heart rate, anecdotally significant increases have been noted. Aggravation of angina may be due to tachycardia produced by pirbuterol. Supraventricular premature beats and ventricular tachycardia have also been reported. Higher doses of pirbuterol should be used with caution in patients with cardiac disease, arrhythmias, or hypertension. All of these effects are dose-related and lower doses may be tolerated.[Ref]

Musculoskeletal

Musculoskeletal side effects have included tremors, especially at higher doses.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, dry mouth, and diarrhea.[Ref]

Metabolic

Metabolic side effects have included hypokalemia and, less commonly, hyperglycemia.[Ref]

Nervous system

Nervous system side effects have included nervousness, dizziness, insomnia, and headache.[Ref]

Respiratory

Respiratory side effects have included cough. Rare instances of paradoxical bronchoconstriction have been associated with the use of pirbuterol.[Ref]

References

1. "Product Information. Maxair (pirbuterol)." 3M Pharmaceuticals, St. Paul, MN.

2. Richards DM, Brogden RN "Pirbuterol. A preliminary review of its pharmacological properties and therapeutic efficacy in reversible bronchospastic disease." Drugs 30 (1985): 6-21

3. Chodosh S, Crooks LA, Tuck J "Comparative effects of pirbuterol acetate, metaproterenol, and placebo aerosols on pulmonary function and incidence of cardiac ectopy." J Asthma 26 (1989): 309-15

4. Beumer HM "Long-term treatment of bronchial asthma with pirbuterol aerosol." Int J Clin Pharmacol Ther Toxicol 21 (1983): 172-5

5. Littner MR, Tashkin DP, Calvarese B, Bautista M "Acute bronchial and cardiovascular effects of increasing doses of pirbuterol acetate aerosol in asthma." Ann Allergy 48 (1982): 14-20

6. Beumer HM "Pirbuterol versus orciprenaline aerosols in the treatment of bronchial asthma." Int J Clin Pharmacol Ther Toxicol 21 (1983): 147-66

7. Tinkelman DG, Brandon ML, Grieco M, Hudson L, Rosenthal RR, Spector SL, Tashkin D, Votteri B "Comparison of safety and efficacy of inhaled pirbuterol with metaproterenol." Ann Allergy 64 (1990): 202-6

8. Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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